Hybrid superconducting quantum magnetometer

A superconducting quantum magnetometer based on magnetic flux-driven modulation of the density of states of a proximized metallic nanowire is theoretically analyzed. With optimized geometrical and material parameters transfer functions up to a few mV/Phi_0 and intrinsic flux noise ~10^{-9}Phi_0 Hz^{-1/2} below 1 K are achievable. The opportunity to access single-spin detection joined with limited dissipation (of the order of ~ 10^{-14} W) make this magnetometer interesting for the investigation of the switching dynamics of molecules or individual magnetic nanoparticles.Comment: 6 pages, 6 color figures, added calculation of the Josephson current, published versio

Nonequilibrium spin-dependent phenomena in mesoscopic superconductor-normal metal tunnel structures

We analyze the broad range of spin-dependent nonequilibrium transport properties of hybrid systems composed of a normal region tunnel coupled to two superconductors with exchange fields induced by the proximity to thin ferromagnetic layers and highlight its functionalities. By calculating the quasiparticle distribution functions in the normal region we find that they are spin-dependent and strongly sensitive to the relative angle between exchange fields in the two superconductors. The impact of inelastic collisions on their properties is addressed. As a result, the electric current flowing through the system is found to be strongly dependent on the relative angle between exchange fields, giving rise to a huge value of magnetoresistance. Moreover, the current presents a complete spin-polarization in a wide range of bias voltages, even in the quasiequilibrium case. In the nonequilibrium limit we parametrize the distributions with an ``effective`` temperature, which turns out to be strongly spin-dependent, though quite sensitive to inelastic collisions. By tunnel coupling the normal region to an additional superconducting electrode we show that it is possible to implement a spin-polarized current source of both spin species, depending on the bias voltages applied.Comment: Published version: 12 pages, 14 figures; new text added and one figure modifie

Interactions between sympathetic nervous system and endogenous endothelin in patients with essential hypertension

Experimental evidence indicates that endothelin 1 stimulates the sympathetic nervous system by activation of the subtype A receptor. The aim of the present study was to assess whether this mechanism is active in humans and to investigate its potential role in the pathogenesis of essential hypertension. In 15 hypertensive patients and 12 normotensive subjects, blood pressure, heart rate, and muscle sympathetic nerve activity were evaluated during intravenous 20-minute infusion of BQ123 (0.1 mg/kg per hour), an endothelin A receptor antagonist, and sodium nitroprusside (SNP; 0.4 μg/kg per minute). In hypertensive patients, blood pressure was reduced similarly by BQ123 and SNP. In contrast, the increase in muscle sympathetic nerve activity induced by BQ123 (from 52.0±4.9 to 56.8±5.5 bursts per 100 heartbeats; P<0.05 versus baseline) was significantly lower (P<0.05) than that induced by SNP (from 50.6±4.9 to 61.1±5.1 bursts per 100 heartbeats; P<0.05 versus baseline). In normotensive subjects, SNP reduced blood pressure and increased muscle sympathetic activity, whereas BQ123 was ineffective. Thus, in a subgroup (n=9) of normotensive subjects, we administered BQ123 at a higher dose (0.2 mg/kg per hour), representing an equidepressor dose of SNP, inducing a blunted increase in sympathetic activity (from 44.1±2.4 to 50.1±6.4 bursts per 100 heartbeats; P<0.05 versus baseline). Finally, administration of a different vasodilator (papaverine, 0.5 mg/kg per hour) exerted results superimposable to SNP. Endogenous endothelin 1 appears to have a sympathoexcitatory effect both in normotensive and hypertensive subjects through endothelin A receptors, contributing to basal sympathetic vasomotor tone. Moreover, essential hypertension shows an increased susceptibility to the sympathoexcitatory effect of endogenous endothelin 1