Serviceability performance of buildings founded on rubber–soil mixtures for geotechnical seismic isolation

Base isolation is a low-damage seismic design strategy that can be used for constructing resilient structures. Geotechnical seismic isolation (GSI) is a new category of emerging base isolation techniques that has attracted global interest in the past decade. Research on GSI based on rubber-soil mixtures (RSM) has focused on structural performance under earthquake actions, whilst there are concerns over the serviceability limit states (SLS) requirements in relation to (i) human comfort under strong winds and (ii) ground settlement under gravity, which may induce cracking and durability issues in structures. This article presents the first study on the serviceability performance of buildings constructed with the GSI-RSM system. The finite element model of a coupled soil-foundation-structure system has been validated by data recorded from geotechnical centrifuge testing. The numerical estimates of ground settlement have also been compared with analytical predictions. It is concluded that the GSI-RSM system can satisfactorily fulfill the SLS requirements

Geotechnical seismic isolation based on high-damping polyurethane:centrifuge modelling

Geotechnical seismic isolation (GSI) is a new category of low-damage resilient design methods that are in direct contact with geomaterials and of which the isolation mechanism primarily involves geotechnics. Various materials have been explored for placing around the foundation system in layer form to facilitate the beneficial effects of dynamic soil-foundation-structure interaction, as one of the GSI mechanisms. To reduce the thickness of the GSI foundation layer and to ensure uniformity of its material properties, the use of a thin and homogeneous layer of high-damping polyurethane (HDPU) was investigated in this study via centrifuge modelling. HDPU sheets were installed in three different configurations at the interface between the structural foundation and surrounding soils for realising GSI. It was found that using HDPU for GSI can provide excellent seismic isolation effects in all three configurations. The average rates of structural demand reduction amongst the eight earthquake events ranged from 35 to 80%. A clear correlation between the period-lengthening ratio and the demand reduction percentage can be observed amongst the three GSI configurations. One of the configurations with HDPU around the periphery of the foundation only is particularly suitable for retrofitting existing structures and does not require making changes to the structural systems or architectural features.</p

Crowdsourcing step-by-step information extraction to enhance existing how-to videos

Millions of learners today use how-to videos to master new skills in a variety of domains. But browsing such videos is often tedious and inefficient because video player interfaces are not optimized for the unique step-by-step structure of such videos. This research aims to improve the learning experience of existing how-to videos with step-by-step annotations. We first performed a formative study to verify that annotations are actually useful to learners. We created ToolScape, an interactive video player that displays step descriptions and intermediate result thumbnails in the video timeline. Learners in our study performed better and gained more self-efficacy using ToolScape versus a traditional video player. To add the needed step annotations to existing how-to videos at scale, we introduce a novel crowdsourcing workflow. It extracts step-by-step structure from an existing video, including step times, descriptions, and before and after images. We introduce the Find-Verify-Expand design pattern for temporal and visual annotation, which applies clustering, text processing, and visual analysis algorithms to merge crowd output. The workflow does not rely on domain-specific customization, works on top of existing videos, and recruits untrained crowd workers. We evaluated the workflow with Mechanical Turk, using 75 cooking, makeup, and Photoshop videos on YouTube. Results show that our workflow can extract steps with a quality comparable to that of trained annotators across all three domains with 77% precision and 81% recall

3D Reconstruction using Kinect Sensor and Parallel Processing on 3D Graphics Processing Unit

One of depth cameras such as the Microsoft Kinect is much cheaper than conventional 3D scanning devices, thus it can be acquired for everyday users easily. However, the depth data captured by Kinect over a certain distance is of low quality. In this work, we implement a set of algorithms allowing users to capture 3D surfaces by using the handheld Kinect. As a classic alignment algorithm such as the Iterative Closest Point (ICP) does not show efficacy in aligning point clouds that have limited overlapped regions, another coarse alignment using the Sample Consensus Initial Alignment (SAC-IA) is incorporated in to the registration process in order to ameliorate 3D point clouds’ fitness. Two robust reconstruction methods namely the Alpha Shapes and the Grid Projection are also implemented to reconstruct 3D surface from registered point clouds. The experimental results have shown the efficiency and applicability of of our blueprint. The constructed system obtains acceptable results in a few minutes with a low price device, thus it may practically be an useful approach for avatar generations or online shoppings

In vitro antioxidant activity and bioactive compounds from Calocybe indica

Nowadays, the use of mushrooms in medicine is ubiquitous and has achieved particular success. The antioxidants in mushrooms can deactivate free radicals. This study assesses the antioxidant potential of mushroom Calocybe indica with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging methods and the total antioxidant capacity. The mushroom’s ethanol extract exhibits acceptable activity with a low IC50 value (240.11 μg/mL), approximately 2.9 times lower than that of the mushroom Ophiocordyceps sobolifera extract. The ABTS scavenging rate of the extract is around 60% at 500 µg/mL, and the total antioxidant capacity is equivalent to 64.94 ± 1.03 mg of GA/g or 77.42 ± 0.42 μmol of AS/g.  The total phenolics, flavonoids, polysaccharides, and triterpenoids are equivalent to 29.33 ± 0.16 mg of GAE/g, 17.84 ± 0.11 mg of QUE/g (5.04 ± 0.04%), and 4.96 ± 0.04 mg of oleanolic acid/g, respectively. Specifically, the total triterpenoid content has been reported for the first time. The mushroom can have potential biomedical applications

Camellia sinensis extract delays microbiological and oxidative changes in striped catfish fillets during frozen storage

peer reviewedThis study investigated the effects of tea leaf (Camellia sinensis) extract on the quality of striped catfish (Pangasianodon hypophthalmus) fillets during 18-months of frozen storage (-20 ± 2 °C). Fillet samples were submitted to the treatments Control (cold tap water), CS 7.63 (C. sinensis extract solution 7.63 µg/mL) and CS 625 (C. sinensis extract 625 µg/mL) and stored for 18 months, with collections performed at 0, 1, 3, 6, 9, 12 and 18 months. Total viable count, physicochemical parameters (water holding capacity, total volatile basic nitrogen, peroxide value, thiobarbituric acid reactive substances, moisture and pH), sensory properties and color measurement were evaluated. Results showed that fillets treated with C.a sinensis extracts slightly reduced lipid oxidation, inhibited bacterial growth and improved sensory properties compared to untreated samples, without causing significant changes in the other quality indicators. The findings indicated that the green tea leaf extract immersion treatments, contributed to the improved quality preservation of striped catfish fillets during frozen storage

Building the hospital event-based surveillance system in Viet Nam: a qualitative study to identify potential facilitators and barriers for event reporting

Introduction: Hospitals are a key source of information for the early identification of emerging disease outbreaks and acute public health events for risk assessment, decision-making, and public health response. The objectives of this study were to identify potential facilitators and barriers for reporting of unusual events from the curative sector to the preventive medicine system in Viet Nam. Methods: In 2016, we conducted 18 semi-structured in-depth interviews and 9 focus group discussions with representatives from the curative and preventive medicine sectors in four provinces. We transcribed the interviews and focus group discussions and conducted a thematic analysis of the factors that appeared to affect public health event reporting. Results: We identified five major themes. Firstly, the lack of a legal framework to guide reporting meant there was an over-reliance on internal procedures. Secondly, participants reported the importance of an enabling environment to facilitate reporting such as leadership support and having focal points for reporting. Thirdly, potential benefits for reporting were seen such as support during outbreaks and receiving feedback. Fourthly, some challenges prohibited timely reporting such as not perceiving reporting to be the task of the curative sector and hesitancy to report without laboratory confirmation. Finally, the limited resources and specialist capacities in remote areas hindered timely detection and reporting of unusual events. Discussion: This study identified potential opportunities to promote the detection and reporting of unusual events from health care workers to the public health sector, and thus improving the overall health security system in Viet Nam and beyond

Combination Antifungal Therapy for Cryptococcal Meningitis

Background Combination antifungal therapy (amphotericin B deoxycholate and flucytosine) is the recommended treatment for cryptococcal meningitis but has not been shown to reduce mortality, as compared with amphotericin B alone. We performed a randomized, controlled trial to determine whether combining flucytosine or high-dose fluconazole with high-dose amphotericin B improved survival at 14 and 70 days. Methods We conducted a randomized, three-group, open-label trial of induction therapy for cryptococcal meningitis in patients with human immunodeficiency virus infection. All patients received amphotericin B at a dose of 1 mg per kilogram of body weight per day; patients in group 1 were treated for 4 weeks, and those in groups 2 and 3 for 2 weeks. Patients in group 2 concurrently received flucytosine at a dose of 100 mg per kilogram per day for 2 weeks, and those in group 3 concurrently received fluconazole at a dose of 400 mg twice daily for 2 weeks. Results A total of 299 patients were enrolled. Fewer deaths occurred by days 14 and 70 among patients receiving amphotericin B and flucytosine than among those receiving amphotericin B alone (15 vs. 25 deaths by day 14; hazard ratio, 0.57; 95% confidence interval [CI], 0.30 to 1.08; unadjusted P=0.08; and 30 vs. 44 deaths by day 70; hazard ratio, 0.61; 95% CI, 0.39 to 0.97; unadjusted P=0.04). Combination therapy with fluconazole had no significant effect on survival, as compared with monotherapy (hazard ratio for death by 14 days, 0.78; 95% CI, 0.44 to 1.41; P=0.42; hazard ratio for death by 70 days, 0.71; 95% CI, 0.45 to 1.11; P=0.13). Amphotericin B plus flucytosine was associated with significantly increased rates of yeast clearance from cerebrospinal fluid (−0.42 log10 colony-forming units [CFU] per milliliter per day vs. −0.31 and −0.32 log10 CFU per milliliter per day in groups 1 and 3, respectively; P<0.001 for both comparisons). Rates of adverse events were similar in all groups, although neutropenia was more frequent in patients receiving a combination therapy. Conclusions Amphotericin B plus flucytosine, as compared with amphotericin B alone, is associated with improved survival among patients with cryptococcal meningitis. A survival benefit of amphotericin B plus fluconazole was not found