Selective induction hyperthermia following transcatheter arterial embolization with a mixture of nano sized magnetic particles (Ferucarbotran ) and embolic materials: feasibility study in rabbits

取得学位 : 博士（医学）, 学位授与番号 : 医博甲第1932号 , 学位授与年月日 : 平成20年3月22日, 学位授与大学 : 金沢大学, 主査教授 : 太田 哲生, 副査教授 : 渡邊 剛 , 山岸 正

Effect of daily setup errors on individual dose distribution in conventional radiotherapy: An initial study

金沢大学医薬保健研究域保健学系Recent linear accelerators can perform cone-beam computed tomography to correct setup errors immediately before dose delivery. We calculated the dose distribution with setup errors acquired from cone-beam computed tomography to determine a more realistic and individual effect of setup errors. The differences in dose distribution were analyzed. The setup errors of three patients who were irradiated in the neck, esophagus, and pelvic area were obtained retrospectively. We found that the maximum dose variances for the three cases were 19.9-35.9%. The maximum dose variance points were relatively far from the isocenter. The volume of the 10% dose difference had widths of 1.3-1.85 cm around the beam edges. The V95 and mean doses at the clinical target volume were mostly unchanged. Doses around the beam edges were more varied than those around the isocenter for every case. The dose on the spinal cord located near the beam edges varied by 5-10% compared with the dose of the radiotherapy plan in two of the cases. We demonstrated the individual dose distributions of the cases affected by daily setup errors for all fractions. © 2009 Japanese Society of Radiological Technology and Japan Society of Medical Physics

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

The mobilization of hematopoietic stem cells does not require osteoclasts, which may even have an inhibitory effect

陽子線治療後肝癌の画像変化と治療効果判定方法の研究

本研究では、陽子線治療後肝細胞癌の血行動態の変化を時系列で追跡し、再発肝細胞癌に特徴的な経時的変化と、その血行動態を明らかにすることを目的として、陽子線治療後肝細胞癌とその周囲肝実質の変化について、CTやMRI画像を用いて解析した。　陽子線治療によって肝細胞癌の血行動態に変化が生じ、かつ陽子線照射を受けた周囲肝実質においても限局的な放射線肝炎を生じ血行動態に変化が生じる。再発肝癌についてはこれらの治療後変化とは異なる特徴的な血行動態の変化を経時的に追うことはできなかったが、再発肝癌自体は通常の古典的肝癌と同じく、動脈相での早期濃染所見を呈することが示唆された。The purpose of the study was to evaluate the changes of diagnostic imaging findings of hepatocellular carcinoma (HCC) after proton beam therapy (PBT) and to analyze the evaluation method of the treatment effect after PBT for HCC. HCCs lost the characteristic of arterial enhancement after PBT, and surrounding liver tissue irradiated by PBT caused a focal radiation hepatitis. The regrown HCC after PBT acquired the arterial enhancement again. This finding may assist the early diagnosis of recurrent HCC after PBT.研究課題/領域番号:16K10273, 研究期間(年度):2016-04-01 - 2019-03-3