PHYTOTHERAPY TREATMENT OF URINARY TRACT INFECTION IN CHILDREN

Urinal system infection is one of the most frequent bacterial infection diseases in childhood. approximately 30% of children suffer from relapses of urinal infections. Optimal therapy is very important to avoid the risk of kidney cicatrisation because of urinal infection. Last years specialists pay more attention to phyto medications, since they have both a complex action and a significantly fewer side effects as compared to synthetic medications. We have studied the action of Kanefrom phytomedication upon the urinal infection processes of children. We have found a reduced frequency of relapses among children with acute pyelonephritis, who were treated with the above medication for 3 months after a course of antibiotics. Children whose therapy was terminated after a course of antibiotics. Key words: pyelonephritis, urinal infection, prophylaxis, children, phytotherapy

PHYTOTHERAPY TREATMENT OF URINARY TRACT INFECTION IN CHILDREN

Urinal system infection is one of the most frequent bacterial infection diseases in childhood. approximately 30% of children suffer from relapses of urinal infections. Optimal therapy is very important to avoid the risk of kidney cicatrisation because of urinal infection. Last years specialists pay more attention to phyto medications, since they have both a complex action and a significantly fewer side effects as compared to synthetic medications. We have studied the action of Kanefrom phytomedication upon the urinal infection processes of children. We have found a reduced frequency of relapses among children with acute pyelonephritis, who were treated with the above medication for 3 months after a course of antibiotics. Children whose therapy was terminated after a course of antibiotics. Key words: pyelonephritis, urinal infection, prophylaxis, children, phytotherapy

ФИТОТЕРАПИЯ В ЛЕЧЕНИИ ИНФЕКЦИИ МОЧЕВОЙ СИСТЕМЫ У ДЕТЕЙ

Urinal system infection is one of the most frequent bacterial infection diseases in childhood. approximately 30% of children suffer from relapses of urinal infections. Optimal therapy is very important to avoid the risk of kidney cicatrisation because of urinal infection. Last years specialists pay more attention to phyto medications, since they have both a complex action and a significantly fewer side effects as compared to synthetic medications. We have studied the action of Kanefrom phytomedication upon the urinal infection processes of children. We have found a reduced frequency of relapses among children with acute pyelonephritis, who were treated with the above medication for 3 months after a course of antibiotics. Children whose therapy was terminated after a course of antibiotics. Key words: pyelonephritis, urinal infection, prophylaxis, children, phytotherapy.Инфекция мочевой системы — одно из наиболее частых бактериальных инфекционных заболеваний в детском возрасте. Приблизительно у 30% детей инфекция мочевыводящих путей рецидивирует. Из-за риска рубцевания почек при инфекции мочевыводящих путей очень важна оптимальная терапия. В последние годы все больше внимания уделяют фитопрепаратам, так как помимо комплексности их воздействия, у них значительно меньше побочных эффектов, по сравнению с синтетическими препаратами. Мы изучили действие растительного препарата Канефрон на течение инфекции мочевой системы у детей. Выявлено снижение частоты рецидивов у детей с острым пиелонефритом, получавших указанный препарат в течение 3 мес после окончания лечения антибиотиками по сравнению с детьми, у которых после курса антибиотиков терапия была прекращена.Ключевые слова: пиелонефрит, инфекция мочевых путей, профилактика, дети, фитотерапия. (Педиатрическая фармакология. – 2007;4(5):38-40

EFFICACY OF THE IMMUNOSUPPRESSIVE THERAPY AGAINST THE NEPHROTIC SYNDROME AMONG CHILDREN

The researchers evaluated the efficacy of different immunosuppressive medications in case of steroid dependent and steroid resistant variants of the nephrtic syndrome among children: traditional alkylating agents (cyclophosphamide, chlorbutin), cyclosporine and mycophenolate mofetil. Cyclosporine proved to be most efficient in treatment against steroid dependent nephritic syndrome, as the researchers were more often able to cancel the steroids, while the recurrence of the nephritic syndrome developed less often. In the event of the steroid resistant nephritic syndrome, the full/partial remission was achieved among more than 80% patients also treated by cyclosporine. In case of the proliferating forms of the steroid resistant nephritic syndrome, the positive outcome was achieved among all the children under observation, if mycophenolate mofetil and steroids were further applied. Therapy by the conventional alkylating agents (cyclophosphamide, chlorbutin) proved to be less efficient both for the relief from the steroid dependence and persistent remission of the steroid resistant nephritic syndrome.Key words: nephritic syndrome, immunosuppressive therapy, alkylating agents, cyclosporine, mycophenolate mofetil, children

Mitochondrial functions on oocytes and preimplantation embryos*

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization (IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays a vital role in the oocyte cytoplasm, for it can provide adenosine triphosphate (ATP) for fertilization and preimplantation embryo development and also act as stores of intracellular calcium and proapoptotic factors. During the oocyte maturation, mitochondria are characterized by distinct changes of their distribution pattern from being homogeneous to heterogeneous, which is correlated with the cumulus apoptosis. Oocyte quality decreases with the increasing maternal age. Recent studies have shown that low quality oocytes have some age-related dysfunctions, which include the decrease in mitochondrial membrane potential, increase of mitochondrial DNA (mtDNA) damages, chromosomal aneuploidies, the incidence of apoptosis, and changes in mitochondrial gene expression. All these dysfunctions may cause a high level of developmental retardation and arrest of preimplantation embryos. It has been suggested that these mitochondrial changes may arise from excessive reactive oxygen species (ROS) that is closely associated with the oxidative energy production or calcium overload, which may trigger permeability transition pore opening and subsequent apoptosis. Therefore, mitochondria can be seen as signs for oocyte quality evaluation, and it is possible that the oocyte quality can be improved by enhancing the physical function of mitochondria. Here we reviewed recent advances in mitochondrial functions on oocytes