Beaming Binaries - a New Observational Category of Photometric Binary Stars

The new photometric space-borne survey missions CoRoT and Kepler will be able to detect minute flux variations in binary stars due to relativistic beaming caused by the line-of-sight motion of their components. In all but very short period binaries (P>10d), these variations will dominate over the ellipsoidal and reflection periodic variability. Thus, CoRoT and Kepler will discover a new observational class: photometric beaming binary stars. We examine this new category and the information that the photometric variations can provide. The variations that result from the observatory heliocentric velocity can be used to extract some spectral information even for single stars.Comment: 15 pages, 4 figures, accpeted for publication in The Astrophysical Journa

Correcting HIRES radial velocities for small systematic errors

The HIRES spectrograph, mounted on the $10$-m Keck-I telescope, belongs to a small group of radial-velocity (RV) instruments that produce stellar RVs with long-term precision down to $\sim1$ ms$^{-1}$. In $2017$, the HIRES team published $64,480$ RVs of $1,699$ stars, collected between $1996$ and $2014$. In this bank of RVs, we identify a sample of RV-quiet stars, whose RV scatter is $<10$ ms$^{-1}$, and use them to reveal two small but significant nightly zero-point effects: a discontinuous jump, caused by major modifications of the instrument in August $2004$, and a long-term drift. The size of the $2004$ jump is $1.5\pm0.1$ ms$^{-1}$, and the slow zero-point variations have a typical magnitude of $\lesssim1$ ms$^{-1}$. In addition, we find a small but significant correlation between stellar RVs and the time relative to local midnight, indicative of an average intra-night drift of $0.051\pm0.004$ ms$^{-1}$hr$^{-1}$. We correct the $64,480$ HIRES RVs for the systematic effects we find, and make the corrected RVs publicly available. Our findings demonstrate the importance of observing RV-quiet stars, even in the era of simultaneously-calibrated RV spectrographs. We hope that the corrected HIRES RVs will facilitate the search for new planet candidates around the observed stars.Comment: 5 pages, 7 figure

Combining chromosomal arm status and significantly aberrant genomic locations reveals new cancer subtypes

Many types of tumors exhibit chromosomal losses or gains, as well as local amplifications and deletions. Within any given tumor type, sample specific amplifications and deletionsare also observed. Typically, a region that is aberrant in more tumors,or whose copy number change is stronger, would be considered as a more promising candidate to be biologically relevant to cancer. We sought for an intuitive method to define such aberrations and prioritize them. We define V, the volume associated with an aberration, as the product of three factors: a. fraction of patients with the aberration, b. the aberrations length and c. its amplitude. Our algorithm compares the values of V derived from real data to a null distribution obtained by permutations, and yields the statistical significance, p value, of the measured value of V. We detected genetic locations that were significantly aberrant and combined them with chromosomal arm status to create a succint fingerprint of the tumor genome. This genomic fingerprint is used to visualize the tumors, highlighting events that are co ocurring or mutually exclusive. We allpy the method on three different public array CGH datasets of Medulloblastoma and Neuroblastoma, and demonstrate its ability to detect chromosomal regions that were known to be altered in the tested cancer types, as well as to suggest new genomic locations to be tested. We identified a potential new subtype of Medulloblastoma, which is analogous to Neuroblastoma type 1.Comment: 34 pages, 3 figures; to appear in Cancer Informatic

Spectroscopic Binary Mass Determination using Relativity

High-precision radial-velocity techniques, which enabled the detection of extrasolar planets are now sensitive to relativistic effects in the data of spectroscopic binary stars (SBs). We show how these effects can be used to derive the absolute masses of the components of eclipsing single-lined SBs and double-lined SBs from Doppler measurements alone. High-precision stellar spectroscopy can thus substantially increase the number of measured stellar masses, thereby improving the mass-radius and mass-luminosity calibrations.Comment: 10 pages, 1 figure, accepted for publication by the Astrophysical Journal Letter

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled iNKT cell gene expression during ontogeny and in peripheral subsets as part of the Immunological Genome Project (ImmGen). High-resolution comparative transcriptional analyses defined developmental and subset-specific iNKT cell gene expression programs. In addition, iNKT cells were found to share an extensive transcriptional program with natural killer (NK) cells, similar in magnitude to that shared with major histocompatibility complex (MHC)-restricted T cells. Strikingly, the NK- iNKT program also operated constitutively in γδT cells and in adaptive T cells following activation. Together, our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes

Is Image Memorability Prediction Solved?

This paper deals with the prediction of the memorability of a given image. We start by proposing an algorithm that reaches human-level performance on the LaMem dataset - the only large scale benchmark for memorability prediction. The suggested algorithm is based on three observations we make regarding convolutional neural networks (CNNs) that affect memorability prediction. Having reached human-level performance we were humbled, and asked ourselves whether indeed we have resolved memorability prediction - and answered this question in the negative. We studied a few factors and made some recommendations that should be taken into account when designing the next benchmark

Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10

Ubiquitylation is a posttranslational modification that determines protein fate. The ubiquitin code is written by enzymatic cascades of E1 and E2 and E3 enzymes. Ubiquitylation can be edited or erased by deubiquitylating enzymes. Ub-receptors are proteins that read and decipher the ubiquitin codes into cellular response. They harbor a ubiquitin-binding domain and a response element. Interestingly, Ub-receptors are also regulated by ubiquitylation and deubiquitylation. However, until recently, the molecular details and the significance of this regulation remained enigmatic. Rpn10 is a Ub-receptor that shuttles ubiquitylated targets to the proteasome for degradation. Here we review recent data on Rpn10, with emphasis on its regulation by ubiquitylation

Occurrence rates of small planets from HARPS: Focus on the Galactic context

Context. The stars in the Milky Way thin and thick disks can be distinguished by several properties such as metallicity and kinematics. It is not clear whether the two populations also differ in the properties of planets orbiting the stars. In order to study this, a careful analysis of both the chemical composition and mass detection limits is required for a sufficiently large sample. Currently, this information is still limited only to large radial-velocity (RV) programs. Based on the recently published archival database of the High Accuracy Radial velocity Planet Searcher (HARPS) spectrograph, we present a first analysis of low-mass (small) planet occurrence rates in a sample of thin- and thick-disk stars. Aims. We aim to assess the effects of stellar properties on planet occurrence rates and to obtain first estimates of planet occurrence rates in the thin and thick disks of the Galaxy. As a baseline for comparison, we also aim to provide an updated value for the small close-in planet occurrence rate and compare it to results of previous RV and transit ($\textit{Kepler}$) works. Methods. We used archival HARPS RV datasets to calculate detection limits of a sample of stars that were previously analysed for their elemental abundances. For stars with known planets we first subtracted the Keplerian orbit. We then used this information to calculate planet occurrence rates according to a simplified Bayesian model in different regimes of stellar and planet properties. Results. Our results suggest that metal-poor stars and more massive stars host fewer low-mass close-in planets. We find the occurrence rates of these planets in the thin and thick disks to be comparable. In the iron-poor regimes, we find these occurrence rates to be significantly larger at the high-$\alpha$ region (thick-disk stars) as compared with the low-$\alpha$ region (thin-disk stars). In general, we find the...Comment: 10 pages, 6 figures, accepted for publication in A&