The impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors

Objective: The development of bioinformatics and comprehensive genomic profiling (CGP) has provided insights into the ap-plicability and functionality of the genomic alterations (GA). In this study, we evaluated the impact of CGP on the treatment plan and outcomes in a significant number of patients. Material and Methods: We carried out a retrospective case-control study on 164 adult patients with advanced solid tumors from 15 oncology centers in Türkiye. Results: In all cases, CGP was performed within 23.8 [standard deviation (SD)±32.1] months of initial diagnosis. Non-small cell lung carcinoma, breast cancer, unknown primary carcinoma, colorectal carcinoma, and sarcoma were among the most common tumor types, accounting for 61.5% of all cases. CGP was performed immediately after the diagnosis of advanced cancer in 13 patients (7.9%). In 158 patients (96.4%), at least one GA was found as per the CGP report. Also, in the reports, the average tumor mutational burden (TMB) and GAs were 7.3 (SD±8.7) mut/Mb and 3.5 (SD±2.0), respectively. According to CGP reports, 58 patients had 79 evidence-based drug suggestions for their particular tumor type, whereas 97 patients had 153 evidence-based drug suggestions for another tumor type. After the primary oncologist interpreted the CGP reports, significant changes were made to the treatment of 35 (21.3%) patients. Conclusion: We strongly believe that in the future, high-TMB or other tumor-agnostic biomarkers will become much more afford-able, and CGP will serve as one of the major decision-making tools for the treatment of patients along with pathological, radiological or lab-oratory tests

Strain-elastografija kao koristan alat u procjeni neoplazmi mliječne žlijezde kuja

The aim of this study was to evaluate the diagnostic performance of strain elastography in the assessment of mammary neoplasms. Twenty-three dogs and a total number of 57 mammary neoplasms were included in this study. The elasticity score and strain ratio were measured using elastography recordings for comparison of histopathology results in mammary neoplasms. The mean elasticity scores were 1.66±0.15 for the benign neoplasms and 3.33±0.16 for the malignant tumors (P0.05). There was no significant difference found in distinguishing malignant mixed tumors and malignant epithelial tumors (P>0.05). The results of this study showed that, strain elastography is a highly valuable tool in differential diagnosis of mammary neoplasms in bitches.Cilj je rada bio prosuditi dijagnostičku učinkovitost strain-elastografije u procjeni neoplazmi mliječne žlijezde. Istraživanjem su obuhvaćena 23 psa i ukupno 57 neoplazmi mliječne žlijezde. Na elastografskim zapisima izmjereni su faktor čvrstoće (engl. elasticity score) i omjer čvrstoće (engl. strain ratio) radi usporedbe histopatoloških nalaza kod neoplazmi mliječne žlijezde. Prosječna vrijednost faktora čvrstoće bila je 1,66±0,15 za dobroćudne neoplazme i 3,33±0,16 za zloćudne tumore (P0,05) razlike među tim dvjema metodama u analizi zloćudnih epitelnih tumora u različitim stadijima, a statistički znakovite (P>0,05) razlike nije bilo ni između zloćudnih mješovitih tumora i zloćudnih epitelnih tumora. Rezultati ovog istraživanja pokazali su da je strain-elastografija izvrstan alat u diferencijalnoj dijagnostici neoplazmi mliječne žlijezde kuja