Preliminary study: Comparison of antioxidant activity of cannabidiol (CBD) and α-tocopherol added to refined olive and sunflower oils

This study evaluates the antioxidant activity of cannabidiol (CBD), added to model systems of refined olive (ROO) and sunflower (SO) oils, by measuring the peroxide value, oxidative stability index (OSI), electron spin resonance (ESR) forced oxidation, and DPPH• assays. Free acidity, a parameter of hydrolytic rancidity, was also examined. CBD was compared using the same analytical scheme with α-tocopherol. CBD, compared to α-tocopherol, showed a higher scavenging capacity, measured by DPPH• assay, but not better oxidative stability (OSI) of the oily systems considered. In particular, α-tocopherol (0.5%) showed an antioxidant activity only in SO, registered by an increase of more than 30% of the OSI (from 4.15 ± 0.07 to 6.28 ± 0.11 h). By ESR-forced oxidation assay, the concentration of free radicals (μM) in ROO decreased from 83.33 ± 4.56 to 11.23 ± 0.28 and in SO from 19.21 ± 1.39 to 6.90 ± 0.53 by adding 0.5% α-tocopherol. On the contrary, the addition of 0.5% CBD caused a worsening of the oxidative stability of ROO (from 23.58 ± 0.32 to 17.28 ± 0.18 h) and SO (from 4.93 ± 0.04 to 3.98 ± 0.04 h). Furthermore, 0.5% of CBD did not lower dramatically the concentration of free radicals (μM) as for α-tocopherol, which passed from 76.94 ± 9.04 to 72.25 ± 4.13 in ROO and from 17.91 ± 0.95 to 16.84 ± 0.25 in SO

A note on the optimality of decomposable entanglement witnesses and completely entangled subspaces

Entanglement witnesses (EWs) constitute one of the most important entanglement detectors in quantum systems. Nevertheless, their complete characterization, in particular with respect to the notion of optimality, is still missing, even in the decomposable case. Here we show that for any qubit-qunit decomposable EW (DEW) W the three statements are equivalent: (i) the set of product vectors obeying \bra{e,f}W\ket{e,f}=0 spans the corresponding Hilbert space, (ii) W is optimal, (iii) W=Q^{\Gamma} with Q denoting a positive operator supported on a completely entangled subspace (CES) and \Gamma standing for the partial transposition. While, implications $(i)\Rightarrow(ii)$ and $(ii)\Rightarrow(iii)$ are known, here we prove that (iii) implies (i). This is a consequence of a more general fact saying that product vectors orthogonal to any CES in C^{2}\otimes C^{n} span after partial conjugation the whole space. On the other hand, already in the case of C^{3}\otimes C^{3} Hilbert space, there exist DEWs for which (iii) does not imply (i). Consequently, either (i) does not imply (ii), or (ii) does not imply (iii), and the above transparent characterization obeyed by qubit-qunit DEWs, does not hold in general.Comment: 13 pages, proof of lemma 4 corrected, theorem 3 removed, some parts improve

Evaluation of Hemp Seed Oils Stability under Accelerated Storage Test

The interest in hemp seed oil has recently increased, due to the latest regulations which allow its use as food. Hemp seed oil is characterized by a high content of polyunsaturated fatty acids, which are highly prone to oxidation. Accelerated thermal oxidation (60 °C, 18 days) has been applied to nine types of cold-pressed hemp seed oils to monitor the evolution of the samples during oxidative deterioration. The results showed that the only determinations of primary (peroxide value) and secondary (TBARs) oxidation products did not allow a sufficient or correct evaluation of the oxidative changes of hemp seed oils during storage. In fact, samples at the end of the test were primarily characterized by a high presence of oxidation volatile compounds and a significant decrease of antioxidants. Several volatiles identified before the accelerated storage, such as the predominant α-pinene and β-pinene, gradually decreased during the accelerated storage period. On the other hand, aldehydes (hexanal, (E)-2-hexenal, heptanal, (E,E)-2,4-hexadienal, (E)-2-heptenal, (E,E)-2,4-heptadienal, (E,Z)-2,4-heptadienal, 2-octenal, nonanal, nonenal, 2,4-nonadienal, (E,E)-2,4-decadienal and 2,4-decadienal), ketones (1-octen-3-one, 3-octen-2-one, (E,E)-3,5-octadien-2-one and 3,5-octadien-2-one), acids (propionic acid, pentanoic acid, hexanoic acid and heptanoic acid) and 2pentyl-furan increased during the accelerated storage, as principal markers of oxidation

Linking Research to Development in Pastoral Communities of Northern Kenya: Recent Experiences and Key Findings in Participatory Research Approaches

Over 50% of Kenya\u27s land mass is arid. The mainstay of the local economies of these areas is nomadic pastoralism. Arable agriculture is limited to the few oases and mountain zones. Due to the harsh climate, there are few alternative livelihood options available to the local communities of mostly herders. Efforts to improve agricultural productivity have often been hampered by low adoption of available technologies. This low adoption is linked to many factors, notably the non-involvement of the stakeholders in the research process and the weak linkage between research and extension. To address these shortcomings, new approaches were tested with the aim of improving acceptability and use of agricultural technologies and knowledge in a pastoral community of northern Kenya

Management of chronic lymphocytic leukemia: practice guidelines from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation.

The Italian Society of Hematology (SIE) and two affiliate societies (SIES and GITMO) commissioned a project to develop clinical practice guidelines for the treatment of chronic lymphocytic leukemia (CLL). METHODS: Key questions in the management of patients with CLL were formulated by an Advisory Committee and approved by an Expert Panel of eight senior hematologists. After a systematic review of the literature, recommendations for disease-specific and supportive therapies were formulated and graded according to the supporting evidence. Explicit consensus methods were used for providing recommendations for questions with incomplete or potentially biased evidence. RESULTS: It is recommended that therapy is commenced in patients with CLL when at least one of the following are present: B-symptoms, progressive/obstructive lymphadenopathy or organomegaly, rapid lymphocyte doubling time, anemia or thrombocytopenia (of new onset, worsening or steroid-resistant). It is recommended that patients without co-morbidity should receive fludarabine plus cyclophosphamide, whereas elderly patients with co-morbidity should receive oral chlorambucil. Younger patients with unfavorable biological risk factors should be considered for high-dose chemotherapy and autologous or allogeneic stem cell transplantation within approved clinical trials. Patients either relapsing rapidly after, or non-responsive to, first-line chlorambucil should receive fludarabine-containing regimens. Patients either relapsing soon after or not responding to fludarabine-based chemotherapy should be considered for schedules including non-cross-reactive agents, such as alemtuzumab, possibly followed by high-dose chemotherapy and autologous transplantation in the context of a clinical trial or by allogeneic stem cell transplantation. CONCLUSIONS: We describe the results of a systematic literature review and an explicit approach to consensus techniques which resulted in recommendations for the key therapeutic decisions in patients with CLL

Canine placenta histological findings and microvascular density: The histological basis of a negative neonatal outcome?

Placenta is essential for the development of the fetus, and its impaired function can lead to a negative outcome (i.e., neonatal mortality). In dogs, investigations on placenta histology and neonatal outcome in healthy bitches are lacking, and a contribution is provided in this study to emphasize the use of placenta histology in practice. Fifty-one placentas from 11 litters were collected during cesarean section, classified according to the litter size (large (L) or small (S)) and the outcome, this latter as healthy (Group 1) or dead within 7 days (Group 2). The placenta/puppy weight ratio (PPR) was calculated, and specimens were formalin-fixed and paraffin-wax embedded, and on the resulting histological slides, capillary density (CD) was quantified. Among necrosis, calcification, and intravascular leucocytes, only the presence of multifocal-confluent necrosis (significantly more frequent in Group 2) was associated with a higher risk of death within 7 days (odds ratio = 30.7). Mixed logistic regression ruled out the effect on death both of a bitch and cesarean type (programmed vs. emergency). PPR and CD values were associated with litter size; large litters had lower PPR (p < 0.01) and higher CD (p < 0.05) than small litters. The relationship between PPR and CD was negative and significant (p < 0.01). Necrosis was a frequent finding in canine placentas, but only when multifocal-confluent was it associated with a poor outcome. The litter size influenced PPR (lower in L) and CD (higher in L), and this is likely due to the plasticity of placenta adaptation

Insulin Infusion During Normoglycemia Modulates Insulin Secretion According to Whole-Body Insulin Sensitivity

OBJECTIVE—Glucose is the major stimulus for insulin release. Time course and amount of insulin secreted after glycemic stimulus are different between type 2 diabetes mellitus (T2DM) patients and healthy subjects. In rodents, it was demonstrated that insulin can modulate its own release. Previous studies in humans yielded contrasting results: Insulin was shown to have an enhancing effect, no effect, or a suppressive effect on its own secretion. Thus, we aimed to evaluate short-term effects of human insulin infusion on insulin secretion during normoglycemia in healthy humans and T2DM subjects of both sex. RESEARCH DESIGN AND METHODS—Hyperinsulinemic-isoglycemic clamps with whole-body insulin-sensitivity (M) and C-peptide measurements for insulin secretion modeling were performed in 65 insulin-sensitive (IS) subjects (45 6 1 year, BMI: 24.8 6 0.5 kg/m2), 17 insulin-resistant (IR) subjects (466 2 years, 28.16 1.3 kg/m2), and 20 T2DMpatients (566 2 years, 28.0 6 0.8 kg/m2; HbA1c = 6.7 6 0.1%). RESULTS—IS subjects (M = 8.8 6 0.3 mg z min21 z kg21) had higher (P, 0.00001) whole-body insulin sensitivity than IR subjects (M = 4.0 6 0.2) and T2DM patients (M = 4.3 6 0.5). Insulin secretion profiles during clamp were different (P, 0.00001) among the groups, in

Cultivating Connection

Student leadership is an increasingly utilized tool on college campuses for welcoming and supporting new students as they transition to college. In our various experiences as previous student leaders turned student affairs professionals, we found a common thread in our work which made a tremendous difference in the development of student leaders and the students they served—the ability to create and maintain meaningful empathic connections. This paper will provide structure for orientation, transition, and retention (OTR) professionals to cultivate empathy in student leaders who may use those skills to build stronger and more authentic connections as they welcome and help students successfully navigate their transition to college. The purpose of this paper is to fill a gap in empathic leadership development and its potential to positively impact the transition and retention of new students