Novel Use Of Cap-assisted Enteroscopy For Detection Of Colorectal Tumor In A Patient With Incarcerated Inguinal Hernia

Multiple reports have documented unsuspected inguinal hernias which result in difficulties during the colonoscopic examinations of patients. In most cases, the colonoscopy can be delayed until a surgical consult has further evaluated the inguinal hernia. This case report documents a patient who required a colonoscopy but surgical intervention for the detected inguinal hernia was not appropriate due to his co-morbid medical conditions. With the use of the combination of an enteroscope fitted with a cap and fluoroscopy, the inguinal hernia was able to be negotiated and the diagnosis of a cecal carcinoma was able to be confirmed.published_or_final_versio

Neural systems for auditory perception of lexical tones

Previous neuroimaging research on cognitive processing of speech tone has generated dramatically different patterns of findings. Even at the basic perception level, brain mapping studies of lexical tones have yielded inconsistent results. Apart from the data inconsistency problem, experimental materials in past studies of tone perception carried little or minimal lexical semantics, an important dimension that should not be dispensed with because speech tones serve to distinguish lexical meanings. The present study sought to examine the neural correlates of the perception of speech tone using lexically meaningful experimental stimuli. A simple lexical tone perception task was devised in which native Mandarin speakers were asked to judge whether or not the two syllables of an auditorily presented Chinese bisyllabic word had the same tone. We selected bisyllabic words as experimental stimuli because Chinese monosyllables often convey little or very vague meanings due to rampant homophony. We found that the left inferior frontal gyrus, the right middle temporal gyrus and bilateral superior temporal gyri are responsible for basic perception of linguistic pitches. Our interpretation of the data sees the left superior temporal gyrus as engaged in primary acoustic analysis of the auditory stimuli, while the right middle superior temporal gyrus and the left inferior frontal region are involved in both tonal and semantic processing of the language stimuli.postprin

Chemoprophylaxis in colorectal cancer: Current concepts and a practical algorithm for use

Colorectal cancer (CRC) is the second most common lethal cancer in the Western world. There is a 10 to 20 years lead time from normal mucosa to carcinoma which offers a window of opportunity to modify and prevent the outcome of CRC, with its incipient morbidity and mortality. The objective of this paper is to review the evidence for chemoprophylaxis in CRC, identify currently used agents and determine their role in the current management algorithm of CRC. Large cohort-control and randomised controlled trials in the most studied chemoprophylaxis agents are reviewed. Currently, the role for chemoprophylaxis in CRC remains a niche area, with celecoxib the only recommended agent for use in patients with familial polyposis syndromes. However, the role of chemoprophylaxis is likely to grow significantly in the next decade as understanding of the stepwise tumorigenesis cascade becomes better understood and current clinical trials are completed. © 2010 Informa UK Ltd.postprin

Krit1 inhibited proliferation and metastasis of human colon cancer via DPPIV signaling pathway

Oral presentationpublished_or_final_versionThe 15th Annual Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16, suppl. 1, p. 67, abstract no. 11

Promoter hypermethylation and histone hypoacetylation contribute to pancreatic-duodenal homeobox 1 silencing in gastric cancer

Background and Aims: The expression of pancreatic-duodenal homeobox 1 (PDX1) in gastric cancer is aberrantly reduced. The aim of this study was to elucidate the regulation of DNA methylation and histone acetylation at the promoter for PDX1 silencing in gastric cancer. Methods: PDX1 expression in response to demethylation and acetylation was detected in human gastric cancer cell lines by reverse transcription-polymerase chain reaction (PCR) and western blot. Four CpG islands within the 5#-flanking region of PDX1 gene were analyzed with their transcription activities being detected by dual luciferase assay. Promoter hypermethylation was identified in gastric cancer cell lines and cancer tissues by methylation-specific PCR or bisulfite DNA sequencing PCR analysis. Histone acetylation was determined by chromatin immunoprecipitation (ChIP) assay. Results: Demethylation by 5′-aza-2′-deoxycytidine (5′-aza-dC) and/or acetylation by trichostatin A (TSA) restored PDX1 expression in gastric cancer cells. Hypermethylation was found in four CpG islands in six of seven cancer cell lines. However, only the distal CpG island located in the promoter fragment of PDX1, F383 (c.22063 to 21681 nt upstream of the ATG start codon) displayed significant transcriptional activity that could be suppressed by SssI methylase and increased by 5′-aza-dC and TSA. More than 70% of the single CpG sites in F383 were methylated with hypermethylation of F383 fragment more common in gastric cancerous tissues compared with the paired normal tissues (P < 0.05). ChIP assay showed F383 was also associated with low hypoacetylation level of the histones. Conclusion: Promoter hypermethylation and histone hypoacetylation contribute to PDX1 silencing in gastric cancer. © The Author 2010. Published by Oxford University Press. All rights reserved.postprin

A false sense of security; Symptom control does not predict healing of oesophagitis on proton pump inhibitors

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Patients vote with their feet for 'On demand' rabeprazole in the maintenance treatment phase of reflux oesophagitis

Comment in Aliment Pharmacol Ther. 2010 May;31(9):950-960.link_to_OA_fulltex

Management of gastric cancer in the Asia-Pacific region: necessity drives differences

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One size does not fit all - Time to regionalize Helicobacter pylori eradication?: Letters to the Editors

Comment in Aliment Pharmacol Ther. 2010 May;31(10):1077-1084.link_to_OA_fulltex