19 research outputs found
Cyanobacterial lipopolysaccharides and human health – a review
Cyanobacterial lipopolysaccharide/s (LPS) are frequently cited in the cyanobacteria literature as toxins responsible for a variety of heath effects in humans, from skin rashes to gastrointestinal, respiratory and allergic reactions. The attribution of toxic properties to cyanobacterial LPS dates from the 1970s, when it was thought that lipid A, the toxic moiety of LPS, was structurally and functionally conserved across all Gram-negative bacteria. However, more recent research has shown that this is not the case, and lipid A structures are now known to be very different, expressing properties ranging from LPS agonists, through weak endotoxicity to LPS antagonists. Although cyanobacterial LPS is widely cited as a putative toxin, most of the small number of formal research reports describe cyanobacterial LPS as weakly toxic compared to LPS from the Enterobacteriaceae. We systematically reviewed the literature on cyanobacterial LPS, and also examined the much lager body of literature relating to heterotrophic bacterial LPS and the atypical lipid A structures of some photosynthetic bacteria. While the literature on the biological activity of heterotrophic bacterial LPS is overwhelmingly large and therefore difficult to review for the purposes of exclusion, we were unable to find a convincing body of evidence to suggest that heterotrophic bacterial LPS, in the absence of other virulence factors, is responsible for acute gastrointestinal, dermatological or allergic reactions via natural exposure routes in humans. There is a danger that initial speculation about cyanobacterial LPS may evolve into orthodoxy without basis in research findings. No cyanobacterial lipid A structures have been described and published to date, so a recommendation is made that cyanobacteriologists should not continue to attribute such a diverse range of clinical symptoms to cyanobacterial LPS without research confirmation
The use of cultured Acer cells as a screening tool for mitotic inhibitors. I. Reference herbicides
Recent Advances in High-Frequency Electron Spin Resonance Detection Using a Microcantilever
Atomistic study of electrostatics and carrier transport properties of CNT@MS2 (M = Mo, W) and CNT@BN core–shell nanotubes
Nonbonded Interatomic Potential Functions and Crystal Structure: Non Hydrogen-Bonded Organic Molecules
Novel Analogue of Colchicine Induces Selective Pro-Death Autophagy and Necrosis in Human Cancer Cells
Charophyceae (charales)
The charophytes, or stoneworts, are a group of green algae with six extant genera in one family, distributed worldwide in freshwater ponds and lakes. They are among the green algal groups most closely related to land plants and exhibit a complex thallus, with multinucleate internodal cells joined at nodes comprising smaller, uninucleate cells giving rise to whorled branchlets. Two genera (Chara, Nitella) contain most of the described species, with a third (Tolypella) containing several dozen taxa. The remaining genera have one or a few species. Reproduction is oogamous, with sperm and eggs produced in separate multicellular structures. The thallus is haploid; the zygote is the only diploid cell in the life cycle, and meiosis is followed by the development of a resistant spore. Thalli and spores are often encrusted with calcium carbonate. Such spores are abundant in the fossil record of the Charales, which extends to the Upper Silurian, and many genera and families have become extinct. These algae provide important ecosystem services, for example, as colonizing species, as biological agents for producing water clarity, or as the base of the food web. Charophytes are important for the study of evolution of embryophyte development, growth meristems, and cell biophysics. As one of the green algal groups most closely related to land plants, the rich charophyte fossil record may reveal clues regarding the earliest algae that invaded the land