Flow routing in mangrove forests: field data obtained in Trang, Thailand

Mangroves grow in the intertidal parts of sheltered tropical coastlines, facilitating coastal stabilization and wave attenuation. Mangroves are widely threatened nowadays, although past studies have indicated their contribution to coastal safety. Most of these studies were based on numerical modeling however and a proper database with field observations is lacking yet. This paper presents part of the results of an extensive field campaign in a mangrove area in Trang Province, Thailand. The study area covers the outer border of an estuarine mangrove creek catchment. Data have been collected on elevation, vegetation, water levels, flow directions and flow velocities throughout this study area. Due to the tough conditions in the field, developing a suitable method for data collection and processing has been a major challenge in this study. Analysis of the hydrodynamic data uncovers the change of flow directions and velocities throughout a mangrove creek catchment over one tidal cycle. In the initial stages of flooding and the final stages of ebbing, creeks supply water to the lower elevated parts of the mangroves. In between these stages, the entire forest bordering the estuary is flooded and flow directions are perpendicular to the forest fringe. Flow velocities within the creeks are still substantially higher than those within the forest, as the creeks also supply water to the back mangroves. These insights in flow routing are promising for the future analysis of sediment input and distribution in mangroves

Building the case for insulin-like growth factor receptor-I involvement in thyroid-associated ophthalmopathy

The pathogenesis of orbital Graves' disease (GD), a process known as thyroid-associated ophthalmopathy (TAO), remains incompletely understood. The thyrotropin receptor (TSHR) represents the central autoantigen involved in GD and has been proposed as the thyroid antigen shared with the orbit that could explain the infiltration of immune cells into tissues surrounding the eye. Another cell surface protein, insulin-like growth factor-I receptor (IGF-IR), has recently been proposed as a second antigen that participates in TAO by virtue of its interactions with anti-IGF-IR antibodies generated in GD, its apparent physical and functional complex formation with TSHR, and its necessary involvement in TSHR post-receptor signaling. The proposal that IGF-IR is involved in TAO has provoked substantial debate. Furthermore, several studies from different laboratory groups, each using different experimental models, have yielded conflicting results. In this article, we attempt to summarize the biological characteristics of IGF-IR and TSHR. We also review the evidence supporting and refuting the postulate that IGF-IR is a self-antigen in GD and that it plays a potentially important role in TAO. The putative involvement of IGF-IR in disease pathogenesis carries substantial clinical implications. Specifically, blocking this receptor with monoclonal antibodies can dramatically attenuate the induction by TSH and pathogenic antibodies generated in GD of proinflammatory genes in cultured orbital fibroblasts and fibrocytes. These cell types appear critical to the development of TAO. These observations have led to the conduct of a now-completed multicenter therapeutic trial of a fully human monoclonal anti-IGF-IR blocking antibody in moderate to severe, active TAO

Lessons Learned from Targeting IGF-I Receptor in Thyroid-Associated Ophthalmopathy

Complex immunological mechanisms underlie the pathogenesis of thyroid-associated ophthalmopathy (TAO). Historical models of Graves’ diseas

Ion channeling for strain analysis in buried nanofilms (

The title should have been: \"Ion channeling for strain anal. in buried nanofilms

Thyroid function and deiodinase activities in rats with marginal iodine deficiency

The hypothesis tested was whether marginal iodine deficiency for a period of 6 wk affects iodothyronine deiodinase activities in liver and brain of rats. Male rats were fed purified diets either deficient or sufficient in iodine; the diets were fed on a restricted basis (60% of ad libitum intake). Body weight gain of the two groups was comparable. Iodine deficiency was evidenced by increased thyroid weight (26%), reduced urinary iodine excretion (80%), and reduced plasma T4 concentrations (22%). Activities of liver type I and brain type III deiodinase were unchanged, but the activity of type II deiodinase in brain was increased (28%) in the iodine-deficient rats. Food restriction per se significantly lowered T3 (30%) and T4 (22%) concentrations in plasma and decreased type III deiodinase activity in brain (30%). These results indicate that in marginal iodine deficiency the activities of hepatic type I deiodinase and brain type III deiodinase are unchanged, whereas that of brain type II deiodinase is increased

Local scale invariance as dynamical space-time symmetry in phase-ordering kinetics

The scaling of the spatio-temporal response of coarsening systems is studied through simulations of the 2D and 3D Ising model with Glauber dynamics. The scaling functions agree with the prediction of local scale invariance, extending dynamical scaling to a space-time dynamical symmetry.Comment: Latex, 4 pages, 4 figure

Random Walks in Logarithmic and Power-Law Potentials, Nonuniversal Persistence, and Vortex Dynamics in the Two-Dimensional XY Model

The Langevin equation for a particle (`random walker') moving in d-dimensional space under an attractive central force, and driven by a Gaussian white noise, is considered for the case of a power-law force, F(r) = - Ar^{-sigma}. The `persistence probability', P_0(t), that the particle has not visited the origin up to time t, is calculated. For sigma > 1, the force is asymptotically irrelevant (with respect to the noise), and the asymptotics of P_0(t) are those of a free random walker. For sigma < 1, the noise is (dangerously) irrelevant and the asymptotics of P_0(t) can be extracted from a weak noise limit within a path-integral formalism. For the case sigma=1, corresponding to a logarithmic potential, the noise is exactly marginal. In this case, P_0(t) decays as a power-law, P_0(t) \sim t^{-theta}, with an exponent theta that depends continuously on the ratio of the strength of the potential to the strength of the noise. This case, with d=2, is relevant to the annihilation dynamics of a vortex-antivortex pair in the two-dimensional XY model. Although the noise is multiplicative in the latter case, the relevant Langevin equation can be transformed to the standard form discussed in the first part of the paper. The mean annihilation time for a pair initially separated by r is given by t(r) \sim r^2 ln(r/a) where a is a microscopic cut-off (the vortex core size). Implications for the nonequilibrium critical dynamics of the system are discussed and compared to numerical simulation results.Comment: 10 pages, 1 figur