Dynamical Generation of CKM Mixings by Broken Horizontal Gauge Interactions

The fermion mass matrices are calculated in the framework of the dynamical mass generation by the broken horizontal gauge interactions. The non-proportional mass spectra between up- and down-sectors and CKM mixings are obtained solely by radiative corrections due to the ordinary gauge interactions.Comment: 20 pages + 1 uuencoded eps figure, PHYZZ

Nonrigid chiral soliton for the octet and decuplet baryons

Systematic treatment of the collective rotation of the nonrigid chiral soliton is developed in the SU(3) chiral quark soliton model and applied to the octet and decuplet baryons. The strangeness degrees of freedom are treated by a simplified bound-state approach which omits the locality of the kaon wave function. Then, the flavor rotation is divided into the isospin rotation and the emission and absorption of the kaon. The kaon Hamiltonian is diagonalized by the Hartree approximation. The soliton changes the shape according to the strangeness. The baryons appear as the rotational bands of the combined system of the soliton and the kaon.Comment: 11 pages(LaTex), 1 figures(eps

A quantum isomonodromy equation and its application to N=2 SU(N) gauge theories

We give an explicit differential equation which is expected to determine the instanton partition function in the presence of the full surface operator in N=2 SU(N) gauge theory. The differential equation arises as a quantization of a certain Hamiltonian system of isomonodromy type discovered by Fuji, Suzuki and Tsuda.Comment: 15 pages, v2: typos corrected and references added, v3: discussion, appendix and references adde

Five-dimensional AGT Conjecture and the Deformed Virasoro Algebra

We study an analog of the AGT relation in five dimensions. We conjecture that the instanton partition function of 5D N=1 pure SU(2) gauge theory coincides with the inner product of the Gaiotto-like state in the deformed Virasoro algebra. In four dimensional case, a relation between the Gaiotto construction and the theory of Braverman and Etingof is also discussed.Comment: 12 pages, reference added, minor corrections (typos, notation changes, etc

Instability of the hedgehog shape for the octet baryon in the chiral quark soliton model

In this paper the stability of the hedgehog shape of the chiral soliton is studied for the octet baryon with the SU(3) chiral quark soliton model. The strangeness degrees of freedom are treated by a simplified bound-state approach, which omits the locality of the kaon wave function. The mean field approximation for the flavor rotation is applied to the model. The classical soliton changes shape according to the strangeness. The baryon appears as a rotational band of the combined system of the deformed soliton and the kaon.Comment: 24 pages, LaTeX, 8 eps file

Clinical efficacy of tocilizumab in patients with active rheumatoid arthritis in real clinical practice

The previous clinical studies have demonstrated tocilizumab monotherapy to be highly effective in rheumatoid arthritis (RA). The objectives of the present article are to report the efficacy and safety of tocilizumab in patients with active RA in real clinical practice. In total, 61 patients with RA were treated with tocilizumab. Any comorbidities they had, especially infections, were treated thoroughly before they were given the drug. We provided guidance on infection control and prevention. Mean age of the patients was 60.9 ± 12.4 years, and their mean disease duration 10.9 ± 9.2 years. The patients remained on steroids, methotrexate, and tacrolimus as before, but were taken off any other drugs they had been using prior to the treatment. Mean of the 28-joint disease activity score using erythrocyte sedimentation rate was 4.75 ± 1.15 initially and fell to 2.21 ± 0.97 after two doses (n = 50). After four doses, the remission rate was 83.8% (31/37). All patients responded well to the therapy and there was no decrease in the efficacy of tocilizumab during the treatment. Even in the real clinical setting, treatment with tocilizumab can rapidly induce remission in RA in a high proportion of patients and is generally safe and well tolerated. Tocilizumab would seem to be promising as a first-line choice for the treatment of RA