114 research outputs found

    VARIATION OF DEGUMMING RESISTANCE OF SERICIN CAUSED BY HEAT AND METALLIC SALT

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    ArticleJournal of the Faculty of Textiles and Sericulture, Shinshu University. Ser. B, Textile engineering 4: 1-16(1960)departmental bulletin pape

    Calcineurin knockout mice show a selective loss of small spines

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    Calcineurin is required for long-term depression and activity-dependent spine shrinkage, and calcineurin mutations have been identified in patients with schizophrenia. Moreover, mice with conditional knockout of calcineurin B (CNB-KO) exhibit behavioral abnormalities suggestive of schizophrenia. Changes in the dendritic spines of these mice, however, have not been investigated. We therefore examined the dendritic spines of CNB-KO mice, and observed a significant reduction in small spines and an increase in large spines in the prefrontal and visual cortices. The effect of CNB-KO on the spine sizes was relatively moderate, possibly due to the presence of spontaneous fluctuations (dynamics) in the dendritic spines themselves. Thus, CNB-KO mice showed a spine phenotype similar to those recently reported in patients with schizophrenia

    Labelling and optical erasure of synaptic memory traces in the motor cortex

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    Dendritic spines are the major loci of synaptic plasticity and are considered as possible structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of spines in the cortex has been unattainable, and thus, the link between spines and memory has been correlational. We developed a novel synaptic optoprobe, AS-PaRac1 (activated synapse targeting photoactivatable Rac1), which can label recently potentiated spines specifically, and induce the selective shrinkage of AS-PaRac1-containing spines. In vivo imaging of AS-PaRac1 revealed that a motor learning induced substantial synaptic remodelling in a small subset of neurons. The acquired motor learning was disrupted by the optical shrinkage of the potentiated spines, whereas it was not affected by the identical manipulation of spines evoked by a distinct motor task in the same cortical region. Taken together, our results demonstrate that a newly acquired motor skill depends on the formation of a task-specific dense synaptic ensemble

    Filarial nematodes belonging to the superorders Diplotriaenoidea and Aproctoidea from wild and captive birds in Japan

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    Eight species of filarial nematodes of the superorders Diplotriaenoidea and Aproctoidea were collected from the lung, air sac, abdominal cavity, and subdermal layer of the neck of wild and captive birds in Japan. The species of the filarial nematodes were identified as Diplotriaena bargusinica, D. henryi, Serratospiculum kwangsiensis, S. tendo, Hamatospiculum accipitris, H. cylindricum, H. quadridens, and Lissonema noctuae based on morphometry and pathogenicity. D. henryi from Poecile varius, H. accipitris from Accipiter gentilis, H. cylindricum from Lanius bucephalus and H. quadridens from Otus flammeolus represent the first host records worldwide. Moreover, D. henryi, S. kwangsiensis, H. cylindricum, and L. noctuae were the first geographical records from Japan

    Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

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    PREPARATION OF RAW INGREDIENTS: JAPAN\u27S EDUCATION OF INFORMATION SYSTEMS STUDENTS FOR CORPORATE COOKING

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    The MIS discipline in an American sense is not formed in Japan. It is meaningless to propose a Japanese information systems curriculum based on the MIS discipline. Under lifetime employment, Japanese companies have molded their own unique culture. The information systems adopted by a company must be attuned to its cultural line. The university education for people who will work at information systems in companies must be the raw education which will enable them to develop the skills appropriate to their company after training within the company; that is, corporate cooking. The authors propose a model curriculum specially designed to fit with these Japanese conditions
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