Solvent and Temperature Effects on the Chiral Aggregation of Optically Active Poly(dialkylsilane)s Confined in Microcapsules

Terao K., Mori Y., Dobashi T., et al. Solvent and Temperature Effects on the Chiral Aggregation of Optically Active Poly(dialkylsilane)s Confined in Microcapsules. Langmuir, 20(2), 306-308, December 12, 2003. Copyright © 2003, American Chemical Society. https://doi.org/10.1021/la0302798

Circular Dichroism of Optically Active Poly(dialkylsilane) Aggregates in Microcapsules

Terao K., Kikuchi N., Sato S., et al. Circular Dichroism of Optically Active Poly(dialkylsilane) Aggregates in Microcapsules. Langmuir, 22(19), 7975-7980, August 10, 2006. Copyright © 2006, American Chemical Society. https://doi.org/10.1021/la060810+

Conformational transitions in poly{n-hexyl-[(S)-3-methylpentyl]silylene) in dilute solution: Temperature and molecular weight dependence detected by circular dichroism

Terao K., Terao Y., Teramoto A., et al. Conformational transitions in poly{n-hexyl-[(S)-3-methylpentyl]silylene) in dilute solution: Temperature and molecular weight dependence detected by circular dichroism. Macromolecules, 34(18), 6519-6525, July 24, 2001. Copyright © 2001, American Chemical Society. https://doi.org/10.1021/ma0104433

Temperature and solvent dependence of stiffness of poly{n-hexyl-[(s)-3-methylpentyl]silylene} in dilute solutions

Terao K., Terao Y., Teramoto A., et al. Temperature and solvent dependence of stiffness of poly{n-hexyl-[(s)-3-methylpentyl]silylene} in dilute solutions. Macromolecules, 34(13), 4519-4525, May 25, 2001. Copyright © 2001, American Chemical Society. https://doi.org/10.1021/ma010212w

Stiffness of polysilylenes depending remarkably on a subtle difference in chiral side chain structure: Poly{n-hexyl-[(S)-2-methylbutyl]silylene)} and poly{n-hexyl-[(S)-3-methylpentyl]silylene}

Terao K., Terao Y., Teramoto A., et al. Stiffness of polysilylenes depending remarkably on a subtle difference in chiral side chain structure: Poly{n-hexyl-[(S)-2-methylbutyl]silylene)} and poly{n-hexyl-[(S)-3-methylpentyl]silylene}. Macromolecules, 34(8), 2682-2685, March 16, 2001. Copyright © 2001, American Chemical Society. https://doi.org/10.1021/ma002030s

2D-Time of Flight MR Angiography in Intrathoracic Masses

正常ボランティア5例, 胸部腫瘤性病変の患者15例に対してMR Angiographyを施行した.MRAは, 6秒の息、止めでFLASH法(TR=20msec, TE=8msec, Flip angle=30°)を用いて撮像した像から作成した.全ての症例で胸部大動脈, 上大静脈, 下大静脈, 肺動脈及び肺静脈根部など太い血管の明瞭なMRA像が得られ, 腫瘤とそれら大血管系との関係が把握しやすく胸部腫瘤性病変の評価に有用と考えられた.MR Angiography of the thorax was performed in 5 healthy volunteers and 15 patients with intrathoracic masses. 2D-MRA was obtained sequentially by means of a fast low angle shot(FLASH)technique(TR=20msec.TE=8msec, Flip angle=30within a 6-second period of breath holding. MRA for great vessels was successfully completed in all volunteers and all patients. The relation between tumor and vasculature can be visualized so definitely that MRA may be thought to be a promising complement to MR imaging in the evaluation of intrathoracic masses

A case of trans-sternal bilateral thoracotomy for bilateral lung cancer.

Trans-sternal bilateral thoracotomy was performed to resect the right upper lobe and the left S1 + 2 + S3, and to complete lymphadenectomy in a 35-year-old female case of lung cancer in whom multiple lesions were suspected. Trans-sternal bilateral thoracotomy was considered to be useful for one-stage surgery in patients in whom bilateral lung cancer is suspected or confirmed, because it provides a sufficient surgical field enabling the resection of lung and lymph nodes. This may be the first case report of trans-sternal bilateral thoracotomy to treat multiple primary lung cancer.</p

Automated classification of pulmonary nodules through a retrospective analysis of conventional CT and two-phase PET images in patients undergoing biopsy

Objective(s): Positron emission tomography/computed tomography (PET/CT) examination is commonly used for the evaluation of pulmonary nodules since it provides both anatomical and functional information. However, given the dependence of this evaluation on physician’s subjective judgment, the results could be variable. The purpose of this study was to develop an automated scheme for the classification of pulmonary nodules using early and delayed phase PET/ CT and conventional CT images.Methods: We analysed 36 early and delayed phase PET/CT images in patients who underwent both PET/CT scan and lung biopsy, following bronchoscopy. In addition, conventional CT images at maximal inspiration were analysed. The images consisted of 18 malignant and 18 benign nodules. For the classification scheme, 25 types of shape and functional features were first calculated from the images. The random forest algorithm, which is a machine learning technique, was used for classification.Results: The evaluation of the characteristic features and classification accuracy was accomplished using collected images. There was a significant difference between the characteristic features of benign and malignant nodules with regard to standardised uptake value and texture. In terms of classification performance, 94.4% of the malignant nodules were identified correctly assuming that 72.2% of the benign nodules were diagnosed accurately. The accuracy rate of benign nodule detection by means of CT plus two-phase PET images was 44.4% and 11.1% higher than those obtained by CT images alone and CT plus early phase PET images, respectively.Conclusion: Based on the findings, the proposed method may be useful to improve the accuracy of malignancy analysis

RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients

RB1-inducible coiled-coil 1 (RB1CC1) plays a significant role in the enhancement of the retinoblastoma tumor suppressor (RB1) pathway and is involved in breast cancer development. However, RB1CC1's role in clinical progression of breast cancer has not yet been evaluated, so, as a first step, it is necessary to establish its usefulness as a tool to evaluate breast cancer patients. In this report, we have analyzed the correlation between abnormalities in the RB1CC1 pathway and long-term prognosis, because disease-specific death in later periods (>5 years) of the disease is a serious problem in breast cancer. Breast cancer tissues from a large cohort in Japan were evaluated by conventional immunohistochemical methods for the presence of the molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and other well-known prognostic markers for breast cancer, such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The correlation between the immunohistochemical results and clinical outcomes of 323 breast cancer patients was analyzed using a Kaplan-Meier log-rank test and a multivariate Cox proportional hazards regression analysis. Absence of nuclear RB1CC1 expression was associated with the worst prognosis (Log-rank test, Chi-Square value = 17.462, p<0.0001). Dysfunction of either one of RB1CC1, RB1, or p53 was associated with the highest risk for cancer-specific death, especially related to survival lasting more than 5 years (multivariate Cox proportional hazard ratio = 3.951, 95% Confidence Interval = 1.566–9.967, p = 0.0036). Our present data demonstrate that the combined evaluation of RB1CC1, RB1 and p53 by conventional immunohistochemical analysis provides an accurate prediction of the long-term prognoses of breast cancer patients, which can be carried out as a routine clinical examination