Study on Effective Inundation Analysis Method Considering Characteristics of Ground Elevation in Calculation Grid

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Parameter-free accelerated gradient descent for nonconvex minimization

We propose a new first-order method for minimizing nonconvex functions with a Lipschitz continuous gradient and Hessian. The proposed method is an accelerated gradient descent with two restart mechanisms and finds a solution where the gradient norm is less than $\epsilon$ in $O(\epsilon^{-7/4})$ function and gradient evaluations. Unlike existing algorithms with similar complexity bounds, our method is parameter-free because it requires no prior knowledge of problem-dependent parameters, e.g., the Lipschitz constants and the target accuracy $\epsilon$. The main challenge in achieving this advantage is estimating the Lipschitz constant of the Hessian using only first-order information. To this end, we develop a new Hessian-free analysis based on two technical inequalities: a Jensen-type inequality for the gradient and an error bound for the trapezoidal rule. Several numerical results illustrate the practicality and robustness of the proposed method

Optimal Transport with Cyclic Symmetry

We propose novel fast algorithms for optimal transport (OT) utilizing a cyclic symmetry structure of input data. Such OT with cyclic symmetry appears universally in various real-world examples: image processing, urban planning, and graph processing. Our main idea is to reduce OT to a small optimization problem that has significantly fewer variables by utilizing cyclic symmetry and various optimization techniques. On the basis of this reduction, our algorithms solve the small optimization problem instead of the original OT. As a result, our algorithms obtain the optimal solution and the objective function value of the original OT faster than solving the original OT directly. In this paper, our focus is on two crucial OT formulations: the linear programming OT (LOT) and the strongly convex-regularized OT, which includes the well-known entropy-regularized OT (EROT). Experiments show the effectiveness of our algorithms for LOT and EROT in synthetic/real-world data that has a strict/approximate cyclic symmetry structure. Through theoretical and experimental results, this paper successfully introduces the concept of symmetry into the OT research field for the first time

Study on the Transport Characteristics of Floating Garbage in Hori River

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Controlling extraordinary transmission characteristics of metal hole arrays with spoof surface plasmons

We experimentally controlled the spectral characteristics of the extraordinary transmissions observed in metal hole arrays by analogy with spoof surface plasmon-polaritons (spoof SPPs), We constructed doubly periodic metal hole arrays. The larger and smaller periodic holes are for inducing extraordinary transmissions and modifying the spoof SPPs characteristics, respectively. Introducing the smaller holes that surround the larger hole arrays can modify the dispersion curve of the surface waves excited on a structured metal surface analogous to the spoof SPP model, and consequently, the extraordinary transmission peak will show a redshift. (C) 2012 American Institute of Physics. [https://doi.org/10.1063/1.3689784]ArticleAPPLIED PHYSICS LETTERS. 100(8):081112 (2012)journal articl

HNF-1β過剰発現を呈する卵巣明細胞癌においてGSK-3βは新たなシグナル伝達経路を介在する

Deubiquitinase USP28 is a target gene of the transcription factor HNF1 homeobox β (HNF-1β), which promotes the survival of ovarian clear cell carcinoma (OCCC) cell lines. However, the pharmacological inhibition of HNF-1β can cause several adverse effects as it is abundantly expressed in numerous organ systems, including the kidney, liver, pancreas and digestive tract. Therefore, small interfering RNA (siRNA) screening was performed in the current study to identify other potential downstream targets of the HNF-1β-mediated pathway. The results revealed that glycogen synthase kinase-3β (GSK-3β) may be a potential downstream target affecting cell viability. To further clarify the effects of GSK-3β, two human OCCC cell lines, TOV-21G (HNF-1β overexpressing line) and ES2 (HNF-1β negative) were transfected with siRNA targeting GSK-3β or control vectors. Loss-of-function studies using RNAi-mediated gene silencing indicated that HNF-1β facilitated GSK-3β expression, resulting in the loss of phosphorylated nuclear factor-κB (p-NFκB) and the reduction of TOV-21G cell proliferation. The cell proliferation assay also revealed that GSK-3β inhibitors rescued the effects of HNF-1β silencing on cell viability in a dose-dependent manner. Furthermore, the GSK-3β inhibitor, AR-A014418, effectively inhibited tumor cell proliferation in a xenograft mouse model. In conclusion and to the best of our knowledge, the current study was the first to determine that GSK-3β is a target gene of HNF-1β. In addition, the results of the present study revealed the novel HNF-1β-GSK-3β-p-NFκB pathway, occurring in response to DNA damage. Targeting this pathway may therefore represent a putative, novel, anticancer strategy in patients with OCCC.博士（医学）・甲第785号・令和3年3月15日Copyright: © Kawaharaet al. This is an open access article distributed under theterms of CreativeCommons Attribution License(https://creativecommons.org/licenses/by-nc-nd/4.0/)