図書館情報学とアーカイブズ学 : 九州大学ライブラリーサイエンス専攻に期待する

１． 九州大学における「ライブラリー・サイエンス」の構成 / ２． 実証科学としての図書館情報学とアーカイブズ学 / ３．情報管理の高度化プロセス / ４．アーカイブズ学の内容構成 / ５． アーカイブズの将来平成22年12月18日(土)に九州大学中央図書館 新館４階視聴覚ホールにて開催された、ライブラリーサイエンス専攻設置記念シンポジウムでの発表資料

図書館情報学とアーカイブズ学 : 九州大学ライブラリーサイエンス専攻に期待する

１． 九州大学における「ライブラリー・サイエンス」の構成 / ２． 実証科学としての図書館情報学とアーカイブズ学 / ３．情報管理の高度化プロセス / ４．アーカイブズ学の内容構成 / ５． アーカイブズの将来平成22年12月18日(土)に九州大学中央図書館 新館４階視聴覚ホールにて開催された、ライブラリーサイエンス専攻設置記念シンポジウムでの発表資料

Asymmetric Synthesis of beta-Lactams through Copper-Catalyzed Alkyne-Nitrone Coupling with a Prolinol-Phosphine Chiral Ligand

Prolinol-phosphine chiral ligands enabled highly enantioselective copper-catalyzed intermolecular alkyne-nitrone coupling (Kinugasa reaction) to produce 1,3,4-trisubstituted chiral beta-lactams. A high level of enantiocontrol was achieved not only with aryl-or alkenylacetylenes but also with alkylacetylenes, which were important but unfavorable substrates in the previously reported protocols. Two-point hydrogen bonding between the chiral ligand and the nitrone oxyanion consisting of O-H center dot center dot center dot O and C(sp(3)) H center dot center dot center dot O hydrogen bonds is proposed

A case of bone metastasis of colon cancer that markedly responded to S-1/CPT-11 combination chemotherapy and became curable by resection

Abstract Background An oral combined fluoropyrimidine anticancer drug, tegafur/gimeracil/oteracil potassium (S-1), has recently been used alone or in combination for colon cancer. Case presentation The patient was a 42-year-old man with sigmoid colon cancer with direct invasion of the urinary bladder and multiple costal metastases. A diagnosis of T4, M1, stage IV sigmoid colon cancer was made, and curative resection was considered impossible. S-1 at 50 mg/m2 was administered by oral route from day 1 to day 14. Irinotecan (CPT-11) at 40 mg/m2 was administered by intravenous day 1 and 15. This treatment was followed by 2 weeks absent period, and repeated every 4 weeks. Six cycles of administration were performed in total. Following this treatment, the multiple costal metastases resolved. Down-staging to T3, M0, stage IIA was achieved, and curative resection was judged to be possible. Conclusion Occasional cases in which S-1/CPT-11 therapy was effective have been recently reported. The patient's tumor became resectable despite the discovery of colon cancer associated with bone metastasis at the initial examination, offering hope for cancer patients.</p