Ultrastrong tunable coupler between superconducting LC resonators

We investigate the ultrastrong tunable coupler for coupling of superconducting resonators. Obtained coupling constant exceeds 1 GHz, and the wide range tunability is achieved both antiferromagnetics and ferromagnetics from $-1086$ MHz to 604 MHz. The ultrastrong coupler is composed of rf-SQUID and dc-SQUID as tunable junctions, which connected to resonators via shared aluminum thin film meander lines enabling such a huge coupling constant. The spectrum of the coupler obviously shows the breaking of the rotating wave approximation, and our circuit model treating the Josephson junction as a tunable inductance reproduces the experimental results well. The ultrastrong coupler is expected to be utilized in quantum annealing circuits and/or NISQ devices with dense connections between qubits.Comment: 12pages, 7 figure

Comet 9P/Tempel 1: Interpretation with the Deep Impact Results

According to our common understandings, the original surface of a short-period comet nucleus has been lost by sublimation processes during its close approaches to the Sun. Sublimation results in the formation of a dust mantle on the retreated surface and in chemical differentiation of ices over tens or hundreds of meters below the mantle. In the course of NASA's Deep Impact mission, optical and infrared imaging observations of the ejecta plume were conducted by several researchers, but their interpretations of the data came as a big surprise: (1) The nucleus of comet 9P/Tempel 1 is free of a dust mantle, but maintains its pristine crust of submicron-sized carbonaceous grains; (2) Primordial materials are accessible already at a depth of several tens of cm with abundant silicate grains of submicrometer sizes. In this study, we demonstrate that a standard model of cometary nuclei explains well available observational data: (1) A dust mantle with a thickness of ~1-2 m builds up on the surface, where compact aggregates larger than tens of micrometers dominate; (2) Large fluffy aggregates are embedded in chemically differentiated layers as well as in the deepest part of the nucleus with primordial materials. We conclude that the Deep Impact results do not need any peculiar view of a comet nucleus.Comment: 11 pages, 1 figure, 1 table. ApJ letters, 673, L199-20

Generation of third-harmonic spin oscillation from strong spin precession induced by terahertz magnetic near fields

The ability to drive a spin system to state far from the equilibrium is indispensable for investigating spin structures of antiferromagnets and their functional nonlinearities for spintronics. While optical methods have been considered for spin excitation, terahertz (THz) pulses appear to be a more convenient means of direct spin excitation without requiring coupling between spins and orbitals or phonons. However, room-temperature responses are usually limited to small deviations from the equilibrium state because of the relatively weak THz magnetic fields in common approaches. Here, we studied the magnetization dynamics in a HoFeO3 crystal at room temperature. A custom-made spiral-shaped microstructure was used to locally generate a strong multicycle THz magnetic near field perpendicular to the crystal surface; the maximum magnetic field amplitude of about 2 T was achieved. The observed time-resolved change in the Faraday ellipticity clearly showed second- and third-order harmonics of the magnetization oscillation and an asymmetric oscillation behaviour. Not only the ferromagnetic vector M but also the antiferromagnetic vector L plays an important role in the nonlinear dynamics of spin systems far from equilibrium

Experimental evidence of a strong image force between highly charged electrosprayed molecular ions and a metal screen

We investigated the capturing mechanisms of highly charged macromolecular ions of polyethylene glycol electrosprayed onto a metal screen. Our experiments assessed how the charge state, size of the macromolecular ions, and filtration velocity affected the penetration of the ions through the metal screen. The single fiber efficiencies were plotted as functions of the Peclet number and image force parameter. Highly charged molecular ions had much higher collection efficiencies than neutralized macromolecules, suggesting the presence of a strong image force between the ions and metal surface. The single fiber efficiency by image force was proportional to the square root of an image force parameter predicted by theory. When using the prefactor of 9.7 proposed by Alonso et al. (2007), we found fair agreement between the experimental data and theoretical predictions on the collection efficiency of highly charged molecular ions with mobility diameters from 2.6 to 4.8 nm and numbers of electrical charges from 2 to 7. The experimental evidence from our study reveals that image force contributes strongly to the collection of multicharged macromolecular ions by a metal wire screen. © Taiwan Association for Aerosol Research

Hormonal Therapy Resistant Estrogen-receptor Positive Metastatic Breast Cancer Cohort (HORSE-BC) Study : Current Status of Treatment Selection in Japan

The Hormonal therapy resistant estrogen-receptor positive metastatic breast cancer cohort (HORSE-BC) study is a multicenter observational study evaluating the efficacy and safety of secondary endocrine therapy (ET) for postmenopausal cases of metastatic breast cancer (MBC) with poor response to primary ET. In this initial report we analyze the HORSE-BC baseline data to clarify the current status of treatment selection for MBC in Japan. Baseline data for the 50 patients enrolled in HORSE-BC were analyzed, including patient characteristics, types of secondary ET, and reasons for selecting secondary ET. Postoperative recurrence was detected in 84% of patients (42/50) and de novo stage IV breast cancer in 16% (8/50). Forty-one patients (41/50; 82%) received fulvestrant, 5 patients (10%) received selective estrogen receptor modulators (SERMs), 3 patients (6%) received ET plus a mammalian target of rapamycin (mTOR) inhibitor, and 1 patient received an aromatase inhibitor (AI) as the secondary ET. Forty-five patients selected their secondary ET based on its therapeutic effect, while 14 patients selected it based on side effects. Most patients with progression after primary ET selected fulvestrant as the secondary ET based on its therapeutic and side effects. We await the final results from the HORSE-BC study

Prospective cohort study of febrile neutropenia in breast cancer patients administered with neoadjuvant and adjuvant chemotherapies: CSPOR-BC FN study

Background As Asians are more vulnerable to febrile neutropenia (FN) than Caucasians, evaluations of FN incidence and risk factors in Asians are important for the appropriate use of primary pegfilgrastim (PEG-G). Patients and methods Japanese breast cancer patients receiving standard adjuvant chemotherapies were prospectively enrolled in multicenter institutions from August 2015 to July 2017. FN was evaluated from 2 treatment policies: true FN (T-FN): ≥37.5 °C, grade 4 neutropenia, mandatory hospital visit (visiting); surrogate FN (S-FN): ≥37.5 °C, oral antibiotic, no mandatory visit (non-visiting). PEG-G was used at the physicians’ discretion. The primary endpoint was FN incidence during all cycles. Multivariate logistic regression analysis was performed to identify T-FN risk factors. Results Of 1005 enrolled patients, 980 women treated with FEC, E(A)C, and TC were analyzed. The FN incidence proportions in all patients were 22.5%, 27.5%, and 33.9% for FEC, E(A)C, and TC, respectively. Those of T-FN were 27.7%, 22.4%, and 36.6%; those of S-FN were 17.3%, 32.4%, and 31.5% with more frequent primary PEG-G usage. The relative dose intensity (RDI) of the 3 regimens was ≥0.85 in both groups. In the analysis of risk factors, TC (odds ratio = 2.67), age ≥ 65 years (2.24), and pretreatment absolute neutrophil count (ANC)/1000 μl (0.8) remained significant. Conclusions FN incidences were above 20% in the 3 regimens, with TC showing the highest. RDI was maintained at a high level in both visiting and non-visiting groups. Patient-related risk factors were age and pretreatment ANC

Astrodynamics Science About Itokawa, Gravity and Ephemeris

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76347/1/AIAA-2006-6658-569.pd

Clinical Statistics for Dysphagia Patients ≦ 18 Years of Age in the Center of Special Needs Dentistry, April 2012-March 2013

In April 2012, the Center of Special Needs Dentistry (SND) was established at Showa University Dental Hospital to provide function training for children with eating and swallowing disorders. A statistical clinical assessment was performed on new patients ≤18 years of age who visited the Center over a 1-year period (April 2012–March 2013) to assess the conditions present at the initial visit. In all, 60 patients (29 boys, 31 girls, mean (± SD) age 4.2±4.1 years, range 0-18 years of age) were included in the study. Most patients were <1 year of age (32%) and most came from one of four cities in the Johnan area (Shinagawa City, Meguro City, Ota City and Setagaya City). The most common primary diseases at the initial visit were cerebral palsy and cleft lip and palate. The third largest patient group was of healthy children with oral function problem. Over 60% of patients attended the Center of SND because of an eating-related complaint. More than 50% of patients were obtaining nutrients via oral intake; the remaining patients were obtaining nutrients via non-oral or a combination of oral and non-oral intake. Because of the young age of the patients and the fact that most were from neighboring areas, it can be inferred that effective community health care is being provided. It is necessary for the Center of SND to continue to provide professional treatment for dysphagia and to contribute to community medicine