Socially structured games

We generalize the concept of a cooperative non-transferable utility game by introducing a socially structured game. In a socially structured game every coalition of players can organize themselves according to one or more internal organizations to generate payoffs. Each admissible internal organization on a coalition yields a set of payoffs attainable by the members of this coalition. The strengths of the players within an internal organization depend on the structure of the internal organization and are represented by an exogenously given power vector. More powerful players have the power to take away payoffs of the less powerful players as long as those latter players are not able to guarantee their payoffs by forming a different internal organization within some coalition in which they have more power.we introduce the socially stable core as a solution concept that contains those payoffs that are both stable in an economic sense, i.e., belong to the core of the underlying cooperative game, and stable in a social sense, i.e., payoffs are sustained by a collection of internal organizations of coalitions for which power is distributed over all players in a balanced way. The socially stable core is a subset and therefore a refinement of the core. We show by means of examples that in many cases the socially stable core is a very small subset of the core.we will state conditions for which the socially stable core is non-empty. In order to derive this result, we formulate a new intersection theorem that generalizes the kkms intersection theorem. We also discuss the relationship between social stability and the wellknown concept of balancedness for ntu-games, a sufficient condition for non-emptiness of the core. In particular we give an example of a socially structured game that satisfies social stability and therefore has a non-empty core, but whose induced ntu-game does not satisfy balancedness in the general sense of billera

Combinatorial integer labeling theorems on finite sets with applications

Tucker’s well-known combinatorial lemma states that, for any given symmetric triangulation of the n-dimensional unit cube and for any integer labeling that assigns to each vertex of the triangulation a label from the set {±1, ±2, · · · , ±n} with the property that antipodal vertices on the boundary of the cube are assigned opposite labels, the triangulation admits a 1-dimensional simplex whose two vertices have opposite labels. In this paper, we are concerned with an arbitrary finite set D of integral vectors in the n-dimensional Euclidean space and an integer labeling that assigns to each element of D a label from the set {±1, ±2, · · · , ±n}. Using a constructive approach, we prove two combinatorial theorems of Tucker type. The theorems state that, under some mild conditions, there exists two integral vectors in D having opposite labels and being cell-connected in the sense that both belong to the set {0, 1} n +q for some integral vector q. These theorems are used to show in a constructive way the existence of an integral solution to a system of nonlinear equations under certain natural conditions. An economic application is provided

Advances in imaging to support the development of novel therapies for multiple sclerosis.

Multiple sclerosis (MS) is a common neurological disease in North America and Europe. Although most patients develop major locomotor disability over the course of 15-20 years, in approximately one-third of patients the long-term course is favorable, with minimal disability. Although current disease-modifying treatments reduce the relapse rate, their long-term effects are uncertain. MS treatment trials are challenging because of the variable clinical course and typically slow evolution of the disease. Magnetic resonance imaging (MRI) is sensitive in monitoring MS pathology and facilitates evaluation of potential new treatments. MRI measurements of lesion activity have identified new immunomodulatory treatments for preventing relapse. Quantitative measurements of tissue volume and structural integrity, capable of detecting neuroprotection and repair, should facilitate new treatments designed to prevent irreversible disability. Higher-field MR scanners and new positron emission tomography (PET) radioligands are providing new insights into cellular and pathophysiological abnormalities, and should be valuable in future therapeutic trials. Retinal axonal loss measured using optical coherence tomography (OCT) can assess acute neuroprotection in optic neuritis