Reduced glycemic variability and flexible graft function after islet transplantation: A case report

To date, studies of patients with islet transplantation addressing intermittently scanned continuous glucose monitoring profile and the flexibility of the graft islet function under different doses of insulin administration, both of which reflect the real daily life of patients, are quite limited. Here, we report a case of a 46‐year‐old woman who received islet transplantation after kidney transplantation. The patient was followed up over a period of 2 years after initial islet transplantation. Our results show that intermittently scanned continuous glucose monitoring can be useful for monitoring the reduction of glycemic variability, and suggest the appropriate regulation of insulin secretion from graft islets during mixed‐meal test by using different doses of exogenous insulin administration. Additionally, during the 2‐year observational period, glucagon elevation was detected only at hypoglycemia, whereas the level was within the normal range at normoglycemia or hyperglycemia

ADH Responses to Thoracic and Abdominal Surgery under Epidural Anesthesia

Changes of plasma ADH concentration were studied during thoracic and abdominal operations under epidural anesthesia comnbimed with nitrous oxide inhalation. In abdominal surgeries, ADH level was elevated by operative invasion as usually reported, significantly by peritoneal irritation particularly. In thoracic surgeries, on the other hand, ADH level showed a rise by operative invasion, but little significant change was observed by irritation to the pleura. There was no significant difference in ADH level between the high frequency positive-pressure ventilation group and the intermittent positive-pressure ventilation group

Changes in Serum Granulocyte Colony-Stimulating Factor Concentration after Gastrointestinal Surgery

Granulocyte colony-sitmulating factor (G-CSF ; normal range < 30 pg/ml) is a cytokine that stimulates the proliferation and activation of neutrophils. In this study, we investigated changes in the plasma G-CSF level after gastrointestinal surgery. The subjects were 23 patients undergoing subtotal esophagectomy (Group E, n = 8), pancreaticoduodenectomy (Group P, n = 5), radical total gastrectomy (Group G, n = 5), or cholecystectomy (Group C, n = 5). In addition to G-CSF, duration of surgery, transfused fluid volume, C-reactive protein (CRP) concentration and neutrophil counts were recorded. G-CSF levels just after surgery were 3,301±2,130 pg/ml (mean ±SD), 1,442±180 pg/ml, 941 ±538 pg/ml, and 111±73pg/ml for patients in proups E, P, G and C, respectively. G-CSF levels were correlated with postoperative maximum CRP, the duration of surgery and the transfused fluid volume during the operation. The results show that extensive surgical procedures are associated with higher postoperative plasma G-CSF levels, suggesting that the increase in plasma G-CSF may be due to activation of the host defense in response to surgical stress

Three-dimensional electronic structure in ferromagnetic Fe3Sn2\textrm{Fe}_3\textrm{Sn}_2 with breathing kagome bilayers

A large anomalous Hall effect (AHE) has been observed in ferromagnetic $\textrm{Fe}_3\textrm{Sn}_2$ with breathing kagome bilayers. To understand the underlying mechanism for this, we investigate the electronic structure of $\textrm{Fe}_3\textrm{Sn}_2$ by angle-resolved photoemission spectroscopy (ARPES). In particular, we use both vacuum ultraviolet light (VUV) and soft x ray (SX), which allow surface-sensitive and relatively bulk-sensitive measurements, respectively, and distinguish bulk states from surface states, which should be unlikely related to the AHE. While VUV-ARPES observes two-dimensional bands mostly due to surface states, SX-ARPES reveals three-dimensional band dispersions with a periodicity of the rhombohedral unit cell in the bulk. Our data show a good consistency with a theoretical calculation based on density functional theory, suggesting a possibility that $\textrm{Fe}_3\textrm{Sn}_2$ is a magnetic Weyl semimetal.Comment: 6 pages, 4 figure

Postoperative Coagulation Changes in Patients with esophageal carcinoma

Postoperative coagulation changes were studied in 50 patients with esophageal carcinomas for 7 days following operation. Of these, 12 patients were examined further for changes in platelet aggregation rate as an index of platelet function. Just after operation, both platelet count and aggregation rate decreased, but at day 2 when the platelet count reached its lowest point, platelet aggregation returned to the preoperative level. Altough platelet aggregation decreased again, it recovered to the preoperative level earlier than did the platelet count. Changes in prothrombin time, activated partial thromboplastin time and fibrinogen and FDP-E levels may suggest pre-DIC state

Effects of Histamine Receptor Blockers and the Rate of Administration of Morphine on Cardiovascular System

Blood pressure reduction during the high dose morphine anesthesia was investigated from the point of view of histamine receptor blockers and the rate of morphine administration. It was found as the results that blood pressure reduction was prevented by the administration of the histamine receptor blockers, and the effect was almost equivalent to that caused by morphine with the rate of infusion at 2 mg/min. Safer anesthesia may be performed in term of blood pressure reduction when H1 and H2 receptor blockers and a slow infusion of morphine with small divided doses are given