9 research outputs found
Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)
- Author
- A Mitsui
- A Shilatifard
- Bernhard Ryffel
- BZ Carter
- C McCallum
- D Qiu
- DB Bregman
- FC Christians
- HM Sobell
- J Peng
- JA Hartley
- Jin-jian Lu
- JM Fidler
- JN Ratner
- JQ Svejstrup
- KB Lee
- Li He
- M Huang
- ME Kang
- MF Dubois
- MS Kobor
- N Inukai
- NF Marshall
- PA Phillips
- PL Olive
- PL Olive
- Qiang Yu
- S Vispe
- S Yang
- SD Westerheide
- SJ Leuenroth
- SJ Leuenroth
- SK Radhakrishnan
- T Efferth
- T Oelgeschlager
- TM Kiviharju
- TW Corson
- X Bao
- XH Jiang
- Y Jung
- Y Matsui
- Y Wang
- Y Wu
- Ying Wang
- YJ Choi
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Triptolide (TPL), a key biologically active component of the Chinese medicinal herb Tripterygium wilfordii Hook. f., has potent anti-inflammation and anti-cancer activities. Its anti-proliferative and pro-apoptotic effects have been reported to be related to the inhibition of Nuclear Factor κB (NF-κB) and Nuclear Factor of Activated T-cells (NFAT) mediated transcription and suppression of HSP70 expression. The direct targets and precise mechanisms that are responsible for the gene expression inhibition, however, remain unknown. Here, we report that TPL inhibits global gene transcription by inducing proteasome-dependent degradation of the largest subunit of RNA polymerase II (Rpb1) in cancer cells. In the presence of proteosome inhibitor MG132, TPL treatment causes hyperphosphorylation of Rpb1 by activation of upstream protein kinases such as Positive Transcription Elongation Factor b (P-TEFb) in a time and dose dependent manner. Also, we observe that short time incubation of TPL with cancer cells induces DNA damage. In conclusion, we propose a new mechanism of how TPL works in killing cancer. TPL inhibits global transcription in cancer cells by induction of phosphorylation and subsequent proteasome-dependent degradation of Rpb1 resulting in global gene transcription, which may explain the high potency of TPL in killing cancer
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
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- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
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- Y Bdolah
- Y Chen
- Y Christen
- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-Üstün
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
- Y Levites
- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Enhanced artemisinin yield by expression of rol genes in Artemisia annua
- Author
- A Dangash
- A Spena
- A Spena
- AB Sabater-Jara
- AC Altvorst Van
- B García-Sogo B
- BH Kiani
- Bushra Mirza
- C Maurel
- C Maurel
- D Chen
- E Casanova
- Erum Dilshad
- F Filippini
- F Filippini
- G Biswajit
- G Sa
- GD Brown
- I Ahmed
- J Palazon
- J Palazon
- Javier Palazon
- JF Ferreira
- JFS Ferreira
- JT Odell
- Karla Ramirez Estrada
- KH Teoh
- L Olofsson
- L Tao
- M Cardarelli
- M Cui
- M Lies
- M Zia
- ME Olsson
- Mercedes Bonfill
- MJ Towler
- MV Duke
- NJ White
- PE Duffy
- R Croteau
- Rosa Maria Cusido
- T Schmulling
- TE Wallaart
- TW Efferth
- VP Bulgakov
- VP Bulgakov
- W Arshad
- Y Zhang
- YN Shkryl
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Modulation of P-Glycoprotein-Mediated Multidrug Resistance by Synthetic and Phytochemical Small Molecules, Monoclonal Antibodies, and Therapeutic Nucleic Acids
- Author
- A Mahringer
- A Mahringer
- A Palmeira
- A Tamaki
- AB Shapiro
- AK Yang
- C Cordon-Cardo
- D Pal
- DM Woodcock
- E Pommerenke
- EW Pommerenke
- EW Pommerenke
- EW Pommerenke
- EW Pommerenke
- F Klepsch
- F Thiebaut
- G Kothandan
- G Kroemer
- G Stammler
- G Tonini
- H Inoue
- J Molnár
- JM Ford
- KM Pluchino
- L Amiri-Kordestani
- M Adams
- M Adams
- M Kober
- M Saeed
- M Volm
- M Volm
- M Volm
- M Volm
- M Volm
- M Volm
- M Volm
- M Volm
- O Kepp
- R Pirker
- RA Adams
- RF Ozols
- RJ Ferreira
- S Wöll
- SG Aller
- SM He
- T Bansal
- T Efferth
- T Efferth
- T Efferth
- T Efferth
- T Efferth
- T Eichhorn
- T Iwahashi
- T Nabekura
- TJ Curiel
- TL Truant
- TM Beer
- TW Loo
- TW Loo
- XD Qian
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Inhibition of ATP-Binding Cassette Transporters by Chinese Herbs and Phytochemicals
- Author
- A Angelini
- A Calcabrini
- A Goffeau
- A Gotoh
- A Johnsson
- A Mahringer
- A Ramu
- A Zhu
- AAB Bergen
- AH Schinkel
- AJ Smith
- AK Tiwari
- AM Bliek van der
- B Ebert
- B Vulevic
- B Łania-Pietrzak
- B Łania-Pietrzak
- BB Huang
- BI Sikic
- BJ Kuss
- BT Hill
- C Hirschmann-Jax
- C Wang
- CE Grant
- CF Higgins
- CF Higgins
- CF Higgins
- CH Choi
- CH Yang
- CJ Chen
- CK Wan
- CM Kruijtzer
- CP Wu
- CR Fairchild
- CY Yang
- D Patanasethanont
- D Steinbach
- D Xu
- DC Zhou
- DD Ross
- DF Zhu
- DM Zhang
- DW Loe
- DW Loe
- DW Loe
- E Girodon
- E Hopper-Borge
- E Nicolle
- EJ Wang
- F Farabegoli
- G Jedlitschky
- G Jedlitschky
- G Kelter
- G Liang
- G Yamano
- GD Kruh
- GG Wulf
- GH Li
- GJR Zaman
- H Herweijer
- H Naramoto
- H Nikaido
- H Shen
- H Suzuki
- H Tamaki
- H Zeng
- H Zeng
- HJ Yi
- HL Lin
- HL Lin
- HS You
- HW Yao
- HY Chen
- I Bieche
- I Leier
- IB Carr
- IB Roninson
- J Cao
- J Geng
- J Jing
- J Ma
- J Molnár
- J Tammur
- J Wang
- J Wijnholds
- J Zhang
- JB Vaidyanathan
- JB Vaidyanathan
- JC Fernandez-Checa
- JC Ruiz
- JD Allen
- JJ Smit
- JK Holland
- JM Ford
- JP Gillet
- JP Zhang
- JY Chang
- JY Dai
- JY Wu
- K Chan
- K Goda
- K Kobayashi
- K Koike
- K Lan
- K Miyake
- K Norwood
- K Takara
- K Taniguchi
- K Ueda
- K Yasui
- KA O’Leary
- KG Chen
- KH Choi
- L Fan
- L Fan
- L He
- L He
- L He
- L Li
- L Li
- LA Doyle
- LA Doyle
- LA Mickley
- LJ Goldstein
- LW Fu
- M Adams
- M Adams
- M Büchler
- M Dean
- M Heijn
- M Huang
- M Kool
- M Kool
- M Maliepaard
- M Minemura
- M Nakayama
- M Osmak
- M Sun
- M Volm
- M Volm
- MD Hall
- MD Sklar
- MG Belinsky
- MI Netsch
- MJ LeBlanc
- ML Holland
- ML Holland
- ML Slovak
- MM Gottesman
- MM Gottesman
- MR Baer
- N Gao
- N Nishimura
- N Zelcer
- NM Laing
- NY Frank
- P Abidi
- P Borst
- PH Leung
- PL Tsai
- PL Tsai
- PM Fracasso
- Q Tian
- Q Tian
- R Allikmets
- R Allikmets
- R Boonstra
- R Evers
- R Evers
- R Mayer
- R Mukai
- R Zhang
- RL Juliano
- RS Chapman
- S Childs
- S Childs
- S Fellner
- S Kawabata
- S Kitagawa
- S Majumder
- S Michaelis
- S Nobili
- S Park
- S Pratt
- S Ruetz
- S Scala
- S Yu
- S Zhang
- S Zhang
- S Zhang
- SE Bates
- SG Aller
- SH Lee
- SL Li
- SP Cole
- SP Cole
- SPC Cole
- SS Allen
- SS Zou
- SU Choi
- SW Wang
- T Bansal
- T Efferth
- T Efferth
- T Efferth
- T Efferth
- T Efferth
- T Efferth
- T Efferth
- T Efferth
- T Efferth
- T Efferth
- T Eichhorn
- T Gerloff
- T Hirohashi
- T Ishikawa
- T Ishikawa
- T Murakami
- T Nabekura
- T Oguri
- T Takahashi
- T Yokooji
- TH Tsai
- TJ Longhurst
- TK Bera
- TK Bera
- TP Schaub
- TW Loo
- TX Wang
- UK Walle
- V Fischer
- VK Wong
- VL Madgula
- VT Nguyen
- W Brand
- W Chearwae
- W Priebe
- W Qiu
- W Saurin
- W Wang
- WF Fong
- WF Fong
- WN Keith
- WS Dalton
- X Shen
- X Wang
- XB Wang
- XL Qin
- XW Yang
- XW Yang
- XY Yu
- XY Yu
- XY Yu
- XY Yu
- Y Arai
- Y Chen
- Y Chen
- Y Cui
- Y Dong
- Y Gu
- Y Guo
- Y Huang
- Y Huang
- Y Lee
- Y Li
- Y Mei
- Y Sadzuka
- YD Min
- YJ Hu
- YT Wu
- YW Chen
- ZS Chen
- ZW Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dihydroartemisinin prevents breast cancer-induced osteolysis via inhibiting both breast caner cells and osteoclasts
- Author
- A Kamalakar
- A Mariotti
- AE Mercer
- B Tian
- BK Park
- C Wang
- F Tremollieres
- GA Rodan
- GD Roodman
- GR Mundy
- GS Wu
- H Cao
- H Cao
- HH Chen
- HJ Kim
- J Hou
- JA Engelman
- JC Drooger
- JJ Body
- JJ Lu
- JJ Lu
- JP Hu
- KN Weilbaecher
- L Costa
- L Zhang
- LH Saal
- LJ Suva
- M Sayed
- M Shi
- M von Knoch
- MA Chellaiah
- N Kawamura
- NB Watts
- NJ White
- Q Ba
- RE Coleman
- RE Coleman
- RE Coleman
- S Casimiro
- S Kongpatanakul
- S Shrivastava
- SG Haskell
- T Efferth
- T Koga
- T Yoneda
- TA Guise
- TW Miller
- W Tan
- YP Hwang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
ATP Binding Cassette Transporters in Cancer Stem-Like Cells
- Author
- A Golebiewska
- A Gomez-Cabrero
- AC Hepburn
- AM Bleau
- B Lohberger
- BB Zhou
- BJ Wilson
- BP Sorrentino
- C Ginestier
- C Naujokat
- CJ Creighton
- CM Ghajar
- CW Scharenberg
- CY Lai
- D Bonnet
- D Fuchs
- D Fuchs
- DA Evseenko
- DP Freitas
- E Irollo
- EA McCulloch
- F Vesuna
- F Wang
- FF Huang
- G Bertolini
- G Ghiaur
- G Pirozzi
- GA Challen
- H Clevers
- H Li
- H Zhang
- J Chen
- J Maddox
- J Sims-Mourtada
- J Zhang
- J Zhou
- JE Visvader
- JE Visvader
- JI Fletcher
- JM Gerber
- JP Gillet
- JR Riordan
- K Morimoto
- KG Chen
- KG Chen
- KW Scotto
- L Armstrong
- L Gatti
- L Xiang
- LA Doyle
- M Al-Hajj
- M Chartrain
- M Czyz
- M Dean
- M Dean
- M Grimm
- M Kim
- M Perego
- M Raftopoulou
- M Saxena
- M Yang
- MA Goodell
- MA LaBarge
- MB Kastan
- MG Francipane
- MH Raaijmakers
- MO Islam
- MP McCormack
- MT Ma
- N Setia
- N Uchida
- NY Frank
- NY Frank
- P Borst
- P Dalerba
- P Liu
- P Mallini
- P Perego
- PB Gupta
- PP Liu
- Q Jia
- Q Niu
- R Bjerkvig
- R Januchowski
- R Padmanabhan
- RM Glasspool
- RR Singh
- S Gottschling
- S Ohtsuki
- S Pizzamiglio
- S Zhou
- S Zhou
- SA Mani
- SP Cole
- SV Ambudkar
- T Brabletz
- T Efferth
- T Ishikawa
- T Lapidot
- T Reya
- T Schatton
- T Tanei
- TW Loo
- V Alla
- V Hlavac
- V Martin
- V Saini
- V Tirino
- WJ Huss
- WJ Ingram
- WW Shen
- X Jiao
- X Li
- Y Imai
- YP Hu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
NRF2, cancer and calorie restriction
- Author
- A Banning
- A Bartke
- A Derjuga
- A Jemal
- A Kobayashi
- A Kobayashi
- A Kobayashi
- A Martín-Montalvo
- A Mitra
- A Muto
- A Singh
- A Tannenbaum
- A Tannenbaum
- AD Kraft
- AJ Butt
- AL Eggler
- AR Collins
- AT Dinkova-Kostova
- AT Dinkova-Kostova
- AT Dinkova-Kostova
- AY Shih
- AY Shih
- B Chandrasekar
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Onken
- B Padmanabhan
- BA Ruggeri
- BC Baguley
- BC Hansen
- BJ Willcox
- BT Hennessy
- C Chen
- C Gerhauser
- C Moreschi
- C Sell
- C Stack
- C Xu
- CC Udenigwe
- CD Klaassen
- CJ Henderson
- CK Lii
- CR Breese
- D Chartoumpekis
- D Kritchevsky
- D Kritchevsky
- D Palli
- D Pratico
- DA Bloom
- DD Zhang
- DF Birt
- DF Birt
- DF Birt
- DF Birt
- DF Birt
- DH Hyun
- DH Hyun
- DK Ingram
- DM Klurfeld
- DT Dexter
- E Giovannucci
- E Heiss
- E Lok
- E Marzetti
- E Warabi
- EC Miller
- EC Pietsch
- EJ Masoro
- EL Greer
- ER Stadtman
- F Fialka
- G Dai
- G Shen
- G Ye
- GA Boissonneault
- GB Gordon
- GP Sykiotis
- GR Thatcher
- H Lapillonne
- H Motohashi
- H Motohashi
- H Okawa
- H Wang
- H Warita
- H Yang
- HC Huang
- HH Lee
- HJ Thompson
- HM Brown-Borg
- I Shimokawa
- IA Volchegorskii
- J Cao
- J M Villalba
- J Maher
- J Reinhart
- JA Mattison
- JB Johnson
- JD Hayes
- JD Hayes
- JH Suh
- JJ Ramsey
- JK Campbell
- JL Weed
- JM Chan
- JM Lee
- JM Lee
- JM Lee
- JM Tullet
- JO Holloszy
- JR Cabral
- JW Chiao
- JW Fahey
- JW Stewart
- JY Chan
- JY Chan
- K Iida
- K Itoh
- K Itoh
- K Itoh
- K Kanninen
- KA Nolan
- KE Cheney
- KI Tong
- KI Tong
- KJ Davies
- KJ Jung
- KJ Pearson
- KK Andreou
- KV Williams
- KW Lee
- L Castello
- L Gross
- L Lagopoulos
- LA Wilson
- LL Pashko
- LL Pashko
- LM Aleksunes
- LM Shantz
- LV Favreau
- LW Wattenberg
- M Furukawa
- M Jimenez-Hidalgo
- M Kobayashi
- M Manjgaladze
- M McMahon
- M McMahon
- M McMahon
- M Muguruma
- M Patel
- M Philip
- M Pollak
- M Pollard
- M Ramos-Gomez
- M Ramos-Gomez
- M Shou
- M Suzuki
- M Xue
- M Zakkar
- MI Kang
- MJ Calkins
- MK Kwak
- MK Kwak
- MK Kwak
- MK Kwak
- ML Hyer
- MO Leonard
- MP Mattson
- MP Mattson
- MS Yates
- N Juge
- N Wakabayashi
- N Wakabayashi
- NA Bishop
- NC Burton
- ND Cohen
- NY Kalaany
- P Jenner
- P Moi
- P Navas
- P Nioi
- P Rous
- PH Shih
- PJ Shaw
- PS Fitzmaurice
- R Brigelius-Flohe
- R de Cabo
- R De Cabo
- R Garcea
- R Hu
- R Love
- R Mostoslavsky
- R Taub
- R Weindruch
- RJ Colman
- RJ Jakel
- RK Thimmulappa
- RS Friling
- RT Mulcahy
- S Braun
- S Kiritoshi
- S Lal
- S Mandlekar
- S Miyagi
- S Murakami
- S Nagaraj
- S Nair
- S Numazawa
- SB Cullinan
- SB Cullinan
- SD Hursting
- SD Hursting
- SH McKiernan
- SK Clinton
- SK Lee
- SS Ansher
- SS Hecht
- SY Bae
- T Efferth
- T Jiang
- T Nguyen
- T Nguyen
- T Oyake
- T Prestera
- T Rangasamy
- T Rangasamy
- T Shibata
- T Suzuki
- T Toki
- T Yamamoto
- TD Pugh
- TF Franke
- TH Howell
- TH Rushmore
- TO Khor
- TO Khor
- TV Nguyen
- TW Devling
- TW Kensler
- TW Kensler
- TW Kensler
- U auf dem Keller
- U Cakatay
- VK Halagappa
- W Duan
- W Qin
- WK Hong
- WO Osburn
- WR Fields
- WR Leifert
- WW Wasserman
- X Yu
- XL Chen
- XM Liu
- XZ Chang
- Y Aoki
- Y Ding
- Y Kitamura
- Y Li
- Y Zhang
- Z Djuric
- Z Guo
- Z Ungvari
- ZI Alam
- ZI Alam
- ZW Westerbeek
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sensitization to cell death induced by soluble Fas ligand and agonistic antibodies with exogenous agents: A review
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- Bergmann-Leitner ES Abrams SI
- Bergmann-Leitner ES Abrams SI
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- Biswas P Poli G, Orenstein JM, et al.
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2020
- Field of study