Connecting the Sun and the Solar Wind: The First 2.5 Dimensional Self-consistent MHD Simulation under the Alfv\'en Wave Scenario

The solar wind emanates from the hot and tenuous solar corona. Earlier studies using 1.5 dimensional simulations show that Alfv\'{e}n waves generated in the photosphere play an important role in coronal heating through the process of non-linear mode conversion. In order to understand the physics of coronal heating and solar wind acceleration together, it is important to consider the regions from photosphere to interplanetary space as a single system. We performed 2.5 dimensional, self-consistent magnetohydrodynamic simulations, covering from the photosphere to the interplanetary space for the first time. We carefully set up the grid points with spherical coordinate to treat the Alfv\'{e}n waves in the atmosphere with huge density contrast, and successfully simulate the solar wind streaming out from the hot solar corona as a result of the surface convective motion. The footpoint motion excites Alfv\'{e}n waves along an open magnetic flux tube, and these waves traveling upwards in the non-uniform medium undergo wave reflection, nonlinear mode conversion from Alfv\'{e}n mode to slow mode, and turbulent cascade. These processes leads to the dissipation of Alfv\'{e}n waves and acceleration of the solar wind. It is found that the shock heating by the dissipation of the slow mode wave plays a fundamental role in the coronal heating process whereas the turbulent cascade and shock heating drive the solar wind.Comment: 7 pages, 7 figures, accepted for publication in Ap

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome

3q29 microdeletion, a rare recurrent copy number variant (CNV), greatly confers an increased risk of psychiatric disorders, such as schizophrenia and autism spectrum disorder (ASD), as well as intellectual disability. However, disease-relevant cellular phenotypes of 3q29 deletion syndrome remain to be identified. To reveal the molecular and cellular etiology of 3q29 deletion syndrome, we generated a mouse model of human 3q29 deletion syndrome by chromosome engineering, which achieved construct validity. 3q29 deletion (Df/+) mice showed reduced body weight and brain volume and, more importantly, impaired social interaction and prepulse inhibition. Importantly, the schizophrenia-related impaired prepulse inhibition was reversed by administration of antipsychotics. These findings are reminiscent of the growth defects and neuropsychiatric behavioral phenotypes in patients with 3q29 deletion syndrome and exemplify that the mouse model achieves some part of face validity and predictive validity. Unbiased whole-brain imaging revealed that neuronal hyperactivation after a behavioral task was strikingly exaggerated in a restricted region of the cortex of Df/+ mice. We further elucidated the cellular phenotypes of neuronal hyperactivation and the reduction of parvalbumin expression in the cortex of Df/+ mice. Thus, the 3q29 mouse model provides invaluable insight into the disease-causative molecular and cellular pathology of psychiatric disorders

Inverted Pendulum-type Personal Mobility Considering Human Vibration Sensitivity

Bruit Guy. Mohammed Harbi et Gilbert Meynier, Le FLN. Documents et histoire 1954-1962, 2004 ; Mohammed Harbi et Benjamin Stora, La guerre d'Algérie, 1954-1962. La fin de l'amnésie, 2004. In: Raison présente, n°149-150, 1er trimestre 2004. Une laïcité pour l'avenir. pp. 260-264