10 research outputs found
Periarticular Bone Changes in Osteoarthritis
Osteoarthritis (OA) can be considered an organ failure
with pathological aspects in cartilage, bone, ligaments,
and synovium. Altogether, these tissue changes can
result in pain and immobilizationâa failure of the joint.
It is well regarded that OA is a complex multifactorial
disease with many risk factors and different etiological
pathways that all lead to an apparently similar end
stage. Bony changes are clearly observed in advanced
OA. However, little understanding exists on the role of
these changes, whether they are a consequence of
cartilage damage or precede this damage and maybe
play an important role in the etiological process. Even
more important is the issue of pain. Radiological scores
of OA do not match well with pain and mobility scores,
which questions the value of these scoring systems. It
seems that we do not assess the most relevant
parameters. Evaluation of conventional and new radiographic
parameters is still an extensive part of the OA
research field. We may have overlooked certain (subtle)
parameters that can be extracted from x-rays, but other
imaging modalities such as MRI, CT, or SPECT might
better represent OA in a clinically relevant manner