On exact solutions for quantum particles with spin S= 0, 1/2, 1 and de Sitter event horizon

Exact wave solutions for particles with spin 0, 1/2 and 1 in the static coordinates of the de Sitter space-time model are examined in detail. Firstly, for a scalar particle, two pairs of linearly independent solutions are specified explicitly: running and standing waves. A known algorithm for calculation of the reflection coefficient $R_{\epsilon j}$ on the background of the de Sitter space-time model is analyzed. It is shown that the determination of R_{\epsilon j} requires an additional constrain on quantum numbers \epsilon \rho / \hbar c >> j, where \rho is a curvature radius. When taken into account of this condition, the R_{\epsilon j} vanishes identically. It is claimed that the calculation of the reflection coefficient R_{\epsilon j} is not required at all because there is no barrier in an effective potential curve on the background of the de Sitter space-time. The same conclusion holds for arbitrary particles with higher spins, it is demonstrated explicitly with the help of exact solutions for electromagnetic and Dirac fields.Comment: 30 pages. This paper is an updated and more comprehensive version of the old paper V.M. Red'kov. On Particle penetrating through de Sitter horizon. Minsk (1991) 22 pages Deposited in VINITI 30.09.91, 3842 - B9

Black Holes at the LHC

In these two lectures, we will address the topic of the creation of small black holes during particle collisions in a ground-based accelerator, such as LHC, in the context of a higher-dimensional theory. We will cover the main assumptions, criteria and estimates for their creation, and we will discuss their properties after their formation. The most important observable effect associated with their creation is likely to be the emission of Hawking radiation during their evaporation process. After presenting the mathematical formalism for its study, we will review the current results for the emission of particles both on the brane and in the bulk. We will finish with a discussion of the methodology that will be used to study these spectra, and the observable signatures that will help us identify the black-hole events.Comment: 37 pages, 14 figures, lectures presented in the 4th Aegean Summer School on Black Holes, 17-22 September 2007, Lesvos, Greece, typos corrected, comments and references adde

MYB regulates the DNA damage response and components of the homology-directed repair pathway in human estrogen receptor-positive breast cancer cells

Over 70% of human breast cancers are estrogen receptor-positive (ER+), most of which express MYB. In these and other cell types, the MYB transcription factor regulates the expression of many genes involved in cell proliferation, differentiation, tumorigenesis, and apoptosis. So far, no clear link has been established between MYB and the DNA damage response in breast cancer. Here, we found that silencing MYB in the ER+ breast cancer cell line MCF-7 led to increased DNA damage accumulation, as marked by increased γ-H2AX foci following induction of double-stranded breaks. We further found that this was likely mediated by decreased homologous recombination-mediated repair (HRR), since silencing MYB impaired the formation of RAD51 foci in response to DNA damage. Moreover, cells depleted for MYB exhibited reduced expression of several key genes involved in HRR including BRCA1, PALB2, and TOPBP1. Taken together, these data imply that MYB and its targets play an important role in the response of ER+ breast cancer cells to DNA damage, and suggest that induction of DNA damage along with inhibition of MYB activity could offer therapeutic benefits for ER+ breast cancer and possibly other cancer types.Ren-Ming Yang, Devathri Nanayakkara, Murugan Kalimutho, Partha Mitra, Kum Kum Khanna, Eloise Dray, Thomas J. Gond