14 research outputs found
Secondary Metabolites of Marine Microbes: From Natural Products Chemistry to Chemical Ecology
Marine natural products (MNPs) exhibit a wide range of pharmaceutically relevant bioactivities, including antibiotic, antiviral, anticancer, or anti-inflammatory properties. Besides marine macroorganisms such as sponges, algae, or corals, specifically marine bacteria and fungi have shown to produce novel secondary metabolites (SMs) with unique and diverse chemical structures that may hold the key for the development of novel drugs or drug leads. Apart from highlighting their potential benefit to humankind, this review is focusing on the manifold functions of SMs in the marine ecosystem. For example, potent MNPs have the ability to exile predators and competing organisms, act as attractants for mating purposes, or serve as dye for the expulsion or attraction of other organisms. A large compilation of literature on the role of MNPs in marine ecology is available, and several reviews evaluated the function of MNPs for the aforementioned topics. Therefore, we focused the second part of this review on the importance of bioactive compounds from crustose coralline algae (CCA) and their role during coral settlement, a topic that has received less attention. It has been shown that certain SMs derived from CCA and their associated bacteria are able to induce attachment and/or metamorphosis of many benthic invertebrate larvae, including globally threatened reef-building scleractinian corals. This review provides an overview on bioactivities of MNPs from marine microbes and their potential use in medicine as well as on the latest findings of the chemical ecology and settlement process of scleractinian corals and other invertebrate larvae
Voltage stability in a long-distance power transmission system impacted by the geoelectric field due to a geomagnetic disturbance
Geoelectric hazard assessment: the differences of geoelectric responses during magnetic storms within common physiographic zones
Estimating ionospheric currents by inversion from ground-based geomagnetic data and calculating geoelectric fields for studies of geomagnetically induced currents
Successful Identification of Duck Genome Region Determining Desirable Uniformity of Meat Performance Traits
Assessing the hazard from geomagnetically induced currents to the entire high-voltage power network in Spain
The characteristics of geoelectric fields at Kakioka, Kanoya, and Memambetsu inferred from voltage measurements during 2000 to 2011
Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery
High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing
High-throughput fluorescence assays for ion channels and GPCRs
Ca2+, Na+ and K+- permeable ion channels as well as GPCRs linked to Ca2+ release are important drug targets. Accordingly, high-throughput fluorescence plate reader assays have contributed substantially to drug discovery efforts and pharmacological characterization of these receptors and ion channels. This chapter describes some of the basic properties of the fluorescent dyes facilitating these assay approaches as well as general methods for establishment and optimisation of fluorescence assays for ion channels and Gq-coupled GPCRs