2 research outputs found
Second malignant neoplasms after treatment of 1487 children and adolescents with acute lymphoblastic leukemiaâA populationâbased analysis of the Austrian ALLâBFM Study Group
Abstract Second malignant neoplasms (SMN) after primary childhood acute lymphoblastic leukemia (ALL) are rare. Among 1487 ALL patients diagnosed between 1981 and 2010 in Austria, the 10âyear cumulative incidence of an SMN was 1.1% ± 0.3%. There was no difference in the 10âyear incidence of SMNs with regard to diagnosticâ, responseâ and therapyârelated ALL characteristics except for a significantly higher incidence in patients with leukocytes â„50.0 G/L at ALL diagnosis (2.1% ± 1.0% vs. 0% for 20.0â50.0 G/L, and 1.0% ± 0.3% for < 20.0 G/L; p = 0.033). Notably, there was no significant difference in the incidence of SMNs between patients with or without cranial radiotherapy (1.2% ± 0.5% vs. 0.8% ± 0.3%; p = 0.295). Future strategies must decrease the incidence of SMNs, as this event still leads to death in oneâthird (7/19) of the patients