Holographic Geometry of cMERA for Quantum Quenches and Finite Temperature

We study the time evolution of cMERA (continuous MERA) under quantum quenches in free field theories. We calculate the corresponding holographic metric using the proposal of arXiv:1208.3469 and confirm that it qualitatively agrees with its gravity dual given by a half of the AdS black hole spacetime, argued by Hartman and Maldacena in arXiv:1303.1080. By doubling the cMERA for the quantum quench, we give an explicit construction of finite temperature cMERA. We also study cMERA in the presence of chemical potential and show that there is an enhancement of metric in the infrared region corresponding to the Fermi energy.Comment: 33 pages, 8 figures. v2: typos corrected, references adde

Dynamics of Entanglement Entropy from Einstein Equation

We study the dynamics of entanglement entropy for weakly excited states in conformal field theories by using the AdS/CFT. This is aimed at a first step to find a counterpart of Einstein equation in the CFT language. In particular, we point out that the entanglement entropy satisfies differential equations which directly correspond to the Einstein equation in several setups of AdS/CFT. We also define a quantity called entanglement density in higher dimensional field theories and study its dynamical property for weakly excited states in conformal field theories.Comment: v2: 24 pages, calculations of translationally invariant limit have been corrected in section 4 and 5. References adde

Paclitaxel-Based Chemotherapy for Advanced Pancreatic Cancer after Gemcitabine-Based Therapy Failure: A Case Series of 5 Patients

Background/Objectives: Gemcitabine (GEM) is a gold-standard chemotherapy agent for advanced pancreatic cancer. Because of the malignant character of the disease, nearly all patients show disease progression despite treatment with GEM-based chemotherapy; therefore, second-line chemotherapy may be beneficial for these patients. We report a retrospective analysis of 5 patients with advanced pancreatic cancer, treated with a paclitaxel-containing regimen as second-, third- or fourth-line chemotherapy after various therapies, such as a GEM-based regimen, S-1 regimen, and chemoradiation. We retrospectively analyzed the efficacy and adverse events, and evaluated the paclitaxel-containing regimens. A review of the literature is also discussed. Results: The median overall survival from the start of salvage therapy was 10.7 months. The disease control rate of the paclitaxel-containing regimen according to RECIST criteria was 60%, including complete response in 0 patients, partial response in 3, and stable disease in 2. Two patients had malignant ascites at the start of this salvage therapy, and in both of them the ascites and clinical complaints improved. Grade 3 and 4 hematological adverse events were observed in 2 patients and 1 patient, respectively. Conclusion: Salvage paclitaxel-based therapy could be beneficial to advanced pancreatic cancer patients who maintain good performance status after several chemotherapy failures

Effects of 16-Week Consumption of Caffeinated and Decaffeinated Instant Coffee on Glucose Metabolism in a Randomized Controlled Trial

Objective. Observational studies have shown a protective association between coffee consumption and type 2 diabetes mellitus whereas caffeine or caffeinated coffee acutely deteriorates glucose tolerance. We investigated the effects of chronic drinking of instant coffee on glucose and insulin concentrations during a 75 g oral glucose tolerance test. Methods. Overweight men with a mild-to-moderate elevation of fasting plasma glucose were randomly allocated to a 16-week intervention of consuming 5 cups of caffeinated (n=17) or decaffeinated (n=15) instant coffee per day or no coffee (n=13). Results. The caffeinated coffee group showed statistically significant decreases in the 2-hour concentrations and the area under the curve of glucose while neither decaffeinated coffee nor coffee group showed such a change. Waist circumstance decreased in the caffeinated coffee group, increased in the decaffeinated coffee group, and did not change in the noncoffee group (P=0.002). With adjustment for the change in waist circumference, caffeinated and decaffeinated coffee consumption were associated with a modest decrease in the postload glucose levels. Conclusion. Both caffeinated and decaffeinated coffee may be protective against deterioration of glucose tolerance

Experiments on Fine-Particle Plasmas for Observation of Critical Phenomena

Abstract The particle-motion temperature in a two-dimensional structure was estimated from the time evolution of the speed of a fine particle to be around 0.1 eV with an accuracy of less than 0.1 eV. It was observed that fine particles were isotropically arranged in a planar magnetron plasma, which diffused upward, in three dimensions, without the formation of a void