4 research outputs found
A VERITAS/Breakthrough Listen Search for Optical Technosignatures
The Breakthrough Listen Initiative is conducting a program using multiple
telescopes around the world to search for "technosignatures": artificial
transmitters of extraterrestrial origin from beyond our solar system. The
VERITAS Collaboration joined this program in 2018, and provides the capability
to search for one particular technosignature: optical pulses of a few
nanoseconds duration detectable over interstellar distances. We report here on
the analysis and results of dedicated VERITAS observations of Breakthrough
Listen targets conducted in 2019 and 2020 and of archival VERITAS data
collected since 2012. Thirty hours of dedicated observations of 136 targets and
249 archival observations of 140 targets were analyzed and did not reveal any
signals consistent with a technosignature. The results are used to place limits
on the fraction of stars hosting transmitting civilizations. We also discuss
the minimum-pulse sensitivity of our observations and present VERITAS
observations of CALIOP: a space-based pulsed laser onboard the CALIPSO
satellite. The detection of these pulses with VERITAS, using the analysis
techniques developed for our technosignature search, allows a test of our
analysis efficiency and serves as an important proof-of-principle.Comment: 15 pages, 7 figure
VERITAS discovery of very high energy gamma-ray emission from S3 1227+25 and multiwavelength observations
We report the detection of very high energy gamma-ray emission from the
blazar S3 1227+25 (VER J1230+253) with the Very Energetic Radiation Imaging
Telescope Array System (VERITAS). VERITAS observations of the source were
triggered by the detection of a hard-spectrum GeV flare on May 15, 2015 with
the Fermi-Large Area Telescope (LAT). A combined five-hour VERITAS exposure on
May 16th and May 18th resulted in a strong 13 detection with a
differential photon spectral index, = 3.8 0.4, and a flux level
at 9% of the Crab Nebula above 120 GeV. This also triggered target of
opportunity observations with Swift, optical photometry, polarimetry and radio
measurements, also presented in this work, in addition to the VERITAS and
Fermi-LAT data. A temporal analysis of the gamma-ray flux during this period
finds evidence of a shortest variability timescale of = 6.2
0.9 hours, indicating emission from compact regions within the jet, and the
combined gamma-ray spectrum shows no strong evidence of a spectral cut-off. An
investigation into correlations between the multiwavelength observations found
evidence of optical and gamma-ray correlations, suggesting a single-zone model
of emission. Finally, the multiwavelength spectral energy distribution is well
described by a simple one-zone leptonic synchrotron self-Compton radiation
model.Comment: 18 pages, 6 figures. Accepted for publication in the Astrophysical
Journal (ApJ
The Turn-Down of the Baryonic Tully-Fisher Relation at Low Galaxy Masses
The ratio of baryonic to dark matter in present-day galaxies constrains
galaxy formation theories and can be determined empirically via the baryonic
Tully-Fisher relation (BTFR), which compares a galaxy's baryonic mass
(M) to its maximum rotation velocity (V). The BTFR is
well-determined at M M, but poorly constrained at lower
masses due to small samples and the challenges of measuring rotation velocities
in this regime. For 25 galaxies with high-quality data and M
M, we estimate M from infrared, optical, and HI observations
and Vmax from the HI gas rotation. Many of the V values are lower
limits because the velocities are still rising at the edge of the detected HI
disks; consequently, most of our sample has lower velocities than expected from
extrapolations of the BTFR at higher masses. To estimate V, we map each
galaxy to a dark matter halo assuming density profiles with and without cores,
and find that the cored profiles match the data better. When we compare the
V values derived from the cored density profiles to our M
measurements, we find a turndown of the BTFR at low masses that is consistent
with CDM predictions and implying baryon fractions of 1-10% of the cosmic
value. Although we are limited by the sample size and assumptions inherent in
mapping measured rotational velocities to theoretical rotation curves, our
results suggest that the galaxy formation efficiency drops at masses below
M M, corresponding to M
M.Comment: 36 pages, 3 tables, 23 figure
Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics
Abstract Novel drug discoveries have shifted the treatment paradigms of most hematological malignancies, including multiple myeloma (MM). However, this plasma cell malignancy remains incurable, and novel therapies are therefore urgently needed. Whole-genome transcriptome analyses in a large cohort of MM patients demonstrated that alterations in pre-mRNA splicing (AS) are frequent in MM. This manuscript describes approaches to identify disease-specific alterations in MM and proposes RNA-based therapeutic strategies to eradicate such alterations. As a “proof of concept”, we examined the causes of aberrant HMMR (Hyaluronan-mediated motility receptor) splicing in MM. We identified clusters of single nucleotide variations (SNVs) in the HMMR transcript where the altered splicing took place. Using bioinformatics tools, we predicted SNVs and splicing factors that potentially contribute to aberrant HMMR splicing. Based on bioinformatic analyses and validation studies, we provided the rationale for RNA-based therapeutic strategies to selectively inhibit altered HMMR splicing in MM. Since splicing is a hallmark of many cancers, strategies described herein for target identification and the design of RNA-based therapeutics that inhibit gene splicing can be applied not only to other genes in MM but also more broadly to other hematological malignancies and solid tumors as well