16 research outputs found

    Pharmacological Strategies for the Management of Levodopa-Induced Dyskinesia in Patients with Parkinson’s Disease

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    Momentum transfer from the DART mission kinetic impact on asteroid dimorphos

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    The NASA Double Asteroid Redirection Test (DART) mission performed a kinetic impact on asteroid Dimorphos, the satellite of the binary asteroid (65803) Didymos, at 23:14 UTC on September 26, 2022 as a planetary defense test1. DART was the first hypervelocity impact experiment on an asteroid at size and velocity scales relevant to planetary defense, intended to validate kinetic impact as a means of asteroid deflection. Here we report the first determination of the momentum transferred to an asteroid by kinetic impact. Based on the change in the binary orbit period2, we find an instantaneous reduction in Dimorphos's along-track orbital velocity component of 2.70 ± 0.10 mm s-1, indicating enhanced momentum transfer due to recoil from ejecta streams produced by the impact3,4. For a Dimorphos bulk density range of 1,500 to 3,300 kg m-3, we find that the expected value of the momentum enhancement factor, [Formula: see text], ranges between 2.2 and 4.9, depending on the mass of Dimorphos. If Dimorphos and Didymos are assumed to have equal densities of 2,400 kg m-3, [Formula: see text]. These [Formula: see text] values indicate that significantly more momentum was transferred to Dimorphos from the escaping impact ejecta than was incident with DART. Therefore, the DART kinetic impact was highly effective in deflecting the asteroid Dimorphos

    Biosorption of Metals and Metalloids

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    Industrial activities such as mining operations, refining of ores and combustion of fuel oils play a relevant role in environmental pollution since their wastes contain high concentrations of toxic metals that can add significant contamination to natural water and other water sources if no decontamination is previously applied. As toxic metals and metalloids, including arsenic, cadmium, lead, mercury, thallium, vanadium, among others, are not biodegradable and tend to accumulate in living organisms, it is necessary to treat the contaminated industrial wastewaters prior to their discharge into the water bodies. There are different remediation techniques that have been developed to solve elemental pollution, but biosorption has arisen as a promising clean-up and low-cost biotechnology. Biosorption is one of the pillars of bioremediation and is governed by a variety of mechanisms, including chemical binding, ion exchange,physisorption, precipitation, and oxide-reduction. This involves operations(e.g. biosorbent reuse, immobilization, direct analysis of sample without destruction) that can be designed to minimize or avoid the use or generation of hazardous substances that have a negative impact on the environment and biota, thus following the concepts of "green chemistry" and promoting the environmental care. Furthermore, it has to be specially considered that the design of a biosorption process and the quality of a biosorbent are normally evaluated from the equilibrium, thermodynamic, and kinetic viewpoints.Therefore, a successful biosorption process can be only developed based on multidisciplinary knowledge that includes physical chemistry, biochemistryand technology, among other fields.In this chapter, we explain in detail all the aforementioned aspects. State of the art applications of biosorbents for metals and metalloids removal are carefully revised based on a complete analysis of the literature. Thus, it is evidenced in this chapter that the main points to consider regarding biosorption are the type of biomaterial (e.g. bacteria, fungi, algae, plant?derivatives and agricultural wastes, chitin/chitosan based materials) and the presence of a broad set of functional groups on their surface that are effective for the removal of different toxic metals and metalloids. In fact, removal percentages as high as 70-100% can be found in most works reported in the literature, which is demonstrating the excellent performance obtained with biosorbents. Also, biosorbents have evolved with the help of nanotechnology to modern bio-nano-hybrids materials having superlative sorption properties due to their high surface area coming from the nano-materials structures and multifunctional capacity incorporated from the several types of chemical groups of biomaterials. These, as well as other important aspects linked to biosorption are fully covered in the present chapter.Fil: Escudero, Leticia Belén. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Quintas, Pamela Yanina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Wuilloud, Rodolfo German. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Dotto, Guilherme L.. Universidade Federal de Santa Maria; Brasi

    Deciphering the cells of origin of squamous cell carcinomas

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    Squamous cell carcinomas (SCCs) are among the most prevalent human cancers. SCC comprises a wide range of tumours originated from diverse anatomical locations that share common genetic mutations and expression of squamous differentiation markers. SCCs arise from squamous and non-squamous epithelial tissues. Here, we discuss the different studies in which the cell of origin of SCCs has been uncovered by expressing oncogenes and/or deleting tumour suppressor genes in the different cell lineages that compose these epithelia. We present evidence showing that the squamous differentiation phenotype of the tumour depends on the type of mutated oncogene and the cell of origin, which dictate the competence of the cells to initiate SCC formation, as well as on the aggressiveness and invasive properties of these tumours.SCOPUS: re.jinfo:eu-repo/semantics/publishe
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