The role of IL-1 gene polymorphisms (IL1A, IL1B, and IL1RN) as a risk factor in unsuccessful implants retaining overdentures

Purpose: Implant-supported overdentures are an alternative predictable rehabilitation method that has a high impact on improving the patient's quality of life. However, some biological complications may interfere with the maintenance and survival of these overdenture implants. The goal of this article was to assess the factors that affect periimplant success, through a hypothetical prediction model for biological complications of implant overdentures.Methods: A retrospective observational, prevalence study was conducted in 58 edentulous Caucasian patients rehabilitated with implant overdentures. A total of 229 implants were included in the study. Anamnestic, clinical, and implant-related parameters were collected and recorded in a single database. "Patient" was chosen as the unit of analysis, and a complete screening protocol was established. The data analytical study included assessing the odds ratio, concerning the presence or absence of a particular risk factor, by using binary logistic regression modeling. Probability values (p values) inferior to 0.05 were considered as representing statistically significant evidence.Results: The performed prediction model included the following variables: mean probing depth, metal exposure, IL1B_allele2, maxillary edentulousness, and Fusobacterium nucleatum. The F. nucleatum showed significant association with the outcome. Introducing a negative coefficient appeared to prevent complications or even boost the biological defense when associated with other factors.Conclusions: The prediction model developed in this study could serve as a basis for further improved models that would assist clinicians in the daily diagnosis and treatment planning practice of oral rehabilitation with implant overdentures.info:eu-repo/semantics/publishedVersio

Pyridyl-amino acids for potential catalysts

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Miglioramento continuo della qualità degli eventi

Il progetto di monitoraggio del grado di soddisfazione degli utenti degli eventi organizzati dall’Istat è stato avviato a partire da settembre 2015 Il progetto si inserisce all’interno di un processo di miglioramento continuo della qualità degli eventi realizzati dall’Istituto, perseguito sia attraverso il monitoraggio continuo delle adesioni e delle presenze alle iniziative organizzate dall’Istituto, sia attraverso l’analisi delle valutazioni espresse dagli utenti in merito all’esperienza di fruizione

Aziridination of alpha,beta-unsaturated ketones

alpha,beta-Unsaturated ketones are aziridinated by [(arenesulphonyl)oxy]carbamates and CaO (or Cs2CO3) or by N3CO2Et photolysis. A remote chiral center induced up to 74% de. Bis-unsaturated substrates showed scarce regioselectivity under all conditions. (C) 1998 Elsevier Science Ltd. AII rights reserved

Strain-promoted reaction of 1,2,4-triazines with bicyclononynes

Strain-Promoted Inverse Electron Demand Diels-Alder Cycloaddition (SPIEDAC) reactions between 1,2,4,5-tetrazines and strained dienophiles such as bicyclononynes are among the fastest biorthogonal reactions. However the synthesis of 1,2,4,5-tetrazines is complex and can involve volatile reagents. 1,2,4-triazines also undergo cycloaddition reactions with acyclic and unstrained dienophiles at elevated temperatures but their reaction with strained alkynes has not been described. We postulated that 1,2,4-triazines would react with strained alkynes at low temperatures and therefore provide an alternative to the tetrazine-cycloaddition reaction for use in in vitro or in vivo labelling experiments. We describe the synthesis of a 1,2,4 triazin-3-ylalanine derivative fully compatible with the Fmoc strategy for peptide synthesis and demonstrate its reaction with strained bicyclononynes at 37 °C with rates comparable to the reaction of azides with the same substrates. The synthetic route to triazinylalanine is readily adaptable to late-stage functionalization of other probe molecules and the 1,2,4-triazine-SPIEDAC therefore has potential as an alternative to tetrazine-cycloaddition for applications in cellular and biochemical studies