Pathologically Proven Intraocular Infiltration With Adult T-Cell Leukemia/Lymphoma: Two New Cases With Either Vitreous Opacity or Aqueous Hypopyon and Literature Review of 16 Cases

This study reported 2 new patients and 16 historical cases with pathologically proven intraocular infiltration with adult T-cell leukemia and lymphoma (ATLL) to know the timing of intraocular infiltration in the disease course. The first case was a 67-year-old woman who developed bilateral vitreous opacity about half a year after the onset of acute type of ATLL that had been unresponsive to chemotherapy. She underwent vitrectomy combined with cataract surgery in both eyes. She had bilateral optic disc atrophy and localized retinal white infiltrates in both eyes. Cytological examination of vitreous aspirates demonstrated medium-sized cells with aberrant flower-like convoluted nuclei, positive for CD3, and thus indicative of T-cells. The second case was a 38-year-old man who was diagnosed acute type of ATLL at the presentation of acute kidney injury. About half a year after initial chemotherapy and allogeneic hematopoietic stem cell transplantation, he developed aqueous hypopyon in the right eye, concurrent with cutaneous and central nervous system relapse. Aqueous tap disclosed class V abnormal cells. The aqueous “pseudohypopyon” resolved in response to another round of chemotherapy with mogamulizumab. In review of 18 patients, intraocular infiltration with ATLL was diagnosed by vitrectomy in 9, aqueous tap in 3, chorioretinal biopsy in 3, and autopsy in 3. The intraocular infiltration developed concurrently with systemic diagnosis of ATLL in 5 patients, but developed later after chemotherapy in 13. In conclusion, intraocular infiltration with ATLL appears rare, and pathological diagnosis by vitrectomy and aqueous tap would help determine therapeutic plan in relapse after chemotherapy

Three-dimensional stress state above and below the plate boundary fault after the 2011 Mw 9.0 Tohoku earthquake

東北地方太平洋沖地震を引き起こしたプレート境界断層より以深の応力状態を初めて決定 --海洋底掘削で採取されたコア試料の非弾性ひずみ解析からのアプローチ--. 京都大学プレスリリース. 2022-11-11.Finding faults deeply stressful: First investigation of stress state below plate boundary fault of Tohoku earthquake. 京都大学プレスリリース. 2022-12-09.The Integrated Ocean Drilling Program conducted Expedition 343 and 343T, named the Japan Trench Fast Drilling Project (JFAST), to drill through the plate boundary fault that ruptured during the 2011 Mw 9.0 Tohoku earthquake in the area with the largest fault slip displacement near the Japan trench. Analyses of breakouts observed from borehole C0019B produced postearthquake stress states above the plate boundary fault between the subducting Pacific plate and overriding North American plate. To supplement the lack of stress data below the rupture zone of the earthquake, we conducted core-based three-dimensional stress measurements by the anelastic strain recovery (ASR) method using four whole-round core samples of sediments, of which three samples were located above, but one sample was located below the plate boundary fault in borehole C0019E. As a result of the stress measurements, the postearthquake three-dimensional stress magnitudes at ∼802 and ∼828 meters below seafloor (mbsf) across the plate boundary fault at ∼820 mbsf reveal a normal faulting stress regime. The differences between the three-dimensional intermediate principal stress and the minimum principal stress at the two depths are less than 1 MPa, suggesting a complete release of horizontal tectonic stresses that accumulated before the earthquake. In addition, the maximum horizontal stress S[Hmax] azimuth N115°E at ∼828 mbsf below the plate boundary fault from ASR measurements shows consistency with the S[Hmax] azimuth N139 ± 23°E (mean ± standard deviation) at ∼550–810 mbsf from breakout analyses above the fault. Taken together with the similar stress magnitudes at ∼802 and ∼828 mbsf, we interpret that the postearthquake stress states are almost the same in the sediments above and below the plate boundary fault. In other words, the stress state in terms of both orientation and magnitude is continuous across the fault. At a shallower depth of ∼177 mbsf in the slope sediments, the ASR stress data reveal a “stress state at rest”, which is likely free from tectonic effects of plate subduction, suggesting that the stress state was reset by the great coseismic displacement of ∼50 m slipped during the Tohoku earthquake

Development of High Efficiency Swing Compressor for R32 Refrigerant

In the age of global warming, energy saving features and overall reduction of environmental impact are critical components that must be addressed when developing new HVAC units. We chose the R32 refrigerant, with its lower LCCP as a more sustainable choice than the R410A. However, R32 has its drawbacks. Due to its smaller molecular weight, internal leakage loss is higher for the R32. Moreover, high discharge gas temperature decrease the reliability of the compressor, and make a large overheating loss increase. In this study, we will describe the technologies that were developed to overcome these drawbacks. We will also present the performance and reliability of the newly developed high efficiency swing compressor series for R32 refrigerants

Carbon monoxide: impact on remethylation/transsulfuration metabolism and its pathophysiologic implications

Carbon monoxide (CO) is a gaseous product generated by heme oxygenase (HO), which oxidatively degrades heme. While the stress-inducible HO-1 has well been recognized as an anti-oxidative defense mechanism under stress conditions, recent studies suggest that cancer cells utilize the reaction for their survival. HO-2, the constitutive isozyme, also plays protective roles as a tonic regulator for neurovascular function. Although protective roles of the enzyme reaction and CO have extensively been studied, little information is available on the molecular mechanisms by which the gas exerts its biological actions. Recent studies using metabolomics revealed that CO inhibits cystathionine β-synthase (CBS), which generates H2S, another gaseous mediator. The CO-dependent CBS inhibition may impact on the remethylation cycle and related metabolic pathways including the methionine salvage pathway and polyamine synthesis. This review focuses on the gas-responsive regulation of metabolic systems, particularly the remethylation and transsulfuration pathways, and their putative implications for cancer and ischemic diseases

Nitrogen Fixation in Soybean Nodules Affects Seed Protein and Oil Contents: The Suggested Mechanism from the Coordinated Changes of Seed Chemical Compositions and Phosphoenolpyruvate Carboxylase Activity Caused by Different Types of Nitrogen Fertilizer

The contents of seed storage compounds, protein and oil, determine the best use of soybean seeds, namely materials for food processing and oil production. Genetic and environmental factors could affect the chemical compositions of soybean seeds. However, the mechanisms of how the accumulation of these primary seed compounds is regulated are mostly unclear. In this chapter, we describe the different effects of nodulation on the protein and oil contents in soybean seeds and the crucial role of phosphoenolpyruvate carboxylase (PEPC) in the protein accumulation of soybean seeds. Based on our previous studies on soybean seeds, we introduce five manners deduced; (1) protein accumulation is independent of oil accumulation, (2) nitrogen fixation results in decreasing oil amount per seed and decreased seed oil content, (3) a high pseudo negative correlation between protein and oil contents in seeds is likely to be observed under less nitrogen supply from the soil, (4) nitrogen absorbed from soil during the late growth stage promote seed production, (5) plant-type PEPC, ex. Gmppc2 in soybean could play a role in amino acid biosynthesis for storage protein accumulation in seeds during the late maturation period

Inhibition of Ca2+/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats

<p>Abstract</p> <p>Background</p> <p>Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes severe peripheral neuropathy. We previously reported that oxaliplatin (4 mg/kg, i.p., twice a week) induces mechanical allodynia in the late phase in rats, and that spinal NR2B-containig <it>N</it>-methyl-_D-aspartate (NMDA) receptors are involved in the oxaliplatin-induced mechanical allodynia. In the present study, we investigated the involvement of Ca²⁺/calmodulin dependent protein kinase II (CaMKII), which is a major intracellular protein kinase and is activated by NMDA receptor-mediated Ca²⁺influx, in the oxaliplatin-induced mechanical allodynia in rats.</p> <p>Results</p> <p>An increase of CaMKII phosphorylation was found in the spinal cord (L_4-6) of oxaliplatin-treated rats. This increased CaMKII phosphorylation was reversed by intrathecal injection of a selective CaMKII inhibitor KN-93 (50 nmol, i.t.) and a selective NR2B antagonist Ro 25-6981 (300 nmol, i.t.). Moreover, acute administration of KN-93 (50 nmol, i.t.) strongly reversed the oxaliplatin-induced mechanical allodynia in von Frey test, while it did not affect the oxaliplatin-induced cold hyperalgesia in acetone test. Similarly, oral administration of trifluoperazine (0.1 and 0.3 mg/kg, p.o.), which is an antipsychotic drug and inhibits calmodulin, reduced both mechanical allodynia and increased CaMKII phosphorylation. On the other hand, trifluoperazine at the effective dose (0.3 mg/kg) had no effect on the paw withdrawal threshold in intact rats. In addition, trifluoperazine at the same dose did not affect the motor coordination in rota-rod test in intact and oxaliplatin-treated rats.</p> <p>Conclusions</p> <p>These results suggest that CaMKII is involved in the oxaliplatin-induced mechanical allodynia, and trifluoperazine may be useful for the treatment of oxaliplatin-induced peripheral neuropathy in clinical setting.</p

Mucinous Carcinoma of the Breast: Clinicopathological Features and Long-term Prognosis in Comparison with Invasive Ductal Cancer; A Single Hospital’s 30+-Year Experience

Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). A Cox regression analysis demonstrated that MC tended to be an independent prognostic factor (hazard ratio 0.44, p=0.098). The BSS of the MC patients with positive lymph node (LN) metastasis was significantly poorer than that of the patients without it, by univariate analysis (p=0.002). The tumor size in the MC patients with positive LN metastasis (mean 3.2 cm) was significantly larger than that in the patients without it (mean 1.9 cm) (p=0.0004). Although a Cox regression analysis revealed no independent factor, MC patients with positive LN metastasis should be treated for advanced invasive ductal breast cancer