Template Synthesis and Micellization of Block Copolymers with Interacting Blocks

It is known that А-В and А-В-А block copolymers with interacting blocks are related to the class of in-tramolecular polycomplexes. Such block copolymers form a stable micellar structures in dilute aqueous so-lutions due to hydrophobic interactions between non-polar bound segments of the blocks. Given micellar structures have attracted a considerable attention due to their possible applications as different templates, drug delivery systems, nanoreactors. Here we presented peculiarities of a template synthesis of the block copolymers consisting interacting poly(ethylene oxide) and poly(acrylic acid) blocks and also its self-assembly to micelles in acidic aqueous solutions, which was confirmed by Transmission Electron Microsco-py (TEM). When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3560

Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions

Encapsulaton of poorly soluble crystallizing drug prednisolone (PS) in micellar solutions of PAAm-b- PEO-b-PAAm triblock copolymer (TBC) based on chemically complementary poly(ethylene oxide) and polyacrylamide (MnPEO = 6 kDa, MnPAAm = 116 kDa) was studied by dynamic light scattering and transmission electron microscopy. The equilibrium mechanism of the encapsulation process and the effect of specific aggregation of PS-loaded micelles by their “coronas” that promoted the drug crystallization were established. The question about the presence of TBC micelles inside crystalline space was discussed. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3523

Micelles of Amphiphilic Diblock and Triblock Copolymers Based on Poly(ethylene oxide) and Poly(e-caprolactone) and Their Potential as Nanocontainers for Drugs

The amphiphilic MOPEO-b-PCL copolymers with biocompatible and biodegradable blocks in selective solvent form micelles of spherical and uncommon ellipsoidal morphology, which size and stability increase with the lengthening of “core”-forming hydrophobic PCL block. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3480

Block Copolymers Containing Poly(acrylic acid) for Stabilization of Vitamin E and Silver Nanoparticles in Aqueous Solutions

We have synthesized asymmetric di- and triblock copolymers containing chemically complementary blocks of poly(acrylic acid) and methoxypoly(ethylene oxide) (PAAc-b-MOPEO) or poly(ethylene oxide) (PAAc-b-PEO-b-PAAc) using a template radical block copolymerization process. At low pH, polyacid blocks of these copolymers were protonated and formed the intramolecular polycomplexes (IntraPCs) with MOPEO or PEO blocks. Due to both the intramolecular complex formation and hydrophobic interactions between non-polar bound segments of the blocks, an intensive micellization in copolymer solutions at low pH took place. Aqueous copolymer solutions were used as nanocontainers for encapsulation of poorly soluble vitamin E and as nanoreactors for the silver nanoclusters/nanoparticles formation. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3494

Morphology of Silver Nanoparticles in the Graft Copolymer Matrices

In the present work, we used two-component graft copolymers PVA-g-PААm based on poly(vinyl alcohol) and chemically complementary polyacrylamide as special templates in the process of borohydride reduction of Ag+ ions. It was established the influence of molecular architecture and concentration of the matrices and the content of silver nitrate on some reaction parameters, size, stability and morphology of Ag-nanoparticles in aqueous solutions. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3522

Anionic Micelle-Forming Triblock Copolymers as Nanocontainers for Doxorubicin

The anionic derivative of asymmetric triblock copolymer containing biocompatible chemically complementary polyacrylamide and poly(ethylene oxide) (PAAm-b-PEO-b-PAAm) was obtained. The micellization of the initial (TBC) and modified (TBC-COOH) copolymer samples in aqueous solution were investigated. Practically the same values of the critical micellization concentration and the Gibbs free micellization energy for both TBCs were found. The anticancer effects of the doxorubicin (DOX)-loaded micelles of the initial and modified triblock copolymers were studied on the tumor cells of human T-leukemia of Jurkat line, transformed leukemia of L929 line and mouse lymphatic leukemia of L1210 line. The fact of high efficacy of DOX/TBC and DOX/TBC-COOH compositions in compare with pure DOX was determined and discussed. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3497