7 research outputs found
Frequent co-occurrence of high-grade dysplasia in large flat colonic polyps (>20Â mm) and synchronous polyps
Prevalência de adenomas colorretais em pacientes com história familiar para câncer colorretal Prevalence of colorectal adenomas in patients with family history of colorectal cancer
O câncer colorretal (CCR) é uma doença comum e letal, influenciada por fatores genéticos e ambientais, e pela interação entre ambos. Seu risco está fortemente associado ao número e à idade dos parentes de primeiro grau com história de CCR. O objetivo foi estudar a prevalência de adenomas em pacientes com história familiar de câncer colorretal. Métodos: Realizou-se um estudo retrospectivo, tendo como alvo todos os pacientes submetidos à colonoscopia em um hospital de referência da cidade de Porto Alegre, entre 2003 e 2007. Resultados: Dos 2.462 pacientes estudados, 118 apresentaram história familiar para CCR e 2.344 não apresentaram. Nos dois grupos, houve predomÃnio do sexo feminino (P=0,001). Nos pacientes com adenomas e história familiar para CCR, houve predomÃnio do sexo feminino. Já nos pacientes com adenomas e sem história familiar, o sexo masculino foi mais frequente (P=0,032). O número de adenomas entre eles não foi estatisticamente significativo (P=0,187). Conclusão: O grupo com história familiar para CCR mostrou mais mulheres (P=0,001) e a idade também foi inferior (P=0,002). A comparação entre o grupo com adenomas e história familiar para CCR mostrou um número maior de mulheres que o grupo com adenomas sem história familiar para CCR (P=0,032).<br>Colorectal cancer is a common and lethal disease, influenced by genetic and environmental factors and the interaction between both. The risk of colorectal cancer is strongly associated with the number and age of first degree relatives with colorectal cancer. Methods: A retrospective study was performed having as its objective all the patients submitted to colonoscopy in a reference hospital in the city of Porto Alegre, between 2003 and 2007. The goal is to study the prevalence of adenomas in patients with family history of colorectal cancer. Results: From the 2,462 analyzed patients, 118 had family history for colorectal cancer and 2,344 did not have. In both groups there was predominance of females (P=0.001). In the patients with adenomas and family history of colorectal cancer, there was predominance of females. In the patients with no family history of colorectal cancer there was predominance of males (P=0.032). The number of adenomas between them was not statistically significant (P=0.187). Conclusion: The group with family history of colorectal cancer has shown more women (P=0.001) and the age was also lower (P=0.002). The comparison between the group with adenomas and family history for colorectal cancer has shown a bigger number of women than the group with adenomas with no family history for colorectal cancer (P=0.032)
microRNA-221 and microRNA-18a identification in stool as potential biomarkers for the non-invasive diagnosis of colorectal carcinoma
The Cost-Effectiveness of CT Colonography in Screening for Colorectal Neoplasia
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71544/1/j.1572-0241.2006.00970.x.pd