Encouraging Dialogue around Social Issues with Latinx Students Through Literature Discussion and Culturally Relevant Literature

This teacher research study examines literature discussions with fourth and fifth grade Latinx students about books that reflect Latinx experiences. For this study, the following questions are explored (1) What social issues do students discuss in literature groups? (2) How do literary response strategies influence student dialogue? And (3) How does my theoretical frame influence my decision making as a teacher? Theories that informed the construction of the literature discussions and the decision making occurring throughout the study are examined closely. The theories intertwine and bridge education and students’ experiences as a resource in learning more about the educational setting. In this study, the discussions of students and the literature response strategies are explored as the data is analyzed to examine the student discussions around issues of immigration, family separation, borders, and so much more. The findings in this study indicate that the experiences of Latinx students are integral to the educational setting and an education that invites who they are enhances their learning experiences. Latinx students are eager for learning opportunities that invite their voices and stories. It is through the construction and assessment of the educational setting that educators can promote culturally responsive, relevant, and sustaining teaching experiences that go beyond the classroom setting. Latinx students build relationships with each other and their teachers as they engage in discussions that allow them to share and learn with each other. This study is a reminder of the crucial role teachers play in creating such powerful spaces and the value that Latinx students bring into the classroom when invited to discuss, engage, and create powerful learning experiences

Evaluation of protective effect of cyclodextrin glucanotransferase-treated Gastrodia elata Blume extract on ultraviolet B-induced premature skin aging

Purpose: To investigate the protective effect of Gastrodia elata Blume (G. elata, GE) and cyclodextrin glucanotransferase (CGTase) enzyme-treated G. elata extract (EGE) against premature skin aging using ultraviolet B (UVB)-exposed normal human dermal fibroblasts (NHDFs).Methods: The extract was characterized by liquid chromatography with tandem mass spectrometry (LC-MS/MS), ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC–QToF–MS) and nuclear magnetic resonance spectroscopy (NMR). The expression of matrix  metalloproteinases (MMP-1,3), interleukin-6 (IL-6), transforming growth factor (TGF-β1) and procollagen type I was assayed using ELISA kits. Safety evaluation of EGE’s dietary administration and topical application was performed by in vivo acute oral toxicity and local lymph node tests.Results: Lower MMP-1 and IL-6 and higher procollagen type I and TGF-β1 levels were observed after treatment with EGE than with GE, indicating that EGE was more effective than GE in treating UVBinduced photoaging. With respect to phenolic composition, EGE had lower 4-hydroxybenzaldehyde (4- HBA) level and higher α-gastrodin level than GE. In UVB-irradiated NHDFs, α-gastrodin exhibited higher anti-aging activity than 4-HBA and β-gastrodin based on the expression of MMP-1, MMP-3, and procollagen type I. The in vivo data indicate that EGE was safe at concentrations of up to 2000 mg/kg for dietary administration and 0.1 % for topical application.Conclusion: EGE protects UVB-induced photoaged human skin better than GE owing to its higher α- gastrodin content. Thus, EGE may be potentially useful agent in anti-aging cosmetic products.Keywords: Gastrodia elata, α-Gastrodin, Anti-aging, CGTase, Ultraviolet B (UVB) irradiation, Matrix metalloproteinase, Procollagen, Normal human dermal fibroblast

Environmental impact assessment of the pangasius sector in the Mekong Delta

In the past seven years the export of white pangasius fillets grew fast. The culture method shifted to intensive production of striped catfish (Ca Tra) in deep ponds because this is more efficient than the pen and cage culture of Ca Basa. Today, striped catfish comprises more than 90 % of the culture. The increased production was achieved by producers investing in large ponds. The market chain is gearing towards vertical integration. Most farms keep fish at relatively high densities of 15 to 25 fish/m3 in ponds having a depth of up to 4m, and are advised to exchange daily 20 to 40% of the water. The sustainability of the sector is threatened due to the increased environmental pressure, and hampered by the growing cost of inputs and reduced farm-gate prices of the fish. The Environmental Impact Assessment (EIA) intends to identify measures for preventing or mitigating the environmental impacts of catfish culture in the Mekong Delta. The EIA was a seven-step process during which we interacted twice with part of the main stakeholders. To build trust among the stakeholders from the sector, we conducted the scoping and goal setting with them

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania

The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios and by direct typing of candidate loci in an additional 15,000 samples. We identify five replicable associations with genome-wide levels of evidence including a newly implicated variant on chromosome 6. Jointly, these variants account for around one-tenth of the heritability of severe malaria, which we estimate as -23% using genome-wide genotypes. We interrogate available functional data and discover an erythroid-specific transcription start site underlying the known association in ATP2B4, but are unable to identify a likely causal mechanism at the chromosome 6 locus. Previously reported HLA associations do not replicate in these samples. This large dataset will provide a foundation for further research on thegenetic determinants of malaria resistance in diverse populations.Peer reviewe

Determination of low level nitrate/nitrite contamination using SERS-active Ag/ITO substrates coupled to a self-designed Raman spectroscopy system

A portable and simple Raman scattering and photoluminescence spectroscopy system was set up for sensitive and rapid determination of nitrate/nitrite at low concentrations in water samples. The SERS (Surface Enhanced Raman Scattering) – active Ag/ITO substrates were prepared and employed to obtain the enhanced Raman scattering light from the sample. Concentrations as low as 1 ppm and 0.1 ppm were detectable for nitrate and nitrite, respectively. The obtained results confirmed the usefulness of the designed system in actual environmental measurements and analysis