24 research outputs found
The hnRNP family: insights into their role in health and disease
Get PDFHeterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies
Plasma AA and DHA levels are not compromised in newly diagnosed gestational diabetic women
No full textSusceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS
No full textDistinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions
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The Association of Methylenetetrahydrofolate Reductase Genotypes with the Risk of Childhood Leukemia in Taiwan
No full textInternational relations between war and revolution: Wilsonian diplomacy and the making of the Treaty of Versailles
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