400 research outputs found
The ISCIP Analyst, Volume VI, Issue 15
This repository item contains a single issue of The ISCIP Analyst, an analytical review journal published from 1996 to 2010 by the Boston University Institute for the Study of Conflict, Ideology, and Policy
Decreasing Pain in Pediatric Patients During Intravenous Catheter Insertions on the Pediatric Inpatient Surgery Unit
Abstract
As healthcare in the United States transforms, the voice of advocacy for pediatric patients is also evolving. The act of inserting a peripheral intravenous (IV) catheter for medical care of a pediatric patient is one of the most common invasive procedures in the healthcare industry. However, the preventable pain accompanying such a common procedure is often overlooked. Pediatric patients are different than adults due to the lack of physiological and psychological development. When a peripheral intravenous catheter is inserted without pain prevention interventions, there are long-term and short-term consequences for the patient and family. In turn, there are many benefits attributed to utilizing pain prevention interventions during IV insertions. For this project, the standardization of topical analgesics for pain prevention interventions is the main focus for decreasing pediatric pain during IV insertion. For this evidence-based project, the purpose is to implement and standardize the use of topical analgesics for pain prevention interventions during peripheral IV insertions for pediatric patients. The aim of this project is as follows: By December 1, 2022, at least 85% of pediatric patients admitted on the inpatient surgical unit at East Tennessee Children’s Hospital, requiring peripheral intravenous access, will receive topical analgesics as a form of pain prevention interventions.
Keywords: pain, peripheral intravenous catheter, pediatrics, interventio
Resistance decay in individuals after antibiotic exposure in primary care: A systematic review and meta-analysis
Abstract Background Antibiotic resistance is an urgent global problem, but reversibility is poorly understood. We examined the development and decay of bacterial resistance in community patients after antibiotic use. Methods This was a systematic review and meta-analysis. PubMed, EMBASE and CENTRAL (from inception to May 2017) were searched, with forward and backward citation searches of the identified studies. We contacted authors whose data were unclear, and of abstract-only reports, for further information. We considered controlled or times-series studies of patients in the community who were given antibiotics and where the subsequent prevalence of resistant bacteria was measured. Two authors extracted risk of bias and data. The meta-analysis used a fixed-effects model. Results Of 24,492 articles screened, five controlled and 20 time-series studies (total 16,353 children and 1461 adults) were eligible. Resistance in Streptococcus pneumoniae initially increased fourfold after penicillin-class antibiotic exposure [odds ratio (OR) 4.2, 95% confidence interval (CI) 3.5–5.4], but this fell after 1 month (OR 1.7, 95% CI 1.3–2.1). After cephalosporin-class antibiotics, resistance increased (OR 2.2, 95%CI 1.7-2.9); and fell to (OR 1.6, 95% CI 1.2-2.3) at 1 month. After macrolide-class antibiotics, resistance increased (OR 3.8, 95% CI 1.9–7.6) and persisted for 1 month (OR 5.2, 95% CI 2.6–10.3) and 3 months (OR 8.1, 95% CI 4.6–14.2, from controlled studies and OR 2.3, 95% CI 0.6–9.4, from time-series studies). Resistance in Haemophilus influenzae after penicillins was not significantly increased (OR 1.3, 95% CI 0.9–1.9) initially but was at 1 month (OR 3.4, 95% CI 1.5–7.6), falling after 3 months (OR 1.0, 95% CI 0.5–2.2). Data were sparse for cephalosporins and macrolides. Resistance in Enterobacter increased post-exposure (OR 3.2, 95% CI 0.9–10.8, from controlled studies and OR 7.1, 95% CI 4.2–12, from time-series studies], but was lower after 1 month (OR 1.8, 95% CI 0.9–3.6). Conclusions Resistance generally increased soon after antibiotic use. For some antibiotic classes and bacteria, it partially diminished after 1 and 3 months, but longer-term data are lacking and urgently needed. Trial registration PROSPERO CRD42015025499
The ISCIP Analyst, Volume VI, Issue 16
This repository item contains a single issue of The ISCIP Analyst, an analytical review journal published from 1996 to 2010 by the Boston University Institute for the Study of Conflict, Ideology, and Policy
The ISCIP Analyst, Volume VI, Issue 20
This repository item contains a single issue of The ISCIP Analyst, an analytical review journal published from 1996 to 2010 by the Boston University Institute for the Study of Conflict, Ideology, and Policy
Deep proteogenomics; high throughput gene validation by multidimensional liquid chromatography and mass spectrometry of proteins from the fungal wheat pathogen Stagonospora nodorum
BACKGROUND: Stagonospora nodorum, a fungal ascomycete in the class dothideomycetes, is a
damaging pathogen of wheat. It is a model for necrotrophic fungi that cause necrotic symptoms via
the interaction of multiple effector proteins with cultivar-specific receptors. A draft genome
sequence and annotation was published in 2007. A second-pass gene prediction using a training set
of 795 fully EST-supported genes predicted a total of 10762 version 2 nuclear-encoded genes, with
an additional 5354 less reliable version 1 genes also retained.
RESULTS: In this study, we subjected soluble mycelial proteins to proteolysis followed by 2D LC
MALDI-MS/MS. Comparison of the detected peptides with the gene models validated 2134 genes.
62% of these genes (1324) were not supported by prior EST evidence. Of the 2134 validated genes,
all but 188 were version 2 annotations. Statistical analysis of the validated gene models revealed a
preponderance of cytoplasmic and nuclear localised proteins, and proteins with intracellularassociated
GO terms. These statistical associations are consistent with the source of the peptides
used in the study. Comparison with a 6-frame translation of the S. nodorum genome assembly
confirmed 905 existing gene annotations (including 119 not previously confirmed) and provided
evidence supporting 144 genes with coding exon frameshift modifications, 604 genes with
extensions of coding exons into annotated introns or untranslated regions (UTRs), 3 new gene
annotations which were supported by tblastn to NR, and 44 potential new genes residing within
un-assembled regions of the genome.
CONCLUSION: We conclude that 2D LC MALDI-MS/MS is a powerful, rapid and economical tool to
aid in the annotation of fungal genomic assemblies
The ISCIP Analyst, Volume VI, Issue 20
This repository item contains a single issue of The ISCIP Analyst, an analytical review journal published from 1996 to 2010 by the Boston University Institute for the Study of Conflict, Ideology, and Policy
The ISCIP Analyst, Volume VII, Issue 4
This repository item contains a single issue of The ISCIP Analyst, an analytical review journal published from 1996 to 2010 by the Boston University Institute for the Study of Conflict, Ideology, and Policy
Tutoring is Real: The Benefits of the Peer Tutor Experience for Future English Educators
In this article, an English education professor, a university writing center administrator, and a recent graduate of an undergraduate English education program discuss the role peer tutoring might play in enhancing the education of preservice teachers of writing. The authors argue that by providing additional, authentic field experiences which reflect constructivist, student-centered philosophies often adhered to in English education programs, university peer tutoring can provide undergraduate students with authentic experience in learning collaboratively, developing rapport with students, and conducting student-centered, one-to-one writing conferences
Understanding Workplace Meetings: A Qualitative Taxonomy of Meeting Purposes
Purpose - Meetings are a workplace activity that deserves increased attention from researchers and practitioners. Previous researchers attempted to develop typologies of meeting purpose with limited success. Through a comparison of classification methodologies, we consider a taxonomy as the appropriate classification scheme for meeting purpose. The goal of our study is to propose a taxonomy of meeting purpose. We then utilize the developed taxonomy to investigate the frequency with which a representative sample of working adults engaged in meetings of these varying purposes. Our proposed taxonomy provides relevant classifications for future research on meetings and serves as a useful tool for managers seeking to use and evaluate the effectiveness of meetings within their organizations.
Design/methodology/approach – This study employs an inductive methodology using discourse analysis of qualitative meeting descriptions to develop a taxomomy of meeting purpose. Our discourse analysis utilizes open-ended survey responses from a sample of working adults (N = 491).
Findings - Our categorical analysis of open-ended questions resulted in a 16 category taxonomy of meeting purpose. The two most prevalent meeting purpose categories in this sample are “to discuss ongoing projects” at 11.6% and “to routinely discuss the state of the business” at 10.8%. The two least common meeting purpose categories in this sample are “to brainstorm for ideas or solutions” at 3.3% and “to discuss productivity and efficiencies” at 3.7%. The taxonomy is analyzed across organizational type and employee job level to identify differences between these important organizational and employee characteristics.
Implications – The data suggest that meetings are institutionalized in organizations making them useful at identifying differences between organizations as well as differences in employees in terms of scope of responsibility. Researchers and managers should consider the purposes for which they call meetings and how that manifests their overarching organizational focus, structure, and goals.
Originality/value - This is the first study to overtly attempt to categorize the various purposes for which meetings are held. Further, this study develops a taxonomy of meeting purposes that will prove useful for investigating the different types of meeting purposes in a broad range of organizational types and structures
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