HKCOG guidelines: induction of ovulation

This guideline by The Hong Kong College of Obstetricians and Gynaecologists (HKCOG) covers the classification of ovulation disorders, treatment options of various ovulation disorders, and their associated risks.published_or_final_versio

Live birth rate, multiple pregnancy rate, and obstetric outcomes of elective single and double embryo transfers: Hong Kong experience

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A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders

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Effect of letrozole on uterine artery Doppler flow indices prior to first-trimester termination of pregnancy : a randomized controlled trial

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Comparing the inter-cycle variation of serum anti-Mullerian hormone and antral follicle count measurements in predicting ovarian response before IVF

This journal suppl. entitled: Abstracts of the 32nd Annual Meeting of the European Society of Human Reproduction and EmbryologySTUDY QUESTION: Does serum anti-Mullerian hormone (AMH) have less intercycle variation than antral follicle count (AFC) when used as an ovarian response predictor? SUMMARY ANSWER: Inter-cycle variations were significantly less with serum AMH than AFC measurement, although both have no significant difference in their predictive performance on poor ovarian response. WHAT IS KNOWN ALREADY: Both AMH and AFC measurements are recognized as the best markers for predicting ovarian response before IVF treatment. There was one report in the European population indicating that AMH (measured using the older ELISA) had less inter-cycle variation than AFC. However, there is no report on this in the Asian population nor using the newer generation ELISA. STUDY DESIGN, SIZE, DURATION: This observational study was a secondary analysis using AMH and AFC data from control subjects of another prospective clinical trial on the effect of DHEA pre-treatment. Only control subjects (n = 45) in the placebo arm were included in this secondary analysis. AMH and AFC measurements over four consecutive menstrual cycles before they underwent standard IVF treatment using the GnRH antagonist protocol were analysed. PARTICIPANTS/MATERIALS, SETTING, METHODS: The subjects underwent IVF treatment in a university-affiliated hospital in Hong Kong. AFC was measured in the early follicular phase (between days 2–5) by transvaginal ultrasonography in four consecutive cycles, and serum was obtained on the same occasions for AMH measurement using the Gen II AMH ELISA (Beckman-Coulter). The intra-class correlation coefficients (ICC) for AFC and AMH across the four study cycles, as well as their predictive performance on poor ovarian response, were compared. MAIN RESULTS AND THE ROLE OF CHANCE: Subjects were aged between 30 and 40 years. No significant difference was observed in AFC (p = 0.114) and AMH (p = 0.375) across the four study cycles (Friedman’s test). The single-measures ICC of AFC and AMH were 0.597 (95% CI 0.459–0.726) and 0.850 (95% CI 0.778–0.906) respectively. The average-measures ICC of AFC were 0.856 (95% CI 0.773–0.914) and 0.958 (95% CI 0.933–0.975), respectively. Hence, both single-measures and average-measures ICC were significantly higher with AMH than with AFC. The areas under the ROC curve of the four AFC measurements in predicting poor ovarian response (defined as three or less oocytes retrieved) in the subsequent IVF cycle ranged from 0.693 (95% CI 0.536–0.844) to 0.818 (95% CI 0.672–0.918) with no significant difference (p > 0.05) between the four cycles, whereas those of the four AMH measurement ranged from 0.785 (95% CI 0.636–0.895) to 0.821 (95% CI 0.676–0.920) with no significant difference (p > 0.05) between the four cycles. LIMITATIONS, REASONS FOR CAUTION: This was a secondary analysis on data obtained from another clinical trial; no data on intra-cycle variation of AFC and AMH was available. WIDER IMPLICATIONS OF THE FINDINGS: Our study in the Chinese population using the newer generation AMH ELISA concurred with the findings from a previous European study. Although both AFC and AMH are good predictors of ovarian response, AMH is less subjected to inter-cycle variation than AFC, hence allowing pre-IVF assessment at more flexible timing

Rough implant surfaces suppress proliferation of mesenchymal stem cells and is associated with cell-cell contact

Conference Theme: Foot and Ankle Surgery - 足部及足踝外科N211 Concurrent Free Papers 4 – Basic Science/Rehabilitation: no. 4.

The Endocrine Disruptor Perflurooctane Sulfonate (PFOS) modulates spheroids attachment onto endometrial cells through Wnt/β -catenin Inhibition

Poster Presentation: Theme 2: Cancer & Cell Biology: no. 2.2

Effect of preovulatory progesterone elevation and duration of progesterone elevation on the pregnancy rate of frozen–thawed embryo transfer in natural cycles

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