Agent for preventing and ameliorating aging of skin

PROBLEM TO BE SOLVED: To obtain the subject new cosmetic by compounding a phosphorylated polysaccharide having humectant action and collagen-producing performance as an active component. SOLUTION: This cosmetic contains a compound of the formula (Glc is glucose residue; Gal is galactose residue; Rha is rhamnose residue; (m) is 0-3; (n) is 1,000-5,000) as an active component. The component of the formula can be produced by hydrolyzing actinase E of defatted milk, treating the defatted milk with ultrafiltration membrane, sterilizing the filtrate to obtain a culture medium, aseptically pipetting the sterilized medium into a jar fermenter, inoculating a precultured liquid, culturing at 20 deg.C and pH5.5 using NH3 water as a neutralizing agent, subjecting the cultured product to centrifugal separation after culture to recover the supernatant, adding an equal amount of CH3 OH, recovering the produced precipitate, dissolving the precipitate in 0.2N saline water, repeating the precipitation operation with CH3 OH, subjecting the treated precipitate to electrophoresis, recovering the component impregnated into the gel and purifying the recovered fraction by ion-exchange chromatography to obtain purified polysaccharide. It is necessary to compound a cosmetic with &gt;=0.001wt.% of the compound of the formula.</p

Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case report

A female patient in her 50 s was found to have a 10-cm tumor resulting from locally advanced cervical cancer (LACC). Three-year relapse-free survival was achieved following a multimodal treatment strategy integrating chemoradiotherapy (CRT), regional hyperthermia (RHT), and interstitial brachytherapy (ISBT). Given the large size of the tumor, enhancement of the geometrical dose distribution was anticipated using ISBT. However, delivery of a sufficient dose to the high-risk clinical target volume was predicted to be challenging. Thus, RHT was incorporated to potentially augment the overall treatment effect. This unique combination of CRT, RHT and ISBT may be promising for management of large LACC and warrants further investigation