Three-Dimensional Turbulent Structure in Open Channel with Side-Overflow

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

人工種苗生産されたキジハタ仔稚魚の遊泳・摂餌関連形質の発達

人工種苗生産されたキジハタ仔稚魚について、遊泳と摂餌に関する形質の発育を記載し発育段階の設定を行った。遊泳では以下の5段階に分けられた：1）遊泳未発達期（D0～1）－遊泳に関する形質は出現しない時期；2）浮遊および胸鰭発達期（D2～9）－肩帯の構成要素が出現する時期；3）尾鰭推進準備期（D10－12～15－17）－脊索末端の上屈が開始・完了する時期；4）尾鰭＋体全体推進期（D15－17～20－22）－脊椎要素が出現・完成し、臀鰭と腹鰭、尾鰭の鰭条が定数になる時期；5）遊泳機能完成期（D20－22～）－稚魚としての遊泳能力が獲得される時期。摂餌でも以下の5段階に分けられた：1）摂餌未発達期（D0～2）－未開口で内部栄養に依存する時期；2）初期吸込み期（D3～9）－口腔を形成する要素が出現し、開口したことで陰圧を利用した摂餌が可能となる時期；3）吸込み摂餌期（D10－12～20－22）－口腔を形成する要素の化骨により吸込み機能が強化され、上顎に占める前上顎骨の長さが一定になることで口の開閉能力が増す時期；4）吸込み＋噛みつき期（D20－22～35）－摂餌関連形質はすべて出現・完成し、顎歯だけでなく前鋤骨歯や口蓋骨歯も出現する時期；5）摂餌機能完成期（D35～）－稚魚としての摂餌能力が獲得される時期。本研究の結果から、本種の初期飼育の困難さの一因が、内部栄養から外部栄養に切り替わる期間の遊泳・摂餌関連形質の発育の遅さであることが判明した。さらにD30を過ぎると、群れを形成するとともに、共食いの萌芽行動である「J字」ポーズが見られた。本研究の結果は、今後の本種をふくむハタ科魚類の種苗生産の新しい管理手法の開発に資すると期待される。Based on the development of swimming- and feeding-related characters, ontogenetic intervals of larvae and juveniles were investigated for hatchery-reared red spotted grouper, Epinephelus akaara. Five phases each were recognized for the development of swimming and feeding functions as follows. Swimming: 1) the phase with less active swimming (hatching to 1 day after hatching, D1); 2) the phase with body control by pectoral fins (D2～D9); 3) the phase with preparation of caudal fin propulsion (D10-12～D15-17); 4) the phase with caudal fin and whole body propulsion (D15-17～D20-22); 5) the phase of juvenile swimming mode (beyond D20-22). Feeding: 1) the phase with endogenous nutrient (hatching to D2); 2) the phase with initial feeding of sucking (D3～D9); 3) the phase with sucking ability increasing (D10-12～D20-22); 4) the phase with sucking and initial biting (D20-22～D35); 5) the phase of juvenile feeding mode (beyond D35). The present study revealed that the difficulties of larval rearing of the species would be partly due to the delay of development of characters related to swimming- and feeding-functions during the changeover from endogenous to exogenous feeding. After D30, the juveniles with functional swimming- and feeding-mode showed both swimming in schools and posing with “J-posture”, the latter being considered to be the onset of cannibalistic behavior. The results of present study are expected to contribute to the improvement of larval rearing system in groupers.今井 智・小金隆之・山下貴示: 国立研究開発法人水産研究・教育機構瀬戸内海区水産研究所資源生産部Satoshi IMAI, Takayuki KOGANE, Takashi YAMASHITA: Stock Enhancement and Aquaculture Department, National Research Institute of Fisheries and Environment of Inland Sea, Fisheries Research and Education Agency河野 博: 東京海洋大学学術研究院海洋環境科学部門 魚類学研究室Hiroshi KOHNO: Laboratory of Ichthyology, Department of Ocean Sciences, Tokyo University of Marine Science and Technology (TUMSAT

Effect of pressure on single-chain magnets with repeating units of the MnIII-NiII-MnIII trimer

The single-chain magnet (SCM) system [Mn2(saltmen)2Ni(pao)2(L)2](A)2 (L: intrachain attaching ligand of NiII ion; A-1: interchain counteranion) is a ferromagnetic one-dimensional network system with repeating units of the MnIII-NiII-MnIII trimer which itself behaves as a single-molecule magnet with an S=3 spin ground state and negative uniaxial single-ion anisotropy (D) parallel to the bridging direction. The slow relaxation of the magnetic moment in this SCM system originates in an energy barrier for spin reversal (ΔE), which is closely related to the ferromagnetic interaction between the trimers (Jtrimer) as well as to the D of the trimer. We have investigated the effects of pressure on three compounds representative of the above SCM family through ac susceptibility measurements under hydrostatic pressures up to P=13.5 kbar and crystal structural analysis experiments up to P=20.0 kbar, and have observed a pronounced enlargement of ΔE when J was artificially increased. The application of hydrostatic pressure brought about the systematic enhancement of EΔ (a maximum increase of 10% within the pressure region of the experiments). The pressure dependence of EΔ varied according to the kind of attaching ligand L involved and the intrachain structure, and we have experimentally found that isotropic lattice shrinkage is desirable if a continuous increase of ΔE in this system is aimed at

Cerebral amyloid angiopathy-related inflammation presenting with steroid-responsive higher brain dysfunction: case report and review of the literature

A 56-year-old man noticed discomfort in his left lower limb, followed by convulsion and numbness in the same area. Magnetic resonance imaging (MRI) showed white matter lesions in the right parietal lobe accompanied by leptomeningeal or leptomeningeal and cortical post-contrast enhancement along the parietal sulci. The patient also exhibited higher brain dysfunction corresponding with the lesions on MRI. Histological pathology disclosed β-amyloid in the blood vessels and perivascular inflammation, which highlights the diagnosis of cerebral amyloid angiopathy (CAA)-related inflammation. Pulse steroid therapy was so effective that clinical and radiological findings immediately improved

Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior

Goal-directed behavior involves distributed neuronal circuits in the mammalian brain, including diverse regions of neocortex. However, the cellular basis of long-range cortico-cortical signaling during goal-directed behavior is poorly understood. Here, we recorded membrane potential of excitatory layer 2/3 pyramidal neurons in primary somatosensory barrel cortex (S1) projecting to either primary motor cortex (M1) or secondary somatosensory cortex (S2) during a whisker detection task, in which thirsty mice learn to lick for water reward in response to a whisker deflection. Whisker stimulation in 'Good performer' mice, but not 'Naive' mice, evoked long-lasting biphasic depolarization correlated with task performance in S2-projecting (S2-p) neurons, but not M1-projecting (M1-p) neurons. Furthermore, S2-p neurons, but not M1-p neurons, became excited during spontaneous unrewarded licking in 'Good performer' mice, but not in 'Naive' mice. Thus, a learning-induced, projection-specific signal from S1 to S2 may contribute to goal-directed sensorimotor transformation of whisker sensation into licking motor output

Biomarkers for Immune Checkpoint Inhibitors in Melanoma

Immune checkpoint inhibitors have now become a standard therapy for malignant melanoma. However, as immunotherapies are effective in only a limited number of patients, biomarker development remains one of the most important clinical challenges. Biomarkers predicting clinical benefit facilitate appropriate selection of individualized treatments for patients and maximize clinical benefits. Many biomarkers derived from tumors and peripheral blood components have recently been reported, mainly in retrospective settings. This review summarizes the recent findings of biomarker studies for predicting the clinical benefits of immunotherapies in melanoma patients. Taking into account the complex interactions between the immune system and various cancers, it would be difficult for only one biomarker to predict clinical benefits in all patients. Many efforts to discover candidate biomarkers are currently ongoing. In the future, verification, by means of a prospective study, may allow some of these candidates to be combined into a scoring system based on bioinformatics technology

Evaluation of Preoperative Magnetic Resonance Cholangiopancreatography in Acute Cholecystitis to Predict Technical Difficulties in Laparoscopic Cholecystectomy

Magnetic resonance cholangiopancreatography (MRCP) is a non-invasive imaging technique that provides high-quality visualization of the biliary tree, including the gallbladder. This study aimed to evaluate the useful-ness of preoperative MRCP for acute cholecystitis in predicting technical difficulties during laparoscopic chole-cystectomy (LC). A total of 168 patients who underwent LC with preoperative MRCP were enrolled in this study. Patients were divided into two groups according to preoperative MRCP findings: the visualized group (n = 126), in which the entire gallbladder could be visualized; and the non-visualized group (n = 42), in which the entire gallbladder could not be visualized. The perioperative characteristics and postoperative complica-tions of the two groups were retrospectively analyzed. Operation time was longer in the non-visualized group (median 101.5 vs. 143.5 min; p < 0.001). The non-visualized group had significantly more intraoperative blood loss than the visualized group (median 5 vs. 10 g; p = 0.05). The rate of conversion to open cholecystectomy was significantly higher in the non-visualized group (1.6 vs. 9.5%; p = 0.03). In conclusion, patients in the non- visualized group showed higher difficulty in performance of LC. Our MRCP-based classification is a simple and effective means of predicting difficulties in performing LC for acute cholecystitis