COMPLEXATION OF LISINOPRIL DRUG WITH ALKALINE EARTH AND TRANSITION METAL IONS IN MIXED SOLVENT MEDIA

Objective: To investigate the stability constant of Lisinopril hydrochloride drug with alkaline earth metal ions Mg(II), Ca(II) and transition metal ions Fe(III), Cu(II) using potentiometric titration technique in 20%(v/v) ethanol-water mixture at 27 °C temperature and at an ionic strength of 0.1M NaClO4. Materials and Methods: The ligand Lisinopril hydrochloride is soluble in 20% (v/v) ethanol-water mixture. NaOH, NaClO4, HClO4 and metal salts were of AR grade. The solutions used in the pH metric titration were prepared in double distilled water. All the measurements were made at 27 0Cin 20%(V/V) ethanol-water mixture at constant ionic strength of 0.1M NaClO4. The pH measurement were made using a digital pH meter. Results: The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine proton ligand (pKa) and metal-ligand stability constant (logK) values. It is observed that alkaline earth metal & transition metal ion forms 1:1 and 1:2 complexes. The order of stability constants for these metal complexes was as: Fe3+ > Cu2+ > Mg2+ > Ca2+ Conclusion: The stability constants of trivalent Fe show maximum stability whereas divalent Ca shows minimum stability

Adsorption of copper metal ion from aqueous solution by using low cost materials

In this study the matki (Vigna aconitifolia) seed husk was tested for removal of Cu metal ion from solution. Batch adsorption techniques were administered to measure the adsorption characteristics of the matki seed husk for Cu (II) metal ion removal from aqueous solutions. The adsorption isotherms, thermodynamic parameters, kinetics, effect of pH were examined. The results show that the utmost adsorption capacity of matki seed husk was approximately 80.39 % Cu (II) at temperature 305 K and at the initial Cu (II) metal ion concentration of 100 mg/L and at 5.1 pH. Adsorption isotherm data might be well fitted by Frendlich isotherm equation. Thermodynamic studies confirmed that the method was spontaneous and endothermic. The adsorption amounts of Cu (II) metal ion tend to extend with the rise in of pH. The relatively low cost and high capability of the matki seed husk make it potentially attractive adsorbent for the removal of Cu (II) metal ions from waste wate

Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media

The stability constant of Efavirenz drug with alkaline earth metal ions Mg(II), Ca(II)  and transition metal ions Fe(III), Cu(II) were investigate using pH metric titration technique in 20%(v/v) ethanol-water mixture at 27 °C temperature and at an ionic strength of 0.1M NaClO4.{Metal to ligand ratio = 1:5 & 1:1}The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine proton ligand (pKa) and metal-ligand stability constants (log K) values. It is observed that alkaline earth metal & transition metal ion forms 1:1 and 1:2 complexes. The order of stability constants for these metal complexes was as:                                                        Fe3+ > Cu2+ > Mg2+ > Ca2+   

Phytopharmacognostic, Antibacterial Activity of Different Extract of Terminalia Arjuna Roxb Leaves

The wealth of India is stored in the broad natural flora which has been gifted to her.  Endowed with a variety of agro-climatic conditions, India is a virtual herbarium of the world. The importance of medicinal and aromatic plants has been emphasized from time to time.  It is accepted that the drug of natural origin shall play an important role in health care, particularly in the rural areas of India. India is having a high knowledge of phototherapy from Ayurveda, and still, hundreds of potent drugs are yet to be evaluated scientifically.  Keeping this in view, we reviewed one of the potential trees whose leaves and other parts also have a potent traditional application, but it has not been much studied.

Studies of Complexation of Transition Metal Ions With Benazepril Drug in Aqueous Media: Thermodynamic Aspect

Stability constant of Benazepril hydrochloride drug with transition metal ions Fe3+, Co2+, Ni2+, Cu2+, Zn2+ and Cd2+ using a pH metric titration technique in 20%(v/v) ethanol-water mixture at three different temperatures 300K, 310K & 320K at an ionic strength of 0.1M NaClO4 were studied. The Calvin-Bjerrum method as adopted by Irving-Rossotti has been employed to determine metal-ligand stability, constant logK values. The trend in the formation constants for transition metal ions follows the order: Fe3+ > Cu2+ > Cd2+> Co2+ > Zn2+ > Ni2+. The thermodynamic parameters, such as Gibb’s free energy change (ΔG), entropy change (ΔS), and enthalpy change (ΔH) associated with the complexation reactions, were calculated

Custom prosthetic reconstruction of proximal tibial giant cell tumor

Giant cell tumor (GCT) also called osteoclastoma of bone is the most common bone tumor encountered by an orthopedic surgeon. GCT generally occurs in skeletally mature individuals with peak incidence in the third decade of life. Less than 5% are found in patients with open physis and only about 10% of cases occur in patients older than 65 years. We present a case of proximal tibia GCT managed with custom mega prosthetic arthroplasty

Custom prosthetic reconstruction of distal femoral giant cell tumor

Giant cell tumor (GCT) also called osteoclastoma of bone is the most common bone tumor encountered by an orthopedic surgeon. GCT generally occurs in skeletally mature individuals with peak incidence in the third decade of life. Less than 5% are found in patients with open physis and only about 10% of cases occur in patients older than 65 years. We present a case of distal femoral GCT managed with custom mega prosthetic arthroplasty

Custom mega prosthetic reconstruction of juxta articular giant cell tumors

Introduction: Giant cell tumor (GCT) also called osteoclastoma of bone is the most common osteolytic bone tumor encountered by an orthopedic surgeon. En bloc resection of major joints creates a problem for the reconstruction of large defects. Recent advances in tumor resection defects involve the use of custom-built joints for the reconstruction of defects near joints. This article analyzes the functional outcomes after resection of juxta articular GCTs and reconstruction by custom mega prosthetic arthroplasty. Aims and Objectives: To study the functional results of custom mega prosthetic reconstruction in juxta articular GCTs with intra articular extension. Materials and Methods: Four patients with juxta articular GCTs around the hip and knee with mean age of 40 yrs (range 30 to 50 yrs) underwent resection and reconstruction by custom mega prosthetic arthroplasty during the period 2011 to 2013. Two patients were males and two were females. All of them were in Enneking stage 3. Proximal femur was involved in one patient, distal femur in one and proximal tibia in two patients. Results: Functional results were analyzed using Ennekings criteria. Excellent results were obtained in all the patients without recurrence, periprosthetic fractures, infections or aseptic loosening. Conclusion: By using the technique of custom mega prosthetic reconstruction in juxta articular GCTs with pathological fractures or intra articular extension, the desired goals of reconstruction with good functional results and least complications can be achieved