ヒストンアセチル化リーダータンパク質ATAD2の分解を介した低酸素がん細胞の化学療法抵抗性獲得機構

京都大学新制・課程博士博士(医学)甲第24801号医博第4993号新制||医||1067(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 鈴木 実, 教授 溝脇 尚志, 教授 江木 盛時学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

Lung metastasis of ta bladder cancer: a case report and literature review.

A 66-year-old man with a history of multiple transurethral resections for recurrent bladder tumors, staged as Ta according to the International Union Against Cancer staging guidelines, presented with a complaint of dry cough. A round nodule with a diameter of 7.5 cm was detected in the lung by chest computed tomography, and a video-assisted thoracoscopic lobectomy was performed. Pulmonary metastasis of recurrent bladder cancer was diagnosed by immunohistochemistry staining for the urothelium-specific protein uroplakin Ia. Subsequently, 2 cycles of systemic chemotherapy were administered. Two and a half years after treatment, no recurrence of pulmonary lesions has been detected. A combination of complete resection of pulmonary lesions and systemic chemotherapy may result in a good prognosis for patients with non-muscle-invasive bladder cancer