2,750 research outputs found
Structural Geology of the Skitchewaug Mountain Area
Guidebook, forty-sixth annual conference, October 9-10, 1954: Trip
Drying air-induced disturbances in multi-layer coating systems
A range of new experimental techniques is developed to quantify drying-air induced disturbances on low viscosity
single and multi-layer coating systems. Experiments on prototype slide-bead coating systems show that the surface
disturbances take the form of a wavelike pattern and quantify precisely how its amplitude increases rapidly with wet
thickness and decreases with viscosity. Heat transfer measurements show that the redistribution of water to form an
additional lower viscosity carrier layer while increasing the solids concentration of the upper layer or layers enables
the maximum drying rate, for which drying-air induced surface disturbances are acceptably small, to be increased
with significant commercial benefits
Metabolic origins of spatial organization in the tumor microenvironment.
The genetic and phenotypic diversity of cells within tumors is a major obstacle for cancer treatment. Because of the stochastic nature of genetic alterations, this intratumoral heterogeneity is often viewed as chaotic. Here we show that the altered metabolism of cancer cells creates predictable gradients of extracellular metabolites that orchestrate the phenotypic diversity of cells in the tumor microenvironment. Combining experiments and mathematical modeling, we show that metabolites consumed and secreted within the tumor microenvironment induce tumor-associated macrophages (TAMs) to differentiate into distinct subpopulations according to local levels of ischemia and their position relative to the vasculature. TAMs integrate levels of hypoxia and lactate into progressive activation of MAPK signaling that induce predictable spatial patterns of gene expression, such as stripes of macrophages expressing arginase 1 (ARG1) and mannose receptor, C type 1 (MRC1). These phenotypic changes are functionally relevant as ischemic macrophages triggered tube-like morphogenesis in neighboring endothelial cells that could restore blood perfusion in nutrient-deprived regions where angiogenic resources are most needed. We propose that gradients of extracellular metabolites act as tumor morphogens that impose order within the microenvironment, much like signaling molecules convey positional information to organize embryonic tissues. Unearthing embryology-like processes in tumors may allow us to control organ-like tumor features such as tissue repair and revascularization and treat intratumoral heterogeneity
Baryon resonances from a novel fat-link fermion action
We present first results for masses of positive and negative parity excited
baryons in lattice QCD using an O(a^2) improved gluon action and a Fat Link
Irrelevant Clover (FLIC) fermion action in which only the irrelevant operators
are constructed with fat links. The results are in agreement with earlier
calculations of N^* resonances using improved actions and exhibit a clear mass
splitting between the nucleon and its chiral partner, even for the Wilson
fermion action. The results also indicate a splitting between the lowest J^P =
1/2^- states for the two standard nucleon interpolating fields.Comment: 5 pages, 3 figures, talk given by W.Melnitchouk at LHP 2001 workshop,
Cairns, Australi
Electromagnetic Form Factors with FLIC fermions
The Fat-Link Irrelevant Clover (FLIC) fermion action provides a new form of
nonperturbative O(a) improvement and allows efficient access to the light
quark-mass regime. FLIC fermions enable the construction of the
nonperturbatively O(a)-improved conserved vector current without the
difficulties associated with the fine tuning of the improvement coefficients.
The simulations are performed with an O(a^2) mean-field improved
plaquette-plus-rectangle gluon action on a 20^3 x 40 lattice with a lattice
spacing of 0.128 fm, enabling the first simulation of baryon form factors at
light quark masses on a large volume lattice.
Magnetic moments, electric charge radii and magnetic radii are extracted from
these form factors, and show interesting chiral nonanalytic behavior in the
light quark mass regime.Comment: Presented by J.Zanotti at the Workshop on Lattice Hadron Physics,
Cairns, Australia, 2003. 7pp, 8 figure
Light Quark Simulations With FLIC Fermions
Hadron masses are calculated in quenched lattice QCD in order to probe the
scaling behavior of a novel fat-link clover fermion action in which only the
irrelevant operators of the fermion action are constructed using APE-smeared
links. Light quark masses corresponding to an m_pi / m_rho ratio of 0.35 are
considered to assess the exceptional configuration problem of clover-fermion
actions. This Fat-Link Irrelevant Clover (FLIC) fermion action provides scaling
which is superior to mean-field improvement and offers advantages over
nonperturbative improvement, including reduced exceptional configurations.Comment: 3 pages, 2 figures, Lattice2002(QCD Spectrum and Quark Masses
Novel fat-link fermion actions
The hadron mass spectrum is calculated in lattice QCD using a novel fat-link
clover fermion action in which only the irrelevant operators of the fermion
action are constructed using smeared links. The simulations are performed on a
16^3 X 32 lattice with a lattice spacing of a=0.125 fm. We compare actions with
n=4 and 12 smearing sweeps with a smearing fraction of 0.7. The n=4 Fat Link
Irrelevant Clover (FLIC) action provides scaling which is superior to
mean-field improvement, and offers advantages over nonperturbative O(a)
improvement.Comment: 5 pages, 2 figures, talk given by J.Zanotti at LHP 2001 workshop,
Cairns, Australi
Elastic scattering and breakup of 17^F at 10 MeV/nucleon
Angular distributions of fluorine and oxygen produced from 170 MeV 17^F
incident on 208^Pb were measured. The elastic scattering data are in good
agreement with optical model calculations using a double-folding potential and
parameters similar to those obtained from 16^O+208^Pb. A large yield of oxygen
was observed near \theta_lab=36 deg. It is reproduced fairly well by a
calculation of the (17^F,16^O) breakup, which is dominated by one-proton
stripping reactions. The discrepancy between our previous coincidence
measurement and theoretical predictions was resolved by including core
absorption in the present calculation.Comment: 9 pages, 5 figure
The New ‘Hidden Abode’: Reflections on Value and Labour in the New Economy
In a pivotal section of Capital, volume 1, Marx (1976: 279) notes that, in order to understand the capitalist production of value, we must descend into the ‘hidden abode of production’: the site of the labour process conducted within an employment relationship. In this paper we argue that by remaining wedded to an analysis of labour that is confined to the employment relationship, Labour Process Theory (LPT) has missed a fundamental shift in the location of value production in contemporary capitalism. We examine this shift through the work of Autonomist Marxists like Hardt and Negri, Lazaratto and Arvidsson, who offer theoretical leverage to prize open a new ‘hidden abode’ outside employment, for example in the ‘production of organization’ and in consumption. Although they can open up this new ‘hidden abode’, without LPT's fine-grained analysis of control/resistance, indeterminacy and structured antagonism, these theorists risk succumbing to empirically naive claims about the ‘new economy’. Through developing an expanded conception of a ‘new hidden abode’ of production, the paper demarcates an analytical space in which both LPT and Autonomist Marxism can expand and develop their understanding of labour and value production in today's economy. </jats:p
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