139 research outputs found
Effects of gender and aging in patients who undergo coronary artery bypass grafting: From the FU-Registry
Background: It is unclear whether gender and aging influence the characteristics of patients
who undergo coronary artery bypass grafting (CABG).
Methods: We retrospectively reviewed a clinical database of 1,498 patients (male/female = 1133/365, age 67 ± 9 years) who underwent CABG at Fukuoka University Hospital from
1994 to 2010.
Results: Male showed significantly younger, higher percentages (%) of smoking and
hyperuricemia (HU), higher levels of serum creatinine, and lower % hypertension (HT) and
diabetes mellitus (DM), and lower levels of left ventricular ejection fraction than female. In
multivariate analysis, all parameters identified independent variables associated with the
gender difference. Next, we divided the patients into 5 groups according to age, and each group
was then separated by gender. The % of males significantly decreased with aging, whereas
% female significantly increased. Although % smoking and estimated glomerular filtration rate
(eGFR), and body mass index (BMI) in all patients, males and females significantly decreased
with aging, HU, left ventricular end diastolic pressure and the number of significantly stenosed
coronary vessels were not associated with gender or aging. Interestingly, % HT in all patients
and males significantly increased with aging, whereas that in females was not associated with
aging. Serum low-density lipoprotein cholesterol levels in males significantly decreased with
aging, while those in all patients and females were not associated with aging. In this
contemporary data set, the decreases in % smoking and eGFR with aging were common
characteristics in male and female patients. In addition, there were gender and aging differences
in % smoking, % HT, BMI and eGFR, whereas no differences were observed in % DM, % dyslipidemia
or % HU.
Conclusions: Before CABG, high-risk patients with coronary artery disease who is going to
undergo CABG may need to be managed more strictly considering to gender and age to avoid
CABG
Distinct morphologic, phenotypic, and clinical-course characteristics of indolent peripheral T-cell lymphoma
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) consists of a heterogeneous group of lymphomas. Patients. generally show an aggressive clinical course and very poor outcome. Although the 2008 World Health Organization classification of PTCL-NOS includes 3 variants, low-grade lymphoma is not Included. Of 277 PTCL-NOS cases recorded in our consultation files, we examined the clinicopathologic characteristics of 10 patients with T-cell lymphomas composed of small-sized cells with slight nuclear atypia. Eight patients showed extranodal involvement (5 patients, spleen; 3 patients, thyroid), and 5 patients were at clinical stage I or II. Histologically, all samples presented diffuse infiltrate of small lymphoid cells, with few mitotic figures. Immunohistologically, all samples were positive for CD3, and CD:20 Was detected in 5 samples. All samples showed a low Ki-67 labeling index (mean, 1.05%), and 7 samples were positive for central memory T-cell markers. Clonal T-cell receptor gamma chain and/or alpha-beta chain gene rearrangements were detected in all 10 patients. Five patients received chemotherapy, whereas for 3 patients, treatment consisted only of observation following surgical resection of the spleen or thyroid. Nine patients were alive at a median follow-up time of 19.5 months, whereas 1 patient died of an unrelated disease. The present study strongly indicates that T-cell lymphoma with small-sized lymphoma cells and a low Ki-67 labeling index is a distinct variant. Recognition of this novel lymphoma subtype, which should not be defined merely as PTCL-NOS, should be seriously considered
The Japanese space gravitational wave antenna; DECIGO
DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future
Japanese space gravitational wave antenna. DECIGO is expected to open a new window of
observation for gravitational wave astronomy especially between 0.1 Hz and 10 Hz, revealing
various mysteries of the universe such as dark energy, formation mechanism of supermassive
black holes, and inflation of the universe. The pre-conceptual design of DECIGO consists of
three drag-free spacecraft, whose relative displacements are measured by a differential Fabry–
Perot Michelson interferometer. We plan to launch two missions, DECIGO pathfinder and pre-
DECIGO first and finally DECIGO in 2024
DECIGO pathfinder
DECIGO pathfinder (DPF) is a milestone satellite mission for DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) which is a future space gravitational wave antenna. DECIGO is expected to provide us fruitful insights into the universe, in particular about dark energy, a formation mechanism of supermassive black holes, and the inflation of the universe. Since DECIGO will be an extremely large mission which will formed by three drag-free spacecraft with 1000m separation, it is significant to gain the technical feasibility of DECIGO before its planned launch in 2024. Thus, we are planning to launch two milestone missions: DPF and pre-DECIGO. The conceptual design and current status of the first milestone mission, DPF, are reviewed in this article
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