Testing strengths-based interventions: a preliminary study on the effectiveness of a program targeting curiosity, gratitude, hope, humor, and zest for enhancing life satisfaction

The study compares the impact of character strengths-based positive interventions in a sample of 178 adults. An experimental group that trained strengths of the Values-in-Action classification that typically correlate highly with life satisfaction (curiosity, gratitude, hope, humor, and zest) was compared in its gain in life satisfaction with a group that trained strengths that usually demonstrate low correlations with life satisfaction (appreciation of beauty and excellence, creativity, kindness, love of learning, and perspective) and a wait-list control group. If pre and post measures in life satisfaction were compared, the group with the strengths most correlated with life satisfaction improved significantly (statistically) in their satisfaction in comparison to a control group. This could be interpreted as support for the idea that primarily those strengths that correlate highly with life satisfaction should be addressed in strengths-based interventions. When asked for subjective ratings of well-being after the interventions concluded, participants in both intervention groups indicated gains above that of a wait-listed control group. Further analyses underscore the special role of self-regulation in facilitating success in the interventions. Overall, the data underline the potential of strength-based interventions for improving human well-being

Arthroscopy of the hip in children and adolescents

Intra-articular abnormalities of the hip, such as labral tears, loose bodies, chondral lesions, ligamentum teres tears and femoral acetabular impingement are increasingly being recognized in the pediatric age group. Evaluation for these abnormalities starts with a good history and physical exam. Radiographic imaging with plain films and magnetic resonance imaging help confirm the clinical impression. Arthroscopy of the hip can be utilized to diagnose and treat these abnormalities. Arthroscopy of the hip is a challenging procedure with a learning curve that requires a thorough knowledge of the anatomy of the hip. The hip is a deeply recessed joint that has a large muscular envelope, thick joint capsule and convex and concave surfaces of the femoral head and acetabulum, respectively. The normal anatomy may be distorted due to childhood developmental disorders such as hip dysplasia, Legg–Calve–Perthes Disease and Slipped Capital Femoral Epiphysis that adds additional challenges to the arthroscopist. Isolated intra-articular abnormalities occur rarely and an underlying morphologic abnormality should be identified which also requires management. Complications can be minimized with attention to detail

VEGF-A splicing: the key to anti-angiogenic therapeutics?

The physiology of microvessels limits the growth and development of tumours. Tumours gain nutrients and excrete waste through growth-associated microvessels. New anticancer therapies target this microvasculature by inhibiting vascular endothelial growth factor A (VEGF-A) splice isoforms that promote microvessel growth. However, certain VEGF-A splice isoforms in normal tissues inhibit growth of microvessels. Thus, it is the VEGF-A isoform balance, which is controlled by mRNA splicing, that orchestrates angiogenesis. Here, we highlight the functional differences between the pro-angiogenic and the anti-angiogenic VEGF-A isoform families and the potential to harness the synthetic capacity of cancer cells to produce factors that inhibit, rather than aid, cancer growth

The Association Between Spirituality/Religiosity and Well-Being in Young, Middle and Old Age in Switzerland

In contemporary literature, religiosity and spirituality are increasingly being recognized as important aspects of well-being. Spirituality and religiosity are multifaceted and highly interrelated constructs. In this chapter, we focus on two aspects: First, we explore the importance of religiosity and spirituality in the life of the participants of the Hope-Barometer 2015 by comparing groups of different demographic backgrounds (i.e., age groups, gender). Second, we investigate the associations between religiosity/spirituality on the one hand, and subjective and physical well-being on the other. Based on these results and further analyses, interesting insights into the role of religion and spirituality in the life of persons of different age stages can be gained. The chapter further discusses how religiosity and spirituality can play an important role in the context of critical life events and the adaptation to profound life transitions