Are truncated stellar disks linked to the molecular gas density?

We know that the slope of the radial, stellar light distribution in galaxies is well described by an exponential decline and this distribution is often truncated at a break radius ($R_{br}$). We don't have a clear understanding for the origin of these outer truncations and several hypotheses have been proposed to explain them. We want to test the various theories with direct observations of the cold molecular gas for a few truncated galaxies in comparison with the non-truncated ones. The answer to the existence of a possible link between truncated stellar disks and the molecular gas density cannot be obtained from CO maps in the literature, because so far there are no galaxies with a clear truncation observed in CO at high resolution.Comment: 3 pages, 6 figures, to appear in Astrophysics and Space Science (Apss), special issue of "Science with ALMA: a new era for Astrophysics" conference, ed. Dr. Bachille

Studio e realizzazione di una infrastruttura di autenticazione e autorizzazione (AAI) italiana per servizi di biblioteca digitale

Obiettivo di questa Tesi di Laurea ? lo studio e la realizzazione di una Infrastruttura di Autenticazione e Autorizzazione Italiana per servizi di biblioteca digitale, proponendo il caso di studio del servizio NILDE. Nel primo capitolo si introducono i concetti principali legati alla gestione dell\u27identit` a digitale, si fornisce una classificazione dei sistemi e si evidenziano alcuni aspetti interessanti legati alle federazioni d\u27identit?. Il secondo capitolo presenta alcuni standard e tecnologie di rilievo per lo scambio di informazioni riguardo l\u27identit? digitale dei soggetti e per la gestione dell\u27autenticazione in maniera centralizzata. Viene inoltre introdotta una possibile soluzione tecnica per AAI. Il terzo capitolo presenta una panoramica dei servizi di biblioteca digitale attraverso una classificazione di questi servizi, diversi esempi e alcuni casi d\u27uso riguardanti la gestione dell\u27identit?. Nel quarto capitolo viene formulata la proposta di una AAI italiana per servizi di biblioteca digitale, basata su SAML/Shibboleth. Nel quinto capitolo vengono presentate le tappe che hanno portato alla realizzazione della AAI, attraverso seminari organizzati in collaborazione con il Consortium GARR, e il caso d\u27uso del sistema di gestione dell\u27identit? della Biblioteca dell\u27Area di Ricerca CNR di Bologna e del servizio NILDE

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The immunoprevention measures (vaccination by schedule plus mass campaigns) to achieve the objectives subscribed by PAHO/WHO produced around the year 2000 a sharp drop in cases of rubella and measles in Argentina. For this reason, there is currently a young population that only has immunity through the vaccine. Objective: Given the latent risk of reintroduction of these viruses in the country, we set out to investigate the presence of anti-rubella and anti-measles IgG antibodies in people aged 7 to 19 years who, according to the National Immunization Calendar and data from the National Surveillance Program, they should have two doses of triple viral vaccine and should not have had contact with the virus naturally. A retrospective, descriptive cross-sectional study was conducted. 180 samples from people between 7 and 19 years of age who attended the Fundación para el Progreso de la Medicina de Córdoba (FPM) for routine biochemical analyzes between the months of September 2021 and February 2022 were processed. rubella was determined by CMIA (ABBOTT) (FPM) while indirect immunofluorescence was performed for measles IgG at the Reina Fabiola University Clinic. The seroprevalences found were 88.3% and 92.2% for measles and rubella, respectively. There were no significant differences between antibody concentrations by age subgroup (rubella p=0.1435, measles p=0.1049), but the antibody concentration among women was significantly higher than among men (rubella p=0.036, measles p=0.031). Among women, anti-rubella IgG was higher in the younger age subgroup (p=0.0196), but not for measles (p=0.1874) nor among age subgroups of men (rubella p=0.7445, measles p=0.1236). The seroprevalences detected reach the coverage objective recommended by the WHO to prevent the circulation of rubella, but not the measles virus. These results show the need to sustain efforts to keep the prevalence of antibodies generated by vaccination high, also knowing that during the pandemic their application decreased, increasing the risk of virus reintroduction into the country.Las medidas de inmunoprevención (vacunación por calendario más campañas masivas) para lograr los objetivos suscriptos de la OPS/OMS produjeron hacia el año 2000 una caída abrupta de casos de rubéola y sarampión en Argentina. Por este motivo, actualmente existe una población joven que sólo tiene inmunidad a través de la vacuna. Objetivo: ante el riesgo latente de reintroducción de estos virus en el país, nos propusimos investigar la presencia de anticuerpos IgG anti-rubéola y antisarampión en personas de 7 a 19 años de edad que, de acuerdo al Calendario Nacional de Inmunizaciones y los datos del Programa Nacional de Vigilancia, deberían tener dos dosis de vacuna triple viral y no deberían haber tenido contacto con el virus de manera natural. Se realizó un estudio retrospectivo, descriptivo transversal. Se procesaron 180 muestras de personas de entre 7 y 19 años de edad que concurrieron a realizarse análisis bioquímicos de rutina a la Fundación para el Progreso de la Medicina de Córdoba (FPM) entre los meses de septiembre de 2021 y febrero de 2022. La IgG rubéola se determinó por CMIA (ABBOTT) (FPM) mientras que para IgG sarampión se realizó inmunofluorescencia indirecta en la Clínica Universitaria Reina Fabiola. Las seroprevalencias encontradas fueron del 88.3% y 92.2% para sarampión y rubéola respectivamente. No hubo diferencias significativas entre concentraciones de anticuerpos por subgrupo etario (rubéola p=0.1435, sarampión p=0.1049), pero la concentración de anticuerpos entre mujeres fue significativamente mayor que entre hombres (rubéola p=0.036, sarampión p=0.031). Entre mujeres la IgG anti-rubéola fue mayor en el subgrupo etario de menor edad (p=0.0196), no así para sarampión (p=0.1874) ni entre subgrupos etarios de hombres (rubéola p=0.7445, sarampión p=0.1236). Las seroprevalencias detectadas alcanzan el objetivo de cobertura recomendado por la OMS para impedir la circulación de rubéola, no así de virus sarampión. Estos resultados evidencian la necesidad de sostener los esfuerzos para mantener elevadas las prevalencias de anticuerpos generados por la vacunación, sabiendo además que durante la pandemia bajó la aplicación de las mismas, aumentando el riesgo de reintroducción de los virus en el país.

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Parvovirus B19/B19V primary infection in pregnant women can be transmitted to the embryo/fetus and cause anomalies associated with TORCH syndrome. Local knowledge of the infection can help visualize the clinical picture to achieve early diagnosis. The objectives were to identify B19V in suspected cases of parvoviral infection during pregnancy and to describe the clinical manifestations present in positive cases. Descriptive, cross-sectional study. Inclusion criteria: pregnant patients with suspected B19V infection (compatible maternal or fetal-neonatal clinical manifestations or with epidemiological link), newborns (NB) of mothers with suspected or confirmed infection and NB with signs/symptoms associated with congenital infection (still present or not at birth), selected according to medical records of the clinical history. Viral DNA (PCR), specific IgM and IgG (ELISA) were determined in serum samples stored at the institution’s biobank. Ethical Committee of participating centers approved the protocol: Clinica Universitaria Reina Fabiola, Hospital Universitario de Maternidad y Neonatología, Clínica Privada Vélez Sársfield (2018-2022). A total of 242 patients were included (epidemiological weeks/EW 1-52, 171 pregnant women and 71 NB, 60 of them were mother-NB pair). Infection was confirmed in 27/242 (11.1%) cases, the majority (24/27, 88.9%) in pregnant women and 3/27 (11.1%) in NB. In the mother-NB pair group, 9 pregnant women and 2 NB were positive (vertical transmission rate: 22.2%). Epidemiological characteristics of B19V+ cases: mean age of pregnant women 30.1±6.3 years (p=0.45 versus study sample; median 30.5), 96% in EW 15-52 (autumn-spring). Clinical manifestations in pregnant women: maternal anemia 14/24 (58.3%), hydrops fetalis 5/24 (20.8%), abortion 5/24 (20.8%), fetal anemia 2/24 (8.3%), polyhydramnios 1/24 (4.2%), rash and arthralgia 1/24 (4.2%). One NB presented hydrops, another anemia, and one was asymptomatic, born to mother with rash, arthralgia, and anemia). Laboratory markers of infection: 16/27 (59.3%) cases were confirmed by detection of viral DNA (DNA+/IgM-/IgG+). During the study period, B19V was detected in 11% of the sample, being frequent in symptomatic pregnant women (24/171, 14%), with a rate of transmission to the fetus of 22%. Upon clinical suspicion, the complementary determination of virus and antibodies can improve diagnostic performance.La primoinfección por parvovirus B19/B19V en la embarazada puede transmitirse al embrión/feto y causar manifestaciones clínicas asociadas al síndrome de TORCH. Conocer la infección en nuestro medio puede contribuir a visibilizar su presentación clínica y promover el diagnóstico temprano. Los objetivos fueron identificar B19V en casos sospechosos de infección parvoviral durante la gestación y describir las manifestaciones clínicas presentes en los casos positivos. Estudio descriptivo, transversal. Se incluyeron pacientes embarazadas con sospecha de infección por B19V (manifestaciones clínicas maternas o feto-neonatales compatibles o nexo epidemiológico), RN de madres con infección sospechada o confirmada y RN con signos/síntomas asociables a infección congénita (aún presentes o no al nacer), seleccionados a partir de los datos de la historia clínica. Se determinó ADN viral (PCR), IgM e IgG específicas (ELISA) en muestras de suero recuperadas del biobanco. Protocolo aprobado por los Comités de Ética de los centros participantes: Clínica Universitaria Reina Fabiola, Hospital Universitario de Maternidad y Neonatología, Clínica Privada Vélez Sársfield (2018-2022). Se estudiaron 242 pacientes (semanas epidemiológicas/SE 1-52, 171 embarazadas y 71 RN, de ellos 60 constituían binomio madre-RN), confirmándose la infección en 27/242 (11,1%), la mayoría (24/27, 88,9%) en embarazadas y 3/27 (11,1%) en RN. En el grupo de binomios, fueron positivos 9 embarazadas y 2 RN (tasa de transmisión vertical: 22,2%). Características epidemiológicas de los casos B19V+: edad promedio de las embarazadas 30,1±6,3 años (p=0,45 versus muestra estudiada; mediana 30,5), 96% en las SE 15-52 (otoño-primavera). Manifestaciones marcadoras en embarazadas: anemia materna 14/24 (58,3%), hydrops fetal 5/24 (20,8%), aborto 5/24 (20,8%), anemia fetal 2/24 (8,3%), polihidramnios 1/24 (4,2%), exantema y artralgia 1/24 (4,2%). Un RN presentó hydrops, otro anemia y otro fue asintomático (con antecedente de madre positiva con exantema, artralgia y anemia en la madre). Marcadores laboratoriales de infección: 16/27 (59,3%) casos fueron confirmados por detección de ADN viral (ADN+/IgM-/IgG+). En el período estudiado se detectó B19V en 11% de la muestra, siendo frecuente en embarazadas sintomáticas (24/171, 14%), con una tasa de transmisión al feto de 22%. Ante la sospecha clínica, la determinación complementaria de virus y anticuerpos puede mejorar el rendimiento diagnóstico.

APHRODITE: Design and Preliminary Tests of an Autonomous and Reusable Photo-sensing Device for Immunological Test aboard the International Space Station

Preliminary results of the design and manufacturing of APHRODITE, a compact and versatile device for carrying out analyses of biological fluids during space missions that will be used as a technological demonstrator on board the International Space Station (ISS) for the quantitative determination of salivary biomarkers indicators of alterations of functionality of the immune system. The paper addresses the design of the main subsystems of the analytical device and the preliminary results obtained during the first implementations of the device subsystems and testing measurements. In particular, the system design and the experiment data output of the lab-on-chip photosensors and of the front-end readout electronics are reported in detail

The PROVENT-C19 registry: A study protocol for international multicenter SIAARTI registry on the use of prone positioning in mechanically ventilated patients with COVID-19 ARDS

Background The worldwide use of prone position (PP) for invasively ventilated patients with COVID-19 is progressively increasing from the first pandemic wave in everyday clinical practice. Among the suggested treatments for the management of ARDS patients, PP was recommended in the Surviving Sepsis Campaign COVID-19 guidelines as an adjuvant therapy for improving ventilation. In patients with severe classical ARDS, some authors reported that early application of prolonged PP sessions significantly decreases 28-day and 90-day mortality. Methods and analysis Since January 2021, the COVID19 Veneto ICU Network research group has developed and implemented nationally and internationally the "PROVENT-C19 Registry", endorsed by the Italian Society of Anesthesia Analgesia Resuscitation and Intensive Care. . .'(SIAARTI). The PROVENT-C19 Registry wishes to describe 1. The real clinical practice on the use of PP in COVID-19 patients during the pandemic at a National and International level; and 2. Potential baseline and clinical characteristics that identify subpopulations of invasively ventilated patients with COVID-19 that may improve daily from PP therapy. This web-based registry will provide relevant information on how the database research tools may improve our daily clinical practice. Conclusions This multicenter, prospective registry is the first to identify and characterize the role of PP on clinical outcome in COVID-19 patients. In recent years, data emerging from large registries have been increasingly used to provide real-world evidence on the effectiveness, quality, and safety of a clinical intervention. Indeed observation-based registries could be effective tools aimed at identifying specific clusters of patients within a large study population with widely heterogeneous clinical characteristics. Copyright

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

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