Oxidative addition of RCO2H and HX to chiral diphosphine complexes of iridium(I): convenient synthesis of mononuclear halo-carboxylate-iridium(III) complexes and cationic dinuclear triply-halogen-bridged iridium(III) complexes and their catalytic performance in asymmetric hydrogenation of cyclic imines and 2-phenylquinoline

International audienc

Oxidative addition of RCO2H and HX to chiral diphosphine complexes of iridium(I): convenient synthesis of mononuclear halo-carboxylate-iridium(III) complexes and cationic dinuclear triply-halogen-bridged iridium(III) complexes and their catalytic performance in asymmetric hydrogenation of cyclic imines and 2-phenylquinoline

International audienc

Adventure in Asymmetric Hydrogenation: Synthesis of Chiral Phosphorus Ligands and Asymmetric Hydrogenation of Heteroaromatics

Catalytic asymmetric hydrogenations of prochiral unsaturated compounds, such as olefins, ketones, and imines, have been intensively studied and are considered as a versatile method of the synthesis of chiral compounds due to atom economy and operational simplicity. Since 2002, we mainly focused on synthesis of new phosphorus ligands, asymmetric hydrogenation of heteroaromatic compounds and palladium-catalyzed asymmetric hydrogenation. Significant contribution was made in the Dalian Institute of Chemical Physics. In this chapter, we hope to share our experience and adventure in the development of chiral monophosphite ligands and phosphine phosphoramidite ligands, asymmetric hydrogenation of heteroaromatic compounds, and the development of new homogeneous palladium catalytic hydrogenation system, which have a wide range of applications in synthesis of chiral compounds