9 research outputs found
Global Implications of the Emergence of CommunityâAssociated MethicillinâResistant Staphylococcus aureus
Rhodobacter capsulatus magnesium chelatase subunit BchH contains an oxygen sensitive ironâsulfur cluster
Evaluation of effect of different solvent systems on functional and pharmacological properties of fruits and leaves extracts from natal plum
Impact of climate on the population dynamics of an alpine ungulate: a long-term study of the Tatra chamois Rupicapra rupicapra tatrica
Modelling Inborn Errors of Metabolism in Zebrafish
The majority of human inborn errors of metabolism are fatal multisystem disorders that lack proper treatment and have a poorly understood mechanistic basis. Novel technologies are required to address this issue, and the use of zebrafish to model these diseases is an emerging field. Here we present the published zebrafish models of inborn metabolic diseases, discuss their validity, and review the novel mechanistic insights that they have provided. We also review the available methods for creating and studying zebrafish disease models, advantages and disadvantages of using this model organism, and successful examples of the use of zebrafish for drug discovery and development. Using a zebrafish to model inborn errors of metabolism in vivo, although still in its infancy, shows promise for a deeper understanding of disease pathomechanisms, onset, and progression, and also for the development of specific therapies