Alteration of Coagulation Profiles in Hypothyroid Patients

Background: Hypothyroidism is an underactive thyroid gland that results in too little thyroid hormones in circulation causing a slowdown in metabolism, therefor hypothyroid modifies physiological process of primary and secondary hemostasis and may lead to a higher bleeding risk. Objectives: The aim of this study is to assess the coagulation profiles [Prothrombin Time (PT), International Normalize Ratio (INR), Activated Partial Thromboplastin Time (PTT)] in patients with hypothyroidism. Methodology: This is a case-control hospital-based study carried out at the National Cancer Institute – University of Gezira (NCI-UG), Wad Medani, Sudan from January to October 2020. A total of 100 (50 patients with hypothyroidism as cases (38.50 ± 10.46 years) matched with 50 normal healthy individuals as controls (35.52 ± 11.64 years) participated in this study. Two ml of venous blood sample was collected in a trisodium citrate container. Coagulation profiles (PT, INR, and PTT) were measured using a Coatron M4 coagulometer. SPSS computer program (v 21.0) was used for data analysis. Results: The prolonged PTT account for 74%. The average PTT of cases (42.29 ± 7.22 sec) was higher than controls (32.67 ± 5.90 sec) giving highly statistically significant differences (P value = 0.000) between them. There were significant differences in PTT between mild and severe hypothyroidism (P value = 0.0470). PTT had significant positive correlation within TSH (P value = 0.048; r = 0.070) and significant negative correlation within T3 (P value = 0.000; r = - 0.490) and T4 (P value = 0.020; r = - 520; P value = 000). Conclusion: The study concluded that PTT was significantly higher in a patient with hypothyroidism when compared to the control. PTT results showed there was a significant negative correlation between T3 and T4 levels and a significant positive correlation with TSH levels. So, PTT should be included as a follow-up routine test for patients with hypothyroidism. Keywords: Prothrombin time, International Normalized Ratio, Partial Thromboplastin Time, Hypothyroidism, Sudan

Alteration of Coagulation Profiles in Hypothyroid Patients

Background: Hypothyroidism is an underactive thyroid gland that results in too little thyroid hormones in circulation causing a slowdown in metabolism, therefor hypothyroid modifies physiological process of primary and secondary hemostasis and may lead to a higher bleeding risk. Objectives: The aim of this study is to assess the coagulation profiles [Prothrombin Time (PT), International Normalize Ratio (INR), Activated Partial Thromboplastin Time (PTT)] in patients with hypothyroidism. Methodology: This is a case-control hospital-based study carried out at the National Cancer Institute – University of Gezira (NCI-UG), Wad Medani, Sudan from January to October 2020. A total of 100 (50 patients with hypothyroidism as cases (38.50 ± 10.46 years) matched with 50 normal healthy individuals as controls (35.52 ± 11.64 years) participated in this study. Two ml of venous blood sample was collected in a trisodium citrate container. Coagulation profiles (PT, INR, and PTT) were measured using a Coatron M4 coagulometer. SPSS computer program (v 21.0) was used for data analysis. Results: The prolonged PTT account for 74%. The average PTT of cases (42.29 ± 7.22 sec) was higher than controls (32.67 ± 5.90 sec) giving highly statistically significant differences (P value = 0.000) between them. There were significant differences in PTT between mild and severe hypothyroidism (P value = 0.0470). PTT had significant positive correlation within TSH (P value = 0.048; r = 0.070) and significant negative correlation within T3 (P value = 0.000; r = - 0.490) and T4 (P value = 0.020; r = - 520; P value = 000). Conclusion: The study concluded that PTT was significantly higher in a patient with hypothyroidism when compared to the control. PTT results showed there was a significant negative correlation between T3 and T4 levels and a significant positive correlation with TSH levels. So, PTT should be included as a follow-up routine test for patients with hypothyroidism. Keywords: Prothrombin time, International Normalized Ratio, Partial Thromboplastin Time, Hypothyroidism, Sudan

Assessment of coagulation profiles among sudanese psychiatric patients under antipsychotic drugs attending Hassan Allob Mental Hospital, Gezira State, Sudan (2020)

Background: Psychiatric disorder is a mental illness diagnosed by a mental health professional that greatly disorders thinking. A psychotropic drug is a chemical substance that crosses the blood brain barrier (BBB) and acts primarily upon the central nervous system (CNS), where it affects brain function, resulting in change in perception, mood, consciousness, cognition, and behavior.  It causes changes in platelet function, plasma coagulation, or fibrinolysis seemed more likely to be responsible for the increase in thrombotic events. Objectives: The aim of this study was to assess the coagulation profiles [Prothrombin Time (PT), International Normalize Ratio (INR), Activated Partial Thromboplastin Time (APTT)] in psychiatric patients under antipsychotic drug administration. Methodology: This is a case-control hospital-based study carried out in Hassan Allob Mental Hospital, Gezira State, Sudan from January to September 2020. A total of 50 psychiatric patients under antipsychotic drug administration as cases (35.52 ± 11.64 years) and 50 normal healthy individuals as controls (32.68 ± 4.85 years) participated in this study. Two ml of venous blood samples were collected from all participants in trisodium citrate container. Coagulation profiles (PT, INR, and APTT) were measured using a Coatron M4 coagulometer. SPSS computer program (v 22.0) was used for data analysis