35 research outputs found
Reconciling Neutralino Relic Density with Yukawa Unified Supersymmetric Models
Supersymmetric grand unified models based on the gauge group SO(10) are
especially attractive in light of recent data on neutrino masses. The simplest
SO(10) SUSY GUT models predict unification of third generation Yukawa couplings
in addition to the usual gauge coupling unification. Recent surveys of Yukawa
unified SUSY GUT models predict an inverted scalar mass hierarchy in the
spectrum of sparticle masses if the superpotential mu term is positive. In
general, such models tend to predict an overabundance of dark matter in the
universe. We survey several solutions to the dark matter problem in Yukawa
unified supersymmetric models. One solution-- lowering the GUT scale mass value
of first and second generation scalars-- leads to u_R and c_R squark masses in
the 90-120 GeV regime, which should be accessible to Fermilab Tevatron
experiments. We also examine relaxing gaugino mass universality which may solve
the relic density problem by having neutralino annihilations via the Z or h
resonances, or by having a wino-like LSP.Comment: 21 page file plus 9 figures; updated version to coincide with
published versio
The Reach of the Fermilab Tevatron and CERN LHC for Gaugino Mediated SUSY Breaking Models
In supersymmetric models with gaugino mediated SUSY breaking (inoMSB), it is
assumed that SUSY breaking on a hidden brane is communicated to the visible
brane via gauge superfields which propagate in the bulk. This leads to GUT
models where the common gaugino mass is the only soft SUSY breaking
term to receive contributions at tree level. To obtain a viable phenomenology,
it is assumed that the gaugino mass is induced at some scale beyond the
GUT scale, and that additional renormalization group running takes place
between and as in a SUSY GUT. We assume an SU(5) SUSY GUT above
the GUT scale, and compute the SUSY particle spectrum expected in models with
inoMSB. We use the Monte Carlo program ISAJET to simulate signals within the
inoMSB model, and compute the SUSY reach including cuts and triggers approriate
to Fermilab Tevatron and CERN LHC experiments. We find no reach for SUSY by the
Tevatron collider in the trilepton channel. %either with or without %identified
tau leptons. At the CERN LHC, values of (1160) GeV can be probed
with 10 (100) fb of integrated luminosity, corresponding to a reach in
terms of of 2150 (2500) GeV. The inoMSB model and mSUGRA can likely
only be differentiated at a linear collider with sufficient energy to
produce sleptons and charginos.Comment: 17 page revtex file with 9 PS figure
Reach of the Fermilab Tevatron for minimal supergravity in the region of large scalar masses
The reach of the Fermilab Tevatron for supersymmetric matter has been
calculated in the framework of the minimal supergravity model in the clean
trilepton channel. Previous analyses of this channel were restricted to scalar
masses m_0<= 1 TeV. We extend the analysis to large values of scalar masses
m_0\sim 3.5 TeV. This includes the compelling hyperbolic branch/focus point
(HB/FP) region, where the superpotential \mu parameter becomes small. In this
region, assuming a 5\sigma (3\sigma) signal with 10 (25) fb^{-1} of integrated
luminosity, the Tevatron reach in the trilepton channel extends up to
m_{1/2}\sim 190 (270) GeV independent of \tan\beta . This corresponds to a
reach in terms of the gluino mass of m_{\tg}\sim 575 (750) GeV.Comment: 11 page latex file including 6 EPS figures; several typos corrected
and references adde
Exploring the BWCA (Bino-Wino Co-Annihilation) Scenario for Neutralino Dark Matter
In supersymmetric models with non-universal gaugino masses, it is possible to
have opposite-sign SU(2) and U(1) gaugino mass terms. In these models, the
gaugino eigenstates experience little mixing so that the lightest SUSY particle
remains either pure bino or pure wino. The neutralino relic density can only be
brought into accord with the WMAP measured value when bino-wino co-annihilation
(BWCA) acts to enhance the dark matter annihilation rate. We map out parameter
space regions and mass spectra which are characteristic of the BWCA scenario.
Direct and indirect dark matter detection rates are shown to be typically very
low. At collider experiments, the BWCA scenario is typified by a small mass gap
m_{\tilde Z_2}-m_{\tilde Z_1} ~ 20-80 GeV, so that tree level two body decays
of \tilde Z_2 are not allowed. However, in this case the second lightest
neutralino has an enhanced loop decay branching fraction to photons. While the
photonic neutralino decay signature looks difficult to extract at the Fermilab
Tevatron, it should lead to distinctive events at the CERN LHC and at a linear
e^+e^- collider.Comment: 44 pages, 21 figure
Updated Reach of the CERN LHC and Constraints from Relic Density, b->s gamma and a(mu) in the mSUGRA Model
{We present an updated assessment of the reach of the CERN LHC pp collider
for supersymmetric matter in the context of the minimal supergravity (mSUGRA)
model. In addition to previously examined channels, we also include signals
with an isolated photon or with a leptonically decaying Z boson. For an
integrated luminosity of 100 fb^{-1}, values of m_{1/2}\sim 1400 GeV can be
probed for small m_0, corresponding to a gluino mass of m_{\tg}\sim 3 TeV. For
large m_0, in the hyperbolic branch/focus point region, m_{1/2}\sim 700 GeV can
be probed, corresponding to m_{\tg}\sim 1800 GeV. We also map out parameter
space regions preferred by the measured values of the dark matter relic
density, the b\to s\gamma decay rate, and the muon anomalous magnetic moment
a_\mu, and discuss how SUSY might reveal itself in these regions. We find the
CERN LHC can probe the entire stau co-annihilation region and also most of the
heavy Higgs annihilation funnel allowed by WMAP data, except for some range of
large m_0 and m_{1/2} if \tan\beta \agt 50.Comment: 22 page latex file including 10 EPS figures; bug fix in relic density
code modifies figures in co-annihilation regio
Combined QCM-D/GE as a tool to characterize stimuli-responsive swelling of and protein adsorption on polymer brushes grafted onto 3D-nanostructures
East European reforms and developing countries trade prospects: A medium term perspective
Ultrafast magnetic scattering on ferrimagnets enabled by a bright Yb-based soft x-ray source
Development of ultrafast table-top x-ray sources that can map various spin, orbital, and electronic configurations and reordering processes on their natural time and length scales is an essential topic for modern condensed matter physics as well as ultrafast science. In this work, we demonstrate spatiotemporally resolved resonant magnetic scattering (XRMS) to probe the inner-shell 4d electrons of a rare-earth (RE) composite ferrimagnetic system using a bright >200eV soft x-ray high harmonic generation (HHG) source, which is relevant for future energy-efficient, high-speed spintronic applications. The XRMS is enabled by direct driving of the HHG process with power-scalable, high-energy Yb laser technology. The optimally phase-matched broadband plateau of the HHG offers a record photon flux (>2×109photons/s/1% bandwidth) with excellent spatial coherence and covers the entire resonant energy range of RE’s N4,5 edges. We verify the underlying physics of our x-ray generation strategy through the analysis of microscopic and macroscopic processes. Using a CoTb alloy as a prototypical ferrimagnetic system, we retrieve the spin dynamics, and resolve a fast demagnetization time of 500±126fs, concomitant with an expansion of the domain periodicity, corresponding to a domain wall velocity of ∼750m/s. The results confirm that, far from cross-contamination of low-energy absorption edges in multi-element systems, the highly localized states of 4d electrons associated with the N4,5 edges can provide high-quality core-level magnetic information on par with what can be obtained at the M edges, which is currently accessible only at large-scale x-ray facilities. The analysis also indicates the rich material-, composition-, and probing-energy-dependent driving mechanism of RE-associated multicomponent systems. Considering the rapid emergence of high-power Yb lasers combined with novel nonlinear compression technology, this work indicates potential for next-generation high-performance soft x-ray HHG-based sources in future extremely photon-hungry applications on the table-top scale, such as probing electronic motion in biologically relevant molecules in their physiological environment (liquid phase), and advanced coherent imaging of nano-engineered devices with 5∼8nm resolution
The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis
Currently, there are no effective therapies for patients with triple-negative breast cancer (TNBC), an aggressive and highly metastatic disease. Activation of eukaryotic initiation factor 4E (eIF4E) by mitogen-activated protein kinase (MAPK)-interacting kinases 1 and 2 (Mnk1/2) play a critical role in the development, progression and metastasis of TNBC. Herein, we undertook a comprehensive study to evaluate the activity of a first-in-class Mnk1/2 protein degraders, racemic VNLG-152R and its two enantiomers (VNLG-152E1 and VNLG-152E2) in in vitro and in vivo models of TNBC. These studies enabled us to identify racemic VNLG-152R as the most efficacious Mnk1/2 degrader, superior to its pure enantiomers. By targeting Mnk1/2 protein degradation (activity), VNLG-152R potently inhibited both Mnk-eIF4E and mTORC1 signaling pathways and strongly regulated downstream factors involved in cell cycle regulation, apoptosis, pro-inflammatory cytokines/chemokines secretion, epithelial-mesenchymal transition (EMT) and metastasis. Most importantly, orally bioavailable VNLG-152R exhibited remarkable antitumor (91 to 100% growth inhibition) and antimetastatic (~80% inhibition) activities against cell line and patient-derived TNBC xenograft models, with no apparent host toxicity. Collectively, these studies demonstrate that targeting Mnk-eIF4E/mTORC1 signaling with a potent Mnk1/2 degrader, VNLG-152R, is a novel therapeutic strategy that can be developed as monotherapy for the effective treatment of patients with primary/metastatic TNBC