Immunization of sheep against the larval stage of Taenia multiceps

A trial with 200 ewes and 127 lambs showed that vaccination of lambs with 2 doses of Oncosphere Secretory Antigen (OSA) 4 weeks apart, at either 4-8 and 8-12 weeks or at 12-16 and 16-20 weeks of age, was equally effective in protecting them against infestation with the larval stage of Taenia multiceps. In this trial, the lambs of ewes, vaccinated with OSA when they were 90 and again 120 days pregnant, were as susceptible to infestation as the lambs of untreated control ewes. Another trial to provoke passive immunity in lambs gave inconclusive results. In a 3rd trial 2 doses of regular OSA and 2 doses of freeze-dried OSA protected all the lambs in each group, while a single dose of regular OSA protected 9 out of 10 lambs against cerebral lesions.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.lmchunu2014mn201

Surgical transfer of the cysticerci of Taenia hydatigena

Unattached immature cysticerci of Taenia hydatigena were transferred surgically to the peritoneal cavities of 4 sheep. Mature infective cysticerci were recovered from the recipient sheep 3 and 5, 8 months later. A fully developed live cysticercus was present in the muscle layers surrounding the scar of the laparotomy site in 2 of the animals.The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

An attempt to treat the larval stage of Taenia multiceps and a résumé of its neural and extraneural distribution in sheep

Sheep were experimentally infested with the larval stage of Taenia multiceps. On Day 36 postinfestation 2 animals were treated intraperitoneally with mebendazole at 40 mg/kg body mass. Mature viable coenuri were present in the cerebra of both these animals when they were killed on Day 114. From Day 36-Day 49 3 animals were treated daily per os with mebendazole at 100 mg/ kg body mass. At autopsy 1 animal had a developing coenurus in the cerebrum while the other 2 animals were not infested. The drug thus had no effect on the development or viability of the coenuri by either of the 2 routes of administration. When a coenurus from a sheep treated intraperitoneally was fed to a cestode-free dog, 5 adult T. multiceps were recovered from the animal 21 days later. The larvae of this cestode undergo some development in extraneural tissues but rarely attain a size of more than 2 mm before they die and degenerate. The pathological changes in these degenerate lesions are briefly described.The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

Adenomatose Pulmonaire ovine: transmission experimental£ aux agneaux au moyen de cellules en culture et d'homogenats de cellules

Studies on the transmission of jaagsiekte (ovine pulmonary adenomatosis) both by sub inoculation of cells of known sex and by cell homogenates into male and female lambs are reported. The results obtained indicate a thymocyte-dependent rejection of male cells in female recipients in contrast to the successful transplantation of male cells in male animals and female cells in both sexes. This suggests the presence of a surface antigen determined by the Y-chromosome in the tumour cells. A second mechanism of transmission, dependent on the transformation of the recipient's cells, was demonstrated by 2 cases of heterologous transplantation and confirmed by inoculation of cellular homogenatesThe articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

Experimental transmission of jaagsiekte (ovine pulmonary adenomatosis) to goats

Jaagsiekte was successfully transmitted to at least 2 out of 6 goats inoculated intratracheally with partially purified jaagsiekte retrovirus. Multiple, small, well circumscribed nodules found in the lungs consisted of typical papilliform proliferations of neoplastic Type II epithelial cells. Histological evidence of a mild interstitial pneumonia in 4 of the experimental animals can probably be attibuted to a contaminating lentivirus in the jaagsiekte retrovirus preparation, as suggested by the seroconversion of the animals.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.lmchunu2014mn201

The pathology of chronic Drechslera campanulata toxicosis in inbred rats

Cultures on autoclaved maize of the phytopathogenic fungus, Drechslera campanulata, were incorporated into diets and fed to male inbred BDIX rats. In a pilot trial, a diet containing 30% D. campanulata culture material killed 5 out of 5 rats in 15-25 days. Lesions included gastric corpus erosions, gastrorrhagia and ulcerative typhlitis. Diets containing 5 % or 10 % culture material induced erosive to ulcerative typhlitis and oedema and hyperplasia of the ileocaecal lymph nodes in 40 out of 40 rats. Other changes included: mass loss; normocytic, hyperchromic anaemia; leukocytosis with neutrophilia; reductions in plasma proteins, creatinine, calcium and cholesterol; elevated serum enzymes; hepatosis, nephrosis and mycoplasma-like interstitial pneumoma. No lesions were present in control rats, and their profiles were normal. Ulcerative typhlitis induced by D. campanulata in rats resembles that seen in chronic piperonyl butoxide intoxication as well as that due to single treatments of indomethacid, although small intestinal ulcers are more frequent in the latter. Overgrowth of intestinal flora may be involved in ulcer pathogenesis. The pathology of drechsleratoxicosis in rats is compared to that in sheep and goats where necrotic lesions in the forestomach and, to a lesser extent, in the caecum are characteristic findings.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.lmchunu2014mn201