Correlation between serum C-reactive protein level and endothelial function in patients with type2 diabetes mellitus

published_or_final_versio

The moderating effects of gratitude on the association between perceived parenting styles and suicidal ideation

202208 bcchSelf-funde

Inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus

Symposium on Endocrine Surger

Atorvastatin lowers C-reactive protein and improves endothelium-dependent vasodilation in type 2 diabetes mellitus

Endothelial dysfunction is frequently found in diabetic subjects. This study was performed to investigate whether atorvastatin therapy was able to reverse endothelial dysfunction in type 2 diabetes and, if so, whether the effect was due to its antiinflammatory action. Eighty patients (baseline low density lipoprotein, 4.37 ± 0.71 mmol/liter) were randomized to atorvastatin (10 mg daily for 3 months, followed by 20 mg daily for 3 months) or placebo in a double blind study. Endothelial function was assessed by high resolution vascular ultrasound, and high sensitivity C-reactive protein (CRP) was assessed by immunoturbidimetric assay. Diabetic patients had higher CRP (P < 0.01) than matched nondiabetic controls, and both endothelium-dependent and independent vasodilation were impaired (P < 0.01). Atorvastatin (10 and 20 rog) lowered plasma cholesterol by 32.9% and 38.0%, triglyceride by 15.4% and 23.1%, and low density lipoprotein by 43.4% and 50.1%, respectively. At 6 months, plasma CRP decreased in the atorvastatin group compared with baseline (P < 0.05). Endothelium-dependent vasodilation improved in the atorvastatin group compared with the placebo group (P < 0.05). The percent change in endothelium-dependent vasodilation at 6 months correlated with the percent change in CRP (r = -0.44; P < 0.05), but not with changes in plasma lipids. In conclusion, treatment with atorvastatin in type 2 diabetes led to a significant improvement in endothelium-dependent vasodilation, which might be partly related to its anti-inflammatory effect.link_to_subscribed_fulltex

Atorvastatin lowers C-reactive protein and improves endothelial dysfunction in type 2 diabetes mellitus

Symposium on Endocrine Surger

Corrigendum: A multidimensional PERMA-H positive education model, general satisfaction of school life, and character strengths use in Hong Kong senior primary school students : confirmatory factor analysis and path analysis using the APASO-II [Front. Psychol., 9, 1090, (2018)] doi: 10.3389/fpsyg.2018.01090

201902 bcmaVersion of RecordPublishe

A multidimensional PERMA-H positive education model, general satisfaction of school life, and character strengths use in Hong Kong senior primary school students : confirmatory factor analysis and path analysis using the APASO-II

2017-2018 > Academic research: refereed > Publication in refereed journal201810 bcrcVersion of RecordPublishe

Effects of a mindful parenting workshop for parents of adolescents and young adults following social unrest in Hong Kong

202208 bcchOthersPublic Policy Research Scheme (Special Round)12 month