αシヌクレインのBACトランスジェニックマウスはレム睡眠行動異常症様の症状および嗅覚低下を呈し、パーキンソン病前駆期モデルとなる

京都大学新制・課程博士博士(医学)甲第23089号医博第4716号新制||医||1050(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 高橋 淳, 教授 浅野 雅秀, 教授 伊佐 正学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

Near-Infrared Spectroscopy of the Cool Brown Dwarf, SDSS 1624+00

Using the Subaru Telescope, we have obtained multiple near-infrared spectra of the cool brown dwarf, SDSS 1624+00, in search of spectral variability in an 80 minute time span. We have found the suspected variability of water vapor absorption throughout the observations, which requires confirmation by a longer time baseline. After coadding the spectra, we have obtained a high-quality spectrum covering 1.05 to 1.8 um. Three kinds of spectral indicators, the water vapor bands, methane band, and KI lines in J band, suggest that SDSS 1624+00 is warmer and dustier than Gl 229B.Comment: 6 figures, to appear in PAS

Superwind-Driven Intense H_2 Emission in NGC 6240

We have performed a long-slit K band spectroscopic observation of the luminous infrared galaxy NGC 6240. The peak position of the H_2 v=1-0 S(1) emission in the slit is located ~0.3" - 0.4" north of the southern nucleus. It is almost the midpoint between the southern nucleus and the peak position of the ^12CO J=1-0 emission. Based on the line-ratio analyses, we suggest the excitation mechanism of H_2 is pure thermal at most positions. In the southern region we find the following three velocity components in the H_2 emission: the blueshifted shell component (~-250 km s^-1 with respect to V_sys) which is recognized as a distinct C-shape distortion in the velocity field around the southern nucleus, the high-velocity blueshifted ``wing'' component (~-1000 km s^-1 with respect to V_sys), and the component indicating possible line splitting of ~500 km s^-1. The latter two components are extended to the south from the southern nucleus. We show that the kinematic properties of these three components can be reproduced by expanding motion of a shell-like structure around the southern nucleus. The offset peak position of the H_2 emission can be understood if we assume that the shell expanding to the north interacts with the extragalactic molecular gas. At the interface between the shell and the molecular gas concentration the cloud-crushing mechanism proposed by Cowie et al. (1981) may work efficiently, and the intense H_2 emission is thus expected there. All these findings lead us to propose a model that the most H_2 emission is attributed to the shock excitation driven by the superwind activity of the southern nucleus.Comment: 33 pages, 9 figures, accepted for publication in PAS

Infrared Imaging of z=2.43 Radio Galaxy B3 0731+438 with the Subaru Telescope - Detection of Hα\alpha Ionization Cones of a Powerful Radio Galaxy

We report on infrared imaging observations of the z=2.429 radio galaxy B3 0731+438 with the Subaru telescope. The images were taken with the K'-band filter and the 2.25 um narrow-band filter to examine the structure and properties of the Ha+[N II] 6548,6583 emission-line components. The Ha+[N II] emission-line image shows biconical lobes with an extent of 40 kpc, which are aligned with the radio axis. The rest-frame equivalent widths of the emission lines at these cones are as large as 1100 AA, and can be well explained by a gas-cloud model photoionized by power-law continuum radiation. The isotropic ionizing photon luminosity necessary to ionize the hydrogen gas in these cones amounts to 1e57(photons/s), which is larger than that in the majority of radio-loud QSOs. From these results, we propose that the Ha alignment effect in this object is produced by biconical gas clouds, which are swept up by the passage of radio jets, and are ionized by strong UV radiation from a hidden AGN. The continuum image consists of two components, a stellar-like point source and an extended diffuse galaxy. These are supposed to be a type-2 AGN and its host galaxy. The SED is fitted by a combination of spectra of a reddened dust-scattered AGN and an instantaneous starburst population of 500 Myr old. The stellar mass of the galaxy is estimated to be 3e11 M_solar, which is as large as that of typical 3C radio galaxies at z=1.Comment: 12 pages, 4 Postscript figures, uses PASJ2.sty, PASJ95.sty, PASJadd.sty. Accepted for publication in PASJ (2000

Perampanel Inhibits α‐Synuclein Transmission in Parkinson's Disease Models

パーキンソン病モデルへのペランパネルの有効性を確認 --パーキンソン病の進行抑制治療への期待--. 京都大学プレスリリース. 2021-04-05.[Background]: The intercellular transmission of pathogenic proteins plays a key role in the clinicopathological progression of neurodegenerative diseases. Previous studies have demonstrated that this uptake and release process is regulated by neuronal activity. [Objective]: The objective of this study was to examine the effect of perampanel, an antiepileptic drug, on α‐synuclein transmission in cultured cells and mouse models of Parkinson's disease.Methods: Mouse primary hippocampal neurons were transduced with α‐synuclein preformed fibrils to examine the effect of perampanel on the development of α‐synuclein pathology and its mechanisms of action. An α‐synuclein preformed fibril‐injected mouse model was used to validate the effect of oral administration of perampanel on the α‐synuclein pathology in vivo. [Results]: Perampanel inhibited the development of α‐synuclein pathology in mouse hippocampal neurons transduced with α‐synuclein preformed fibrils. Interestingly, perampanel blocked the neuronal uptake of α‐synuclein preformed fibrils by inhibiting macropinocytosis in a neuronal activity‐dependent manner. We confirmed that oral administration of perampanel ameliorated the development of α‐synuclein pathology in wild‐type mice inoculated with α‐synuclein preformed fibrils.[Conclusion]: Modulation of neuronal activity could be a promising therapeutic target for Parkinson's disease, and perampanel could be a novel disease‐modifying drug for Parkinson's disease

Subaru Observations for the K-band Luminosity Distribution of Galaxies in Clusters near to 3C 324 at z∼\sim1.2

We investigate the $K$-band luminosity distribution of galaxies in the region of clusters at $z\sim1.2$ near to the radio galaxy 3C 324. The imaging data were obtained during the commissioning period of the Subaru telescope. There is a significant excess of the surface number density of the galaxies with $K =$ 17--20 mag in the region within $\sim$ 40'' from 3C 324. At this bright end, the measured luminosity distribution shows a drop, which can be represented by the exponential cut off of the Schechter-function formula; the best-fitted value of the characteristic magnitude, $K^{*}$, is $\sim 18.4\pm0.8$. This measurement follows the evolutionary trend of the $K^*$ of the rich clusters observed at an intermediate redshift, which is consistent with passive evolution models with a formation redshift z_f \gtsim 2. At K \gtsim 20 mag, however, the excess of the galaxy surface density in the region of the clusters decreases abruptly, which may imply that the luminosity function of the cluster galaxies has a negative slope at the faint end. This may imply strong luminosity segregation between the inner and outer parts of the clusters, or some deficit of faint galaxies in the cluster central region of the cluster.Comment: 12 pages, 9 figures, accepted for publication in PAS

High-Resolution Near-Infrared Imaging of the Powerful Radio Galaxy 3C 324 at z = 1.21 with the Subaru Telescope

We have obtained high-resolution K'-band images of the powerful z=1.206 radio galaxy 3C 324 with the Subaru telescope under seeing conditions of 0.3--0.4 arcsec. We clearly resolved the galaxy and directly compared it to the optical images obtained with the Hubble Space Telescope. The host galaxy of 3C 324 is revealed to be a moderately luminous elliptical galaxy with a smooth light profile. The effective radius of the galaxy, as determined by profile fitting, is 1.3+-0.1 arcsec (1.2 kpc), which is significantly smaller than the value of 2.2 arcsec, published in Best et al. (1998, MNRAS, 292, 758). The peak of the K'-band light coincides with the position of the radio core, which implies that the powerful AGN lies at the nucleus of the host galaxy. The peak also coincides with the gap in the optical knotty structures which may be a dust lane hiding the UV-optical emission of the AGN from our line of sight; it is very likely that we are seeing the obscuring structure almost edge-on. We clearly detected the `aligned component' in the K'-band image by subtracting a model elliptical galaxy from the observed image. The red R_F702W-K color of the outer region of the galaxy avoiding the aligned component indicates that the near infrared light of the host galaxy is dominated by an old stellar population.Comment: 21 pages (10 figures), accepted for publication in PAS